Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Anthony E Oro"'
Autor:
Samantha N Piekos, Sadhana Gaddam, Pranav Bhardwaj, Prashanth Radhakrishnan, Ramanathan V Guha, Anthony E Oro
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 9, p e1009382 (2021)
The repurposing of biomedical data is inhibited by its fragmented and multi-formatted nature that requires redundant investment of time and resources by data scientists. This is particularly true for Type 1 Diabetes (T1D), one of the most intensely s
Externí odkaz:
https://doaj.org/article/156a7a24928640d481d412773f7836ef
Autor:
Nancy Yanzhe Li, Weiruo Zhang, Daniel Haensel, Anna R. Jussila, Cory Pan, Sadhana Gaddam, Sylvia K. Plevritis, Anthony E. Oro
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Cancer-associated inflammation is a double-edged sword possessing both pro- and anti-tumor properties through ill-defined tumor-immune dynamics. While we previously identified a carcinoma tumor-intrinsic resistance pathway, basal-to-squamous
Externí odkaz:
https://doaj.org/article/88d555228c794b15a0303b41ed1d8731
Autor:
Gernot Neumayer, Jessica L. Torkelson, Shengdi Li, Kelly McCarthy, Hanson H. Zhen, Madhuri Vangipuram, Marius M. Mader, Gulilat Gebeyehu, Taysir M. Jaouni, Joanna Jacków-Malinowska, Avina Rami, Corey Hansen, Zongyou Guo, Sadhana Gaddam, Keri M. Tate, Alberto Pappalardo, Lingjie Li, Grace M. Chow, Kevin R. Roy, Thuylinh Michelle Nguyen, Koji Tanabe, Patrick S. McGrath, Amber Cramer, Anna Bruckner, Ganna Bilousova, Dennis Roop, Jean Y. Tang, Angela Christiano, Lars M. Steinmetz, Marius Wernig, Anthony E. Oro
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract We present Dystrophic Epidermolysis Bullosa Cell Therapy (DEBCT), a scalable platform producing autologous organotypic iPS cell-derived induced skin composite (iSC) grafts for definitive treatment. Clinical-grade manufacturing integrates CRI
Externí odkaz:
https://doaj.org/article/beaa5273b9ae4861a2bf161a05a28b1a
Autor:
Nicole M Urman, Amar Mirza, Scott X Atwood, Ramon J Whitson, Kavita Y Sarin, Jean Y Tang, Anthony E Oro
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168031 (2016)
The Hedgehog pathway is a potent regulator of cellular growth and plays a central role in the development of many cancers including basal cell carcinoma (BCC). The majority of BCCs arise from mutations in the Patched receptor resulting in constitutiv
Externí odkaz:
https://doaj.org/article/50921feb6e1e4b48b58a3590c57c6bd5
Autor:
Jemima L Whyte, Andrew A Smith, Bo Liu, Wilfred R Manzano, Nick D Evans, Girija R Dhamdhere, Mark Y Fang, Howard Y Chang, Anthony E Oro, Jill A Helms
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76883 (2013)
Wnt signaling is required for both the development and homeostasis of the skin, yet its contribution to skin wound repair remains controversial. By employing Axin2(LacZ/+) reporter mice we evaluated the spatial and temporal distribution patterns of W
Externí odkaz:
https://doaj.org/article/76fc897f160d48f3b2837cb6523adc4d
Autor:
Daniel Haensel, Bence Daniel, Sadhana Gaddam, Cory Pan, Tania Fabo, Jeremy Bjelajac, Anna R. Jussila, Fernanda Gonzalez, Nancy Yanzhe Li, Yun Chen, JinChao Hou, Tiffany Patel, Sumaira Aasi, Ansuman T. Satpathy, Anthony E. Oro
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Cancer immunotherapies have revolutionized treatment but have shown limited success as single-agent therapies highlighting the need to understand the origin, assembly, and dynamics of heterogeneous tumor immune niches. Here, we use single-ce
Externí odkaz:
https://doaj.org/article/5e4bc24e6e914f23800da67601a21438
Autor:
Ann E. Collier, Samantha N. Piekos, Angela Liu, Jillian M. Pattison, Franco Felix, Alessandro A. Bailetti, Egor Sedov, Sadhana Gaddam, Hanson Zhen, Anthony E. Oro
Publikováno v:
iScience, Vol 26, Iss 3, Pp 106125- (2023)
Summary: Ectodermal dysplasias including skin abnormalities and cleft lip/palate result from improper surface ectoderm (SE) patterning. However, the connection between SE gene regulatory networks and disease remains poorly understood. Here, we dissec
Externí odkaz:
https://doaj.org/article/afe45ebf4a7949d48c0c76b1a5a59693
Autor:
Ann Collier, Angela Liu, Jessica Torkelson, Jillian Pattison, Sadhana Gaddam, Hanson Zhen, Tiffany Patel, Kelly McCarthy, Hana Ghanim, Anthony E. Oro
Publikováno v:
Nature
Proper ectodermal patterning during human development requires previously identified transcription factors such as GATA3 and p63, as well as positional signaling from regional mesoderm(1–6). However, the mechanism by which ectoderm and mesoderm fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a11c6f93871c70a64bffe5d8af1ef5
https://doi.org/10.1038/s41586-022-04727-9
https://doi.org/10.1038/s41586-022-04727-9
Purpose: To assess the tumor response to the smoothened (SMO) inhibitor, sonidegib (LDE225), in patients with an advanced basal cell carcinoma (BCC) resistant to treatment with vismodegib (GDC0449).Experimental Design: Nine patients with an advanced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cb24b0fc45b177f2527f2c303b066f4
https://doi.org/10.1158/1078-0432.c.6524225
https://doi.org/10.1158/1078-0432.c.6524225
Swimmer's plot showing resistance to vismodegib of study patients.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc734f23bc5eca7abbc639506c522628
https://doi.org/10.1158/1078-0432.22459463
https://doi.org/10.1158/1078-0432.22459463