Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Anthony D. Baughn"'
Autor:
Tetsuya Komatsu, Kenji Ohya, Atsushi Ota, Yukiko Nishiuchi, Hirokazu Yano, Kayoko Matsuo, Justice Opare Odoi, Shota Suganuma, Kotaro Sawai, Akemi Hasebe, Tetsuo Asai, Tokuma Yanai, Hideto Fukushi, Takayuki Wada, Shiomi Yoshida, Toshihiro Ito, Kentaro Arikawa, Mikihiko Kawai, Manabu Ato, Anthony D. Baughn, Tomotada Iwamoto, Fumito Maruyama
Publikováno v:
One Health, Vol 16, Iss , Pp 100559- (2023)
Mycobacterium avium subsp. hominissuis (MAH) is one of the most prevalent mycobacteria causing non-tuberculous mycobacterial disease in humans and animals. Of note, MAH is a major cause of mycobacterial granulomatous mesenteric lymphadenitis outbreak
Externí odkaz:
https://doaj.org/article/fa545e9671b24772ba793d7bbe897c2f
Autor:
Joshua M. Thiede, Nicholas A. Dillon, Michael D. Howe, Ranee Aflakpui, Samuel J. Modlin, Sven E. Hoffner, Faramarz Valafar, Yusuke Minato, Anthony D. Baughn
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT Pyrazinamide (PZA) plays a crucial role in first-line tuberculosis drug therapy. Unlike other antimicrobial agents, PZA is active against Mycobacterium tuberculosis only at low pH. The basis for this conditional drug susceptibility remains u
Externí odkaz:
https://doaj.org/article/8ee355f2a62d421f881cdc358d63bc6d
Autor:
Samuel J. Modlin, Afif Elghraoui, Deepika Gunasekaran, Alyssa M. Zlotnicki, Nicholas A. Dillon, Nermeeta Dhillon, Norman Kuo, Cassidy Robinhold, Carmela K. Chan, Anthony D. Baughn, Faramarz Valafar
Publikováno v:
mSystems, Vol 6, Iss 6 (2021)
ABSTRACT Accurate and timely functional genome annotation is essential for translating basic pathogen research into clinically impactful advances. Here, through literature curation and structure-function inference, we systematically update the functi
Externí odkaz:
https://doaj.org/article/d38fb0ef6dbc4db38915e5bc82ff5dd4
Autor:
Elise A. Lamont, Anthony D. Baughn
Publikováno v:
EBioMedicine, Vol 49, Iss , Pp 374-380 (2019)
Pyrazinamide remains the only drug in the tuberculosis pharmacopeia to drastically shorten first-line therapy from nine to six months. Due to its unparalleled ability to sterilize non-replicating bacilli and reduce relapse rates, PZA is expected to b
Externí odkaz:
https://doaj.org/article/033d8f93b9244004be5c341125c8ed5e
Autor:
Yusuke Minato, Surendra Dawadi, Shannon L. Kordus, Abiram Sivanandam, Courtney C. Aldrich, Anthony D. Baughn
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
The antibiotics trimethoprim (TMP) and sulfamethoxazole (SMX) synergistically inhibit bacterial tetrahydrofolate biosynthesis, apparently because SMX potentiates TMP activity. Here, Minato et al. identify a metabolic feedback loop in this pathway, re
Externí odkaz:
https://doaj.org/article/693c54c67db3481ba3a9bc7c7cdf3759
Autor:
Nicholas A. Dillon, Nicholas D. Peterson, Heather A. Feaga, Kenneth C. Keiler, Anthony D. Baughn
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract Pyrazinamide (PZA) is a first line anti-tubercular drug for which the mechanism of action remains unresolved. Recently, it was proposed that the active form of PZA, pyrazinoic acid (POA), disrupts the ribosome rescue process of trans-transla
Externí odkaz:
https://doaj.org/article/4da58e057f364be4a086d7bff82b17a5
Autor:
Yusuke Minato, Daryl M. Gohl, Joshua M. Thiede, Jeremy M. Chacón, William R. Harcombe, Fumito Maruyama, Anthony D. Baughn
Publikováno v:
mSystems, Vol 4, Iss 4 (2019)
ABSTRACT A better understanding of essential cellular functions in pathogenic bacteria is important for the development of more effective antimicrobial agents. We performed a comprehensive identification of essential genes in Mycobacterium tuberculos
Externí odkaz:
https://doaj.org/article/ad5d108f32c64e50b9dd00178fb3a8e5
Autor:
Michael D. Howe, Shannon L. Kordus, Malcolm S. Cole, Allison A. Bauman, Courtney C. Aldrich, Anthony D. Baughn, Yusuke Minato
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
para-Aminosalicylic acid (PAS) is a second-line anti-tubercular drug that is used for the treatment of drug-resistant tuberculosis (TB). PAS efficacy in the treatment of TB is limited by its lower potency against Mycobacterium tuberculosis relative t
Externí odkaz:
https://doaj.org/article/4245dd97c2cc47328c586d12bec19087
Autor:
Yusuke Minato, Anthony D. Baughn
Publikováno v:
mBio, Vol 8, Iss 6 (2017)
Externí odkaz:
https://doaj.org/article/68fbb77b2f2c466aada0f5967b1e8d05
Autor:
Scott I. Brody, Joseph A. Buonomo, Moyosore O. Orimoloye, Ziyi Jia, Sachin Sharma, Christopher D. Brown, Anthony D. Baughn, Courtney C. Aldrich
Publikováno v:
ChemBioChem. 24