Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Anthony Dossang"'
Development of a small molecule that corrects misfolding and increases secretion of Z α1‐antitrypsin
Autor:
David A Lomas, James A Irving, Christopher Arico‐Muendel, Svetlana Belyanskaya, Andrew Brewster, Murray Brown, Chun‐wa Chung, Hitesh Dave, Alexis Denis, Nerina Dodic, Anthony Dossang, Peter Eddershaw, Diana Klimaszewska, Imran Haq, Duncan S Holmes, Jonathan P Hutchinson, Alistair M Jagger, Toral Jakhria, Emilie Jigorel, John Liddle, Ken Lind, Stefan J Marciniak, Jeff Messer, Margaret Neu, Allison Olszewski, Adriana Ordonez, Riccardo Ronzoni, James Rowedder, Martin Rüdiger, Steve Skinner, Kathrine J Smith, Rebecca Terry, Lionel Trottet, Iain Uings, Steve Wilson, Zhengrong Zhu, Andrew C Pearce
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 3, Pp 1-16 (2021)
Abstract Severe α1‐antitrypsin deficiency results from the Z allele (Glu342Lys) that causes the accumulation of homopolymers of mutant α1‐antitrypsin within the endoplasmic reticulum of hepatocytes in association with liver disease. We have use
Externí odkaz:
https://doaj.org/article/73075a476ae1421891a994ecbcb35e20
Autor:
Martin Rüdiger, Chun-wa Chung, Jonathan P. Hutchinson, Christopher C. Arico-Muendel, Svetlana L. Belyanskaya, Allison Olszewski, Nerina Dodic, Duncan S. Holmes, Anthony Dossang, Andrew C. Pearce, Alistair M. Jagger, Steve Wilson, Adriana Ordóñez, David A. Lomas, Toral Jakhria, Iain Uings, Hitesh Dave, Zhengrong Zhu, Stefan J. Marciniak, Alexis Denis, Lionel Trottet, Kathrine J. Smith, Murray J. B. Brown, Imran Haq, James A. Irving, Steve Skinner, Margaret Neu, Diana Klimaszewska, Peter Eddershaw, Riccardo Ronzoni, James E. Rowedder, Andrew Brewster, John Liddle, Emilie Jigorel, Jeffrey A. Messer, Ken Lind, Rebecca Terry
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 13, Iss 3, Pp n/a-n/a (2021)
EMBO Molecular Medicine, Vol 13, Iss 3, Pp n/a-n/a (2021)
Severe α1‐antitrypsin deficiency results from the Z allele (Glu342Lys) that causes the accumulation of homopolymers of mutant α1‐antitrypsin within the endoplasmic reticulum of hepatocytes in association with liver disease. We have used a DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e32df3c3fc2fd491449ec31b9633ea9
https://doi.org/10.15252/emmm.202013167
https://doi.org/10.15252/emmm.202013167
Autor:
John, Liddle, Andrew C, Pearce, Christopher, Arico-Muendel, Svetlana, Belyanskaya, Andrew, Brewster, Murray, Brown, Chun-Wa, Chung, Alexis, Denis, Nerina, Dodic, Anthony, Dossang, Peter, Eddershaw, Diana, Klimaszewska, Imran, Haq, Duncan S, Holmes, Alistair, Jagger, Toral, Jakhria, Emilie, Jigorel, Ken, Lind, Jeff, Messer, Margaret, Neu, Allison, Olszewski, Riccardo, Ronzoni, James, Rowedder, Martin, Rüdiger, Steve, Skinner, Kathrine J, Smith, Lionel, Trottet, Iain, Uings, Zhengrong, Zhu, James A, Irving, David A, Lomas
Publikováno v:
Bioorganicmedicinal chemistry letters. 41
α1-antitrypsin deficiency is characterised by the misfolding and intracellular polymerisation of mutant α1-antitrypsin protein within the endoplasmic reticulum (ER) of hepatocytes. Small molecules that bind and stabilise Z α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bfbd08c9f4609860ae0edd678ca66212
https://pubmed.ncbi.nlm.nih.gov/33753261
https://pubmed.ncbi.nlm.nih.gov/33753261
Development of a small molecule that corrects misfolding and increases secretion of Z α1-antitrypsin
Autor:
Stefan J. Marciniak, Martin Rüdiger, Hitesh Dave, Jonathan P. Hutchinson, Margaret Neu, Anthony Dossang, Riccardo Ronzoni, Lionel Trottet, Adriana Ordóñez, Chun-wa Chung, Christopher C. Arico-Muendel, Alexis Denis, Allison Olszewski, Andrew C. Pearce, Ken Lind, Peter Eddershaw, Andrew Brewster, Rebecca Terry, Jeffrey A. Messer, John Liddle, Iain Uings, Emilie Jigorel, James A. Irving, Nerina Dodic, Zhengrong Zhu, Kathrine J. Smith, Duncan S. Holmes, Steve Skinner, Steve Wilson, David A. Lomas, Diana Klimaszewska, James E. Rowedder, Murray J. B. Brown, Alistair M. Jagger, Toral Jakhria, Imran Haq, Svetlana L. Belyanskaya
Severe α1-antitrypsin deficiency results from the Z allele (Glu342Lys) that causes the accumulation of homopolymers of mutant α1-antitrypsin within the endoplasmic reticulum of hepatocytes in association with liver disease. We have used a DNA-encod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af5dc4b6dd1fbecffcf82db1f278226c
https://doi.org/10.1101/2020.07.26.217661
https://doi.org/10.1101/2020.07.26.217661
