Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Anthony G, Coyne"'
Autor:
Vanessa M. Howieson, Joy Zeng, Joachim Kloehn, Christina Spry, Chiara Marchetti, Matteo Lunghi, Emmanuel Varesio, Andrew Soper, Anthony G. Coyne, Chris Abell, Giel G. van Dooren, Kevin J. Saliba
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 22, Iss , Pp 1-8 (2023)
Toxoplasma gondii is a pervasive apicomplexan parasite that can cause severe disease and death in immunocompromised individuals and the developing foetus. The treatment of toxoplasmosis often leads to serious side effects and novel drugs and drug tar
Externí odkaz:
https://doaj.org/article/00b024bbf99f4341a185721a0ef4505e
Autor:
Sherine E. Thomas, William J. McCarthy, Jamal El Bakali, Karen P. Brown, So Yeon Kim, Michal Blaszczyk, Vítor Mendes, Chris Abell, R. Andres Floto, Anthony G. Coyne, Tom L. Blundell
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Anti-microbial resistance is a rising global healthcare concern that needs urgent attention as growing number of infections become difficult to treat with the currently available antibiotics. This is particularly true for mycobacterial infections lik
Externí odkaz:
https://doaj.org/article/2ec45fe855c2444086e1ec68c5424f59
Autor:
Vitor Mendes, Simon R. Green, Joanna C. Evans, Jeannine Hess, Michal Blaszczyk, Christina Spry, Owain Bryant, James Cory-Wright, Daniel S-H. Chan, Pedro H. M. Torres, Zhe Wang, Navid Nahiyaan, Sandra O’Neill, Sebastian Damerow, John Post, Tracy Bayliss, Sasha L. Lynch, Anthony G. Coyne, Peter C. Ray, Chris Abell, Kyu Y. Rhee, Helena I. M. Boshoff, Clifton E. Barry, Valerie Mizrahi, Paul G. Wyatt, Tom L. Blundell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The bifunctional enzyme CoaBC catalyses the second and third step in the Coenzyme A (CoA) biosynthesis pathway and is of interest as a M. tuberculosis drug target. Here, the authors present the full-length crystal structure of Mycobacterium smegmatis
Externí odkaz:
https://doaj.org/article/dfbd7ac1fa2f42d49910fcdc7940c42e
Autor:
Pooja Gupta, Sherine E. Thomas, Shaymaa A. Zaidan, Maria A. Pasillas, James Cory-Wright, Víctor Sebastián-Pérez, Ailidh Burgess, Emma Cattermole, Clio Meghir, Chris Abell, Anthony G. Coyne, William R. Jacobs, Jr., Tom L. Blundell, Sangeeta Tiwari, Vítor Mendes
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 3491-3506 (2021)
The L-arginine biosynthesis pathway consists of eight enzymes that catalyse the conversion of L-glutamate to L-arginine. Arginine auxotrophs (argB/argF deletion mutants) of Mycobacterium tuberculosis are rapidly sterilised in mice, while inhibition o
Externí odkaz:
https://doaj.org/article/0589d4fe9fbe444192900ca3afd6da59
Autor:
Mona M. Katariya, Matthew Snee, Richard B. Tunnicliffe, Madeline E. Kavanagh, Helena I. M. Boshoff, Cecilia N. Amadi, Colin W. Levy, Andrew W. Munro, Chris Abell, David Leys, Anthony G. Coyne, Kirsty J. McLean
Funder: Division of Intramural Research, National Institute of Allergy and Infectious Diseases; Id: http://dx.doi.org/10.13039/100006492
Funder: Cambridge Trust; Id: http://dx.doi.org/10.13039/501100003343
Mycobacterium tuberculosis (Mtb) w
Funder: Cambridge Trust; Id: http://dx.doi.org/10.13039/501100003343
Mycobacterium tuberculosis (Mtb) w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::139d9139a1ac4d5afba661d0322e8c46
https://www.repository.cam.ac.uk/handle/1810/347549
https://www.repository.cam.ac.uk/handle/1810/347549
Autor:
Sitthivut Charoensutthivarakul, Sherine E. Thomas, Amy Curran, Karen P. Brown, Juan M. Belardinelli, Andrew J. Whitehouse, Marta Acebrón-García-de-Eulate, Jaspar Sangan, Subramanian G. Gramani, Mary Jackson, Vitor Mendes, R. Andres Floto, Tom L. Blundell, Anthony G. Coyne, Chris Abell
Publikováno v:
ACS Infectious Diseases. 8:296-309
Publikováno v:
RSC Medicinal Chemistry. 13:392-404
Recently reported inhibitors developed against targets from Mycobacterium absecessus (Mab).
Publikováno v:
Chemical biologydrug designREFERENCES. 100(4)
Fragment-based drug discovery (FBDD) is a method of identifying small molecule hits that can be elaborated rationally through fragment growing, merging and linking, to afford high-affinity ligands for biological targets. Despite the promised theoreti
Autor:
William R. Jacobs, Maria A. Pasillas, Ailidh Burgess, Tom L. Blundell, Sangeeta Tiwari, Anthony G. Coyne, James Cory-Wright, Vitor Mendes, Clio Meghir, Víctor Sebastián-Pérez, Sherine E. Thomas, Shaymaa A. Zaidan, Emma Cattermole, Pooja Gupta, Chris Abell
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 3491-3506 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Computational and Structural Biotechnology Journal
'Computational and Structural Biotechnology Journal ', vol: 19, pages: 3491-3506 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Computational and Structural Biotechnology Journal
'Computational and Structural Biotechnology Journal ', vol: 19, pages: 3491-3506 (2021)
16 p.-8 fig.-4 tab.
The L-arginine biosynthesis pathway consists of eight enzymes that catalyse the conversion of L-glutamate to L-arginine. Arginine auxotrophs (argB/argF deletion mutants) of Mycobacterium tuberculosis are rapidly sterilised in
The L-arginine biosynthesis pathway consists of eight enzymes that catalyse the conversion of L-glutamate to L-arginine. Arginine auxotrophs (argB/argF deletion mutants) of Mycobacterium tuberculosis are rapidly sterilised in
Autor:
Sherine E, Thomas, William J, McCarthy, Jamal, El Bakali, Karen P, Brown, So Yeon, Kim, Michal, Blaszczyk, Vítor, Mendes, Chris, Abell, R Andres, Floto, Anthony G, Coyne, Tom L, Blundell
Publikováno v:
Frontiers in molecular biosciences. 9
Anti-microbial resistance is a rising global healthcare concern that needs urgent attention as growing number of infections become difficult to treat with the currently available antibiotics. This is particularly true for mycobacterial infections lik