Výsledky vyhledávání - "Anthony E. Crane"

Molecular dosimetry of DNA adducts in C3H mice treated with glycidaldehyde

Autor: Anthony E. Crane, William P. Watson, Sandra Steiner

Publikováno v: Carcinogenesis. 13:119-124

The formation of DNA adducts in the skin of male C3H mice treated cutaneously with glycidaldehyde (2 or 10 mg/animal) in acetone has been investigated by HPLC coupled with fluorescence detection and 32P-postlabelling analysis. Following a 24 h exposu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da1df115a7b6810c8bfd1cb0bed4a621
https://doi.org/10.1093/carcin/13.1.119

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Formation of ribonucleotides in DNA modified by oxidative damage in vitro and in vivo. Characterization by 32P-postlabeling

Autor: Anthony E. Crane, Kurt Randerath, Tracy F. Danna, Erika Randerath, William P. Watson, Ranjani Reddy

Publikováno v: Mutation research. 275(3-6)

Oxygen free radicals generated by the interaction of Fe2+ and H2O2 (Fenton reaction) are capable of reacting with DNA bases, which may induce premutagenic and precarcinogenic lesions. Products formed in DNA by such reactions have been characterized a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0178fae73f6b06baa51f94d4be36d34f
https://pubmed.ncbi.nlm.nih.gov/1383776

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Synthesis and confirmation of structure of four mammalian metabolites of dieldrin and endrin

Autor: Rosina K. Harrod, Anthony E. Crane, Colin T. Bedford

Publikováno v: Pesticide Science. 17:659-667

The first syntheses of syn-12-hydroxydieldrin, syn-12-hydroxyendrin and anti-12-hydroxyendrin have been accomplished by debenzoylation and epoxidation of three isomeric adduction products of hexachlorocyclopentadiene and 1,7,7-trinorborna-2,5-dien-7-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c1f91c3555364beeb4d0ce55ed72de79
https://doi.org/10.1002/ps.2780170607

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Acetolysis of the trifluoromethanesulphonates of syn-12-hydroxyaldrin and syn-12-hydroxyisodrin and their dihydro derivatives

Autor: Edward H. Smith, Anthony E. Crane, N.K. Wellard, Colin T. Bedford

Publikováno v: Tetrahedron. 41:455-466

Acetolysis rates of the trifluoromethanesulphonates of two geometric isomers of hexachlorotetracyclo[6.2.1.13,6.O2,7]dodeca-4,9-dien-12-ol (6, 8; syn-12-hydroxyaldrin, syn-12-hydroxy-isodrin) and of two geometric isomers of hexachlorotetracyclo[6.2.1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::edec09363d3140bf40dfc8dbef778838
https://doi.org/10.1016/s0040-4020(01)96439-7

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Synthesis of endrin metabolites. Part 2: Total synthesis and confirmation of the structure of 3-hydroxyendrin

Autor: Colin T. Bedford, Edward H. Smith, Nicholas K. Wellard, Anthony E. Crane

Publikováno v: Pesticide Science. 17:33-47

3-Hydroxyendrin, a minor metabolite of endrin in several mammals, has been synthesised for the first time in a three-step procedure. The synthesis is based on the two-step commercial manufacture of endrin, with cyclopenta-1,3-dienyl acetate replacing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9de4c5f2d4bbefba3b92e18a39129f6f
https://doi.org/10.1002/ps.2780170105

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