Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Anthony D Buss"'
Autor:
Philip J. Sidebottom, Jesus Cortes, Ines U Böhm, Graham Foster, Michael J. Dawson, Peter F. Leadlay, James Staunton, Andrew P. Blackaby, David J Cooper, Barrie Wilkinson, Nicholas L. Taylor, Brian A.M. Rudd, Anthony D Buss, Christine J Rowe, Sabine Gaisser
Publikováno v:
Chemistry & Biology. (2):111-117
Background: The macrolide antibiotic erythromycin A, like other complex aliphatic polyketides, is synthesised by a bacterial modular polyketide synthase (PKS). Such PKSs, in contrast to other fatty acid and polyketide synthases which work iteratively
Autor:
Peter F. Leadlay, Graham Foster, Ylva Roddis, Brian A.M. Rudd, Andrew P. Blackaby, Barrie Wilkinson, Ines U Böhm, Christine J Rowe, James Staunton, Iain P Thomas, Anthony D Buss, Philip J. Sