Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Anthony D. Morielli"'
Publikováno v:
Behavioral neuroscience. 135(3)
Cerebellar metabotropic glutamate receptor 1 (mGluR1) expressed by Purkinje cells may play an important role in learning-related cerebellar plasticity. Eyeblink conditioning (EBC) is a well-studied form of Pavlovian learning that engages discrete are
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e68475 (2013)
Caenorhabditis elegans (C. elegans) is an attractive animal model for biological and biomedical research because it permits relatively easy genetic dissection of cellular pathways, including insulin/IGF-like signaling (IIS), that are conserved in mam
Externí odkaz:
https://doaj.org/article/80b85a408f4c48e692c8d2e5546d2b7f
Publikováno v:
FEBS Open Bio
Insulin signaling plays a central role in the regulation of facilitative glucose transporters (GLUTs) in humans. To establish Caenorhabditis elegans (C. elegans) as a model to study the mechanism underlying insulin regulation of GLUT, we identified t
Cerebellar learning modulates surface expression of a voltage-gated ion channel in cerebellar cortex
Publikováno v:
Neurobiology of learning and memory. 142
Numerous experiments using ex vivo electrophysiology suggest that mammalian learning and memory involves regulation of voltage-gated ion channels in terms of changes in function. Yet, little is known about learning-related regulation of voltage-gated
Publikováno v:
Behavioral neuroscience. 130(6)
Protein kinase M zeta (PKM-ζ), a constitutively active N-terminal truncated form of PKC-ζ, has long been implicated in a cellular correlate of learning, long-term potentiation (LTP). Inhibition of PKM-ζ with zeta-inhibitory peptide (ZIP) has been
Publikováno v:
Journal of Dairy Science. 95:1188-1197
Glucose is an essential substrate for lactose synthesis and an important energy source in milk production. Glucose uptake in the mammary gland, therefore, plays a critical role in milk synthesis. Facilitative glucose transporters (GLUT) mediate gluco
Publikováno v:
Experimental Cell Research. 317:2333-2341
The voltage-gated potassium channel, Kv1.3, plays an important role in regulating membrane excitability in diverse cell types ranging from T-lymphocytes to neurons. In the present study, we test the hypothesis that the C-terminal PDZ binding domain m
Dual Roles for RHOA/RHO-Kinase In the Regulated Trafficking of a Voltage-sensitive Potassium Channel
Publikováno v:
Molecular Biology of the Cell. 20:2991-3002
Kv1.2 is a member of the Shaker family of voltage-sensitive potassium channels and contributes to regulation of membrane excitability. The electrophysiological activity of Kv1.2 undergoes tyrosine kinase-dependent suppression in a process involving R
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 295:R733-R740
Kv1.3 channels are known to modulate many aspects of neuronal function. We tested the hypothesis that Kv1.3 modulates the function of postganglionic sympathetic neurons. RT-PCR, immunoblot, and immunohistochemical analyses indicated that Kv1.3 channe
Publikováno v:
Journal of Biological Chemistry. 283:3445-3453
The Shaker family potassium channel, Kv1.2, is a key determinant of membrane excitability in neurons and cardiovascular tissue. Kv1.2 is subject to multiple forms of regulation and therefore integrates cellular signals involved in the homeostasis of