Autor:
Lionel Trottet, Martin Rüdiger, Anthony Dossang, Alexis Denis, David A. Lomas, James A. Irving, Andrew C. Pearce, Andrew Brewster, John Liddle, Zhengrong Zhu, Peter Eddershaw, James E. Rowedder, Kathrine J. Smith, Chun-wa Chung, Ken Lind, Christopher C. Arico-Muendel, Jeffrey A. Messer, Allison Olszewski, Diana Klimaszewska, Murray J. B. Brown, Nerina Dodic, Duncan S. Holmes, Imran Haq, Alistair M. Jagger, Toral Jakhria, Steve Skinner, Margaret Neu, Riccardo Ronzoni, Emilie Jigorel, Iain Uings, Svetlana L. Belyanskaya
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 41:127973
α1-antitrypsin deficiency is characterised by the misfolding and intracellular polymerisation of mutant α1-antitrypsin protein within the endoplasmic reticulum (ER) of hepatocytes. Small molecules that bind and stabilise Z α1-antitrypsin were iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d246fffa8ad97002689f34f62901b59
https://doi.org/10.1016/j.bmcl.2021.127973
https://doi.org/10.1016/j.bmcl.2021.127973
Autor:
Natalie Page, Matthew Helm, Anthony Dossang, Colin O'Dowd, Jakub T. Flasz, Elias Arkoudis, Keeva McClelland, Gerald Gavory, Ewa Odrzywol, Eamon Cassidy, Oliver Barker, Tim Harrison, Caroline Hughes, Hugues Miel
Publikováno v:
Gavory, G, O'Dowd, C, Helm, M D, Flasz, J, Arkoudis, E, Dossang, A, Hughes, C, Cassidy, E, McClelland, K, Odrzywol, E, Page, N, Barker, O, Miel, H & Harrison, T 2017, ' Discovery and characterization of highly potent and selective allosteric USP7 inhibitors ', Nature Chemical Biology, vol. 14, pp. 118-125 . https://doi.org/10.1038/nchembio.2528
Given the importance of ubiquitin-specific protease 7 (USP7) in oncogenic pathways, identification of USP7 inhibitors has attracted considerable interest. Despite substantial efforts, however, the development of validated deubiquitinase (DUB) inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d54bd60b0c724b11afde133cd0d60a09
https://pure.qub.ac.uk/en/publications/discovery-and-characterization-of-highly-potent-and-selective-allosteric-usp7-inhibitors(e7597a0f-932a-40c7-93ad-632aa359463e).html
https://pure.qub.ac.uk/en/publications/discovery-and-characterization-of-highly-potent-and-selective-allosteric-usp7-inhibitors(e7597a0f-932a-40c7-93ad-632aa359463e).html
Autor:
Colin O'Dowd, Adam Treder, Eamon Cassidy, Joana Costa, Christina Bell, Ashling Henderson, Gerald Gavory, Oliver Barker, Ewelina Rozycka, Matt Helm, Timothy Harrison, Natalie Page, Frank Burkamp, Mary McFarland, Anthony Dossang, Mark Wappett, Steven Shepherd, Hugues Miel, Peter Hewitt, Stephanie Burton, Caroline Hughes, Shane Rountree, Lauren Proctor, Steven Whitehead
Publikováno v:
Cancer Research. 78:1935-1935
Over the past decade, protein ubiquitination has emerged as an important post-translational modification with regulatory functions in all important cellular processes. Deubiquitinating enzymes (DUBs) including ubiquitin specific proteases (USPs) are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aadcc8acfb17ff79c7e20112a76d2c81
https://doi.org/10.1158/1538-7445.am2018-1935
https://doi.org/10.1158/1538-7445.am2018-1935
Autor:
Matt Helm, Elias Arkoudis, Caroline Hughes, Jakub T. Flasz, Ewa Odrzywol, Colin O'Dowd, Gerald Gavory, Natalie Page, Eamon Cassidy, Keeva McClelland, Hugues Miel, Oliver Barker, Tim Harrison, Anthony Dossang
Publikováno v:
Cancer Research. 78:4869-4869
Given the importance of USP7 in known oncogenic pathways and its emerging role in immuno-oncology, the identification of USP7 inhibitors has attracted considerable interest in the scientific community. However, despite substantial efforts over the pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::369e45d6c4c01955b51cd4bbf0a0f259
https://doi.org/10.1158/1538-7445.am2018-4869
https://doi.org/10.1158/1538-7445.am2018-4869
Autor:
Ewelina Rozycka, Oliver Barker, Joana Costa, Ashling Henderson, Caroline Hughes, Peter Hewitt, Gerald Gavory, Tim Harrison, Anthony Dossang, Colin O'Dowd, Mary McFarland, Lauren Proctor, Hugues Miel
Publikováno v:
Cancer Research. 77:1181-1181
Over the past decade, protein ubiquitination has emerged as an important post-translational modification with regulatory functions in all important cellular processes. Deubiquitinating enzymes (DUBs) including ubiquitin specific proteases (USPs) are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81e68da27c8aa7f5976ab157b48cef2e
https://doi.org/10.1158/1538-7445.am2017-1181
https://doi.org/10.1158/1538-7445.am2017-1181