Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Anthony E. Getschman"'
Autor:
Michael B. Dwinell, Balaraman Kalyanaraman, Brian F. Volkman, Douglas B. Evans, Dannielle D. Engle, Susan Tsai, Anthony E. Getschman, Noah P. Zimmerman, Clinton T. Piper, Kate Dixon, Egal Gorse, Donna M. McAllister, Ishan Roy
Representative time plot of oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) measurements & migratory and AMPK phosphorylation response to CXCL12 of patient-derived pancreatic cancer cells ; Characterization of murine-derived
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6840f01461f157120d175b2e6e2aefeb
https://doi.org/10.1158/0008-5472.22405089.v1
https://doi.org/10.1158/0008-5472.22405089.v1
Autor:
Francis Lin, Song Liu, Thomas Klonisch, Min Zhao, Xiaoou Ren, David B. Levin, Anthony E. Getschman, Jasmine Cheng, Brian F. Volkman, Samuel T Hwang, Susy Santos
Publikováno v:
Lab Chip
Lab on a chip, vol 21, iss 8
Lab on a chip, vol 21, iss 8
A microfluidics-based three-dimensional skin-on-chip (SoC) model is developed in this study to enable quantitative studies of transendothelial and transepithelial migration of human T lymphocytes in mimicked skin inflammatory microenvironments and to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc5fe54de5945be97768ef32a911635c
https://doi.org/10.1039/d0lc01194k
https://doi.org/10.1039/d0lc01194k
Autor:
Kyler S. Crawford, Anthony E. Getschman, Sarah A. Mahn, John D. McCorvy, Adriano Marchese, Brian F. Volkman, Francis C. Peterson, Michael J. Wedemeyer
Publikováno v:
J Biol Chem
The human chemokine family consists of 46 protein ligands that induce chemotactic cell migration by activating a family of 23 G protein–coupled receptors. The two major chemokine subfamilies, CC and CXC, bind distinct receptor subsets. A sequence m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ef22d7126a36b0876f830090ed17953
https://doi.org/10.1074/jbc.ra120.014244
https://doi.org/10.1074/jbc.ra120.014244
Publikováno v:
ACS Medicinal Chemistry Letters
CXCL12, a CXC-type chemokine, binds its receptor CXCR4, and the resulting signaling cascade is essential during development and subsequently in immune function. Pathologically, the CXCL12-CXCR4 signaling axis is involved in many cancers and inflammat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::538a2518790e0f699cfb2bfdf64166ef
https://pubmed.ncbi.nlm.nih.gov/34795867
https://pubmed.ncbi.nlm.nih.gov/34795867
Autor:
Mimi Nguyen, Xuesong Wu, Mindy Huynh, Siba P. Raychaudhuri, Anthony E. Getschman, Timothy Law, Douglas J. Rowland, Machelle D. Wilson, Smriti Kundu-Raychaudhuri, Zhenrui Shi, Neal L. Millar, Flavia Sunzini, Emma Garcia-Melchor, Samuel T Hwang, Brian F. Volkman, Moeed Akbar
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.)REFERENCES. 73(12)
OBJECTIVE To assess the involvement of the CCR6/CCL20 axis in psoriatic arthritis (PsA) and psoriasis (PsO) and to evaluate its potential as a therapeutic target. METHODS First, we quantified CCL20 levels in peripheral blood and synovial fluid from P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f69a68e09245bd93ebbe2cdc9c8faf8e
https://pubmed.ncbi.nlm.nih.gov/34226726
https://pubmed.ncbi.nlm.nih.gov/34226726
Autor:
Francis C. Peterson, Olav Larsen, Mette M. Rosenkilde, Samuel T Hwang, Brian F. Volkman, Anthony E. Getschman, Yasutomo Imai, Xuesong Wu
Publikováno v:
Proceedings of the National Academy of Sciences. 114:12460-12465
Psoriasis is a chronic inflammatory skin disease characterized by the infiltration of T cell and other immune cells to the skin in response to injury or autoantigens. Conventional, as well as unconventional, γδ T cells are recruited to the dermis a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d5a6d6f0f1ceb656da5eaa823dcc9c
https://doi.org/10.1073/pnas.1704958114
https://doi.org/10.1073/pnas.1704958114
Publikováno v:
Molecular Carcinogenesis. 56:804-813
As knowledge of growth-independent functions of cancer cells is expanding, exploration into the role of chemokines in modulating cancer pathogenesis, particularly metastasis, continues to develop. However, more study into the mechanisms whereby chemo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba25b0b775c3968bee9cee8b7fba0280
https://doi.org/10.1002/mc.22571
https://doi.org/10.1002/mc.22571
Autor:
Olav Larsen, Samuel T Hwang, Anthony E. Getschman, Sarah J. Riutta, Brian F. Volkman, Mette M. Rosenkilde
Publikováno v:
Journal of leukocyte biology. 104(2)
Chemokine–chemokine receptor (CKR) interactions are traditionally described by a two-step/two-site mechanism that details the major contact points between chemokine ligands and CKRs leading to ligand recognition and receptor activation. Chemokine r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a47afba929b3cf1f46df348fc65a86cf
https://pubmed.ncbi.nlm.nih.gov/30114340
https://pubmed.ncbi.nlm.nih.gov/30114340
Autor:
Deni Taleski, Francis C. Peterson, Natasha A. Moussouras, Brian F. Volkman, Andrew J. Phillips, Christopher T. Veldkamp, Richard J. Payne, Anthony E. Getschman, Michael B. Dwinell, Chad A. Koplinski, Amanda M. Richard
Publikováno v:
International Journal of Molecular Sciences; Volume 18; Issue 9; Pages: 1857
International Journal of Molecular Sciences, Vol 18, Iss 9, p 1857 (2017)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 18, Iss 9, p 1857 (2017)
International Journal of Molecular Sciences
Chemokines are secreted proteins that direct the migration of immune cells and are involved in numerous disease states. For example, CCL21 (CC chemokine ligand 21) and CCL19 (CC chemokine ligand 19) recruit antigen-presenting dendritic cells and naï
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1a5aa514ba345102066d2073c54595c
Autor:
Francis C. Peterson, Anthony E. Getschman, Joshua J. Ziarek, Emmanuel W. Smith, Yu Chen, Brian F. Volkman, Rongshi Li, Yan Liu
Publikováno v:
Journal of Medicinal Chemistry
CXCL12 binds to CXCR4, promoting both chemotaxis of lymphocytes and metastasis of cancer cells. We previously identified small molecule ligands that bind CXCL12 and block CXCR4-mediated chemotaxis. We now report a 1.9 Å resolution X-ray structure of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b9a2f1f56f1c5726b15040fceef006f
https://doi.org/10.1021/jm501194p
https://doi.org/10.1021/jm501194p