Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Anthony Donofrio"'
Autor:
Michael Wleklinski, Paige M. Carpenter, Kevin D. Dykstra, Anthony Donofrio, Timothy Nowak, Shane W. Krska, Ronald D. Ferguson
Publikováno v:
SLAS Technology, Vol 29, Iss 2, Pp 100126- (2024)
High-throughput experimentation (HTE) has become more widely utilized in drug discovery for rapid reaction optimization and generation of large synthetic compound arrays. While this has accelerated medicinal chemistry design, make, test (DMT) iterati
Externí odkaz:
https://doaj.org/article/551f9a876fc040d694b69bd9e46488ad
Autor:
Chunhui Huang, Christian Fischer, Michelle R. Machacek, Stephane Bogen, Tesfaye Biftu, Xianhai Huang, Michael H. Reutershan, Ryan Otte, Qingmei Hong, Zhicai Wu, Yang Yu, Min Park, Lei Chen, Purakkattle Biju, Ian Knemeyer, Ping Lu, Christopher J. Kochansky, Michael Brendan Hicks, Yong Liu, Roy Helmy, Xavier Fradera, Anthony Donofrio, Josh Close, Matthew L. Maddess, Catherine White, David L. Sloman, Nunzio Sciammetta, Jun Lu, Craig Gibeau, Vladimir Simov, Hongjun Zhang, Peter Fuller, David Witter
Publikováno v:
ACS Med Chem Lett
[Image: see text] Mutant isocitrate dehydrogenase 1 (IDH1) has been identified as an attractive oncology target for which >70% of grade II and III gliomas and ∼10% of acute myeloid leukemia (AML) harbor somatic IDH1 mutations. These mutations confe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ecfd534a4182e5c705a82b16c3ffcc
https://europepmc.org/articles/PMC9014435/
https://europepmc.org/articles/PMC9014435/
Autor:
Charlie Chang, Zhengwei Peng, Anthony Donofrio, Meir Glick, Scott T. Harrison, Brian R. Lahue
Publikováno v:
Future Medicinal Chemistry. 9:533-536
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::149ecb98fe3614a83a048a54f7cb83ca
https://doi.org/10.4155/fmc-2017-0025
https://doi.org/10.4155/fmc-2017-0025
Autor:
Jie Zhang-Hoover, Chaomin Li, Erin F. Mulrooney, Christian Fischer, Alan B. Northrup, Melanie A. Kleinschek, Jeremy Presland, Brian M. Andresen, Anthony Donofrio, Jason D. Brubaker, Matthew Lloyd Childers, Thierry O. Fischmann, Jongwon Lim, Alexander Hicks, Sue Jin, James Baker, Lilly Y. Moy, Hongmin Chen, Antoaneta S. Necheva, Luis E. Torres, Ruojing Yang, Michael D. Altman, Craig R. Gibeau, Duan Liu, Heidi Ferguson, Charles A. Lesburg, John Maclean, Erica Leccese, Faruk Mansoor, Graham Smith, Sam Kattar, Yiping Chen, Larissa Rakhilina
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(12)
Interleukin-1 receptor associated kinase 4 (IRAK4) has been implicated in IL-1R and TLR based signaling. Therefore selective inhibition of the kinase activity of this protein represents an attractive target for the treatment of inflammatory diseases.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53b65eb508a6ab7e6105827a694eda1d
https://pubmed.ncbi.nlm.nih.gov/28501511
https://pubmed.ncbi.nlm.nih.gov/28501511
Publikováno v:
Pastoral Psychology. 61:71-83
This research sought to explore whether a normative profile on the MMPI-2 emerged for counseling students in a counselor training program at a seminary in the Midwest and the extent to which this profile compares to those proposed for counseling stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d2a98b1ddd9c598bec6e76bed529d66
https://doi.org/10.1007/s11089-011-0373-4
https://doi.org/10.1007/s11089-011-0373-4
Autor:
Sheila M. Galloway, Binyuan Sun, Nancy Kelly, John W. Butcher, Grace H. C. Woo, Kerrie Spencer, J. Michael Ellis, Ryan D. Otte, Ekundayo Osimboni, Alan S. Bass, Sandra Lee, J. Richard Miller, Chiming Yang, Erica Leccese, Andrew M. Haidle, Alan B. Northrup, Lily Y. Moy, James P. Jewell, Alan Byford, Hani Houshyar, Gwendolyn J. Ward, Anthony Donofrio, Matthew L. Maddess, Michael D. Altman, M. Vijay Reddy, Stella H. Vincent
Publikováno v:
Journal of medicinal chemistry. 58(4)
Development of a series of highly kinome-selective spleen tyrosine kinase (Syk) inhibitors with favorable druglike properties is described. Early leads were discovered through X-ray crystallographic analysis, and a systematic survey of cores within a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::040b080e82842dc9548a30636c5cf5d6
https://pubmed.ncbi.nlm.nih.gov/25625541
https://pubmed.ncbi.nlm.nih.gov/25625541
Autor:
Cathy Huml, Jean-Marc Fontaine, Anthony Donofrio, Rainer Benndorf, Stéphanie Simon, Jody L. Martin, Patrick Vicart
Publikováno v:
The FASEB Journal. 21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bee252204d3c6abe437272111d567a7b
https://doi.org/10.1096/fasebj.21.6.a1358-d
https://doi.org/10.1096/fasebj.21.6.a1358-d
Publikováno v:
The FASEB Journal. 20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd13c4404937ebce44c78b6d59ed7dba
https://doi.org/10.1096/fasebj.20.4.a385-b
https://doi.org/10.1096/fasebj.20.4.a385-b