Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Anthony D. Sercel"'
Autor:
H. D. Hollis Showalter, André Michel, Marlatt Mark Eugene, Boguslawa Leja, Vladimir Genukh Beylin, Anthony D. Sercel
Publikováno v:
Journal of Heterocyclic Chemistry. 43:1597-1604
Short, efficient pathways are described for the synthesis of racemic 2-nitroimidazole radiation sensitizer RB-6145 (2a) and each of its corresponding (R)- and (S)-enantiomers (2b and 2c, respectively). The synthesis of each enantiomer commences with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ca416288603a6a606408ad5ff1d163d
https://doi.org/10.1002/jhet.5570430625
https://doi.org/10.1002/jhet.5570430625
Publikováno v:
Journal of Heterocyclic Chemistry. 43:701-707
Starting from a series of 2-bromo-1-methylindole precursors (1b-e) activated in the 3-position with aldehyde, ester, or amide functionality, two approaches have been developed toward the synthesis of 2,2′-bis(indolyl)ethynes and reduced congeners v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ca264cef415082432b7384d3370b3ca
https://doi.org/10.1002/jhet.5570430326
https://doi.org/10.1002/jhet.5570430326
Autor:
Anthony D. Sercel, John B. Randolph, Kee-Yong Jung, Dean S. Wise, Hugh Mackie, Robert L. Somers, William H. Pearson, David A. Berry
Publikováno v:
Tetrahedron Letters. 45:2457-2461
Pyrrolo-dC ( 1a , 6-methyl-3-(2-deoxy-β- d -ribofuranosyl)-3 H -pyrrolo[2,3- d ]pyrimidin-2-one) and its cyanoethyl phosphoramidite 2a were synthesized. The latter was incorporated into oligodeoxyribonucleotides by standard automated synthesis techn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4569e09edd30329b614b60d28056198c
https://doi.org/10.1016/j.tetlet.2004.01.108
https://doi.org/10.1016/j.tetlet.2004.01.108
Autor:
Anthony D. Sercel, Carla Suto, H. D. Hollis Showalter, Judith Leopold, William L. Elliott, Wilbur R. Leopold, R. Thomas Winters
Publikováno v:
ChemInform. 45
The synthesis of a small series of 2-nitroimidazoles in which the β-amino alcohol side chain was amidated with a range of alkylating/acylating functionality is described. Synthetic methodologies were developed that generally provided for selective N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b66731221eaa3c6068ffeefa9fe03f39
https://doi.org/10.1002/chin.201432146
https://doi.org/10.1002/chin.201432146
Autor:
H. D. Hollis Showalter, Anthony D. Sercel, R. Thomas Winters, William L. Elliott, Judith Leopold, Carla Suto, Wilbur R. Leopold
Publikováno v:
Chemicalpharmaceutical bulletin. 62(3)
The synthesis of a small series of 2-nitroimidazoles in which the β-amino alcohol side chain was amidated with a range of alkylating/acylating functionality is described. Synthetic methodologies were developed that generally provided for selective N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9823e138c2f070822c542614ddadfedd
https://pubmed.ncbi.nlm.nih.gov/24583786
https://pubmed.ncbi.nlm.nih.gov/24583786
Publikováno v:
Journal of Heterocyclic Chemistry. 38:961-964
Approaches toward the preparative-scale synthesis of target 3,4-dihydro-1(2H)-isoquinolinones 1–3 are presented. Compounds 1 and 2 were prepared via a Schmidt rearrangement on easily obtained indanone precursors, but in low overall yield. A better
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ac81954acf60b3b589a6dfdeb469a7c
https://doi.org/10.1002/jhet.5570380424
https://doi.org/10.1002/jhet.5570380424
Autor:
Maruta Boyd, Brian D. Palmer, H. D. Hollis Showalter, William A. Denny, Anthony D. Sercel, Alan J. Kraker, David W. Fry, Andrew M. Thompson, Gordon W. Rewcastle
Publikováno v:
Journal of Medicinal Chemistry. 38:58-67
A series of 3-substituted 2,2'-dithiobis(1H-indoles) were synthesized and evaluated for their ability to inhibit the tyrosine kinase activity of both the epidermal growth factor receptor (EGFR) and the nonreceptor pp60 v-src tyrosine kinase, to exten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeeeff5000838790586fc5ad87d64632
https://doi.org/10.1021/jm00001a011
https://doi.org/10.1021/jm00001a011
Publikováno v:
ChemInform. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38ea131490cd25fdebe8c5693c3c10af
https://doi.org/10.1002/chin.200150132
https://doi.org/10.1002/chin.200150132
Publikováno v:
ChemInform. 37
Starting from a series of 2-bromo-1-methylindole precursors (1b-e) activated in the 3-position with aldehyde, ester, or amide functionality, two approaches have been developed toward the synthesis of 2,2′-bis(indolyl)ethynes and reduced congeners v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32ba06397c48baac6d56e2095bab040f
https://doi.org/10.1002/chin.200644121
https://doi.org/10.1002/chin.200644121
Publikováno v:
The Journal of organic chemistry. 70(18)
[structure: see text] Nucleoside phosphoramidites bearing a fluorous dimethoxytrityl (FDMT) group were used to synthesize fluorous-tagged oligonucleotides, which were subjected to solid-phase extraction using a pH-stable fluorinated adsorbent. On-col
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56486933463643a6546c2fb00e4deb64
https://pubmed.ncbi.nlm.nih.gov/16122230
https://pubmed.ncbi.nlm.nih.gov/16122230