Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Anthony DeBlasio"'
Autor:
Stephen D. Nimer, Anthony DeBlasio, Kazunori Murata, Delphine Ndiaye-Lobry, Martin Fleisher, Takashi Asai, Elena M. Cortizas, Chen Lossos, John H.J. Petrini, Ramiro E. Verdun, Megan A. Hatlen
Publikováno v:
Scientific Reports
Multiple myeloma is a plasma cell neoplasm with an extremely variable clinical course. Animal models are needed to better understand its pathophysiology and for preclinical testing of potential therapeutic agents. Hematopoietic cells expressing the h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1010fa6928b64dcc29f27eb16a0df374
Autor:
Fabiana Perna, Fan Liu, Hao Xu, Priya Koppikar, Stephen D. Nimer, Silvia Menendez, Lan Wang, Ayalew Tefferi, Ross L. Levine, Michael W. Harr, Megan A. Hatlen, Anthony DeBlasio, Omar Abdel-Wahab, Xinyang Zhao
Publikováno v:
Cancer Cell. 19(2):283-294
SummaryThe JAK2V617F constitutively activated tyrosine kinase is found in most patients with myeloproliferative neoplasms. While examining the interaction between JAK2 and PRMT5, an arginine methyltransferase originally identified as JAK-binding prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e19ace20a3b70fda95c6c9f05bc30861
Autor:
Shifeng Mao, H. Daniel Lacorazza, Yasushi Miyazaki, Stephen D. Nimer, Pier Paolo Pandolfi, Anthony DeBlasio, Antonio Di Cristofano, Carlos Cordon-Cardo, Cyrus V. Hedvat, Jin Zhang
Publikováno v:
Immunity. 17(4):437-449
We utilized gene targeting by homologous recombination to define the role that MEF, a transcriptional activating member of the ETS family of transcription factors, plays in lymphopoiesis. MEF−/− mice have a profound reduction in the number of NK-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0ba1a058ac47f18029a4014053655c
Publikováno v:
The Journal of Cell Biology
Proliferation of some cultured human tumor cell lines bearing high numbers of epidermal growth factor (EGF) receptors is paradoxically inhibited by EGF in nanomolar concentrations. In the present study, we have investigated the biochemical mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b4d224761c67cfef43dc57f5c20cb21
https://doi.org/10.1083/jcb.131.1.235
https://doi.org/10.1083/jcb.131.1.235
Autor:
Youyang Yang, Ingo K. Mellinghoff, Fan Liu, Goro Sashida, Hao Yu, Zhenbang Chen, Xinyang Zhao, Anthony DeBlasio, Stephen D. Nimer, Silvia Menendez, Qing-Bai She, Yan Liu, Neal Rosen, Hui Kuan Lin, Cyrus V. Hedvat, Shannon Elf, Pier Paolo Pandolfi, Gang Huang, Michael W. Harr, Silvana Di Giandomenico, Yasuhiko Miyata
Publikováno v:
Science signaling. 5(247)
The Polycomb group protein Bmi1 is a transcriptional silencer of the Ink4a-Arf locus, which encodes the cell cycle regulator p16(Ink4a) and the tumor suppressor p19(Arf). Bmi1 plays a key role in oncogenesis and stem cell self-renewal. We report that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6141af01377c32aadbc38afa8144fdb0
https://pubmed.ncbi.nlm.nih.gov/23092893
https://pubmed.ncbi.nlm.nih.gov/23092893
Autor:
Stanley R. Frankel, Anthony DeBlasio, Raymond P. Warrell, Ethan Dmitrovsky, Wilson H. Miller, Kristi Levine
Publikováno v:
Blood. 82:1689-1694
The characteristic reciprocal translocation t(15;17) of acute promyelocytic leukemia (APL) disrupts the PML gene on chromosome 15 and the retinoic acid receptor-alpha (RAR-alpha) gene on chromosome 17. PML/RAR-alpha fusion mRNAs are then transcribed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb31ac9b03405c8759ebdb1ff47089c7
https://doi.org/10.1182/blood.v82.6.1689.1689
https://doi.org/10.1182/blood.v82.6.1689.1689
Autor:
Boris Reva, Goro Sashida, Anthony DeBlasio, Andrew Koff, Silvana Di Giandomenico, Yasuhiko Miyata, Gang Huang, Shannon Elf, Jack Antipin, Yan Liu, Yuhui Liu, Jennifer May Lee, Stephen D. Nimer, Silvia Menendez
Publikováno v:
Cell stem cell. 4(1)
SummaryThe importance of the p53 protein in the cellular response to DNA damage is well known, but its function during steady-state hematopoiesis has not been established. We have defined a critical role of p53 in regulating hematopoietic stem cell q
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a2a9029039edd2e0a703f7e29a2fe4
https://pubmed.ncbi.nlm.nih.gov/19128788
https://pubmed.ncbi.nlm.nih.gov/19128788
Autor:
Pier Paolo Pandolfi, Elizabeth Calleja, Diane Corso, Anthony DeBlasio, Laura J. Dardashti, Zhugang Wang, Janice Gabrilove, Steven L. Soignet, Raymond P. Warrell, Suresh C. Jhanwar, Peter Maslak, David A. Scheinberg
Publikováno v:
The New England journal of medicine. 339(19)
Two reports from China have suggested that arsenic trioxide can induce complete remissions in patients with acute promyelocytic leukemia (APL). We evaluated this drug in patients with APL in an attempt to elucidate its mechanism of action.Twelve pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ec24c5bbd0602ec6794b0b0f42fc16
https://pubmed.ncbi.nlm.nih.gov/10189286
https://pubmed.ncbi.nlm.nih.gov/10189286
Autor:
Stephen D. Nimer, Rachel Wevrick, Yan Liu, Anthony DeBlasio, Boris Reva, Silvia Menendez, Jack Antipin, Takashi Asai, Silvana Di Giandomenico
Publikováno v:
Blood. 114:379-379
Abstract 379 Necdin, a member of MAGE (melanoma antigen) family proteins, is a growth suppressing protein that was first identified in post mitotic neurons. The gene encoding necdin is one of several deleted in individuals with Prader-Willi syndrome,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2b30cae74000857d687f3af7327070c
https://doi.org/10.1182/blood.v114.22.379.379
https://doi.org/10.1182/blood.v114.22.379.379
Autor:
Yan Liu, Anthony DeBlasio, Yasuhiko Miyata, Stephen D. Nimer, Silvia Menendez, Vladimir Jankovic, Shannon Elf, Goro Sashida
Publikováno v:
Blood. 110:1273-1273
The relative quiescence of adult hematopoietic stem cells (HSCs) at steady state represents an important regulatory mechanism for maintaining their self-renewal and engraftment capacity, as well as their resistance to cytotoxic insults. However, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::684953fe5c68ad3b4ae21d66a10723a8
https://doi.org/10.1182/blood.v110.11.1273.1273
https://doi.org/10.1182/blood.v110.11.1273.1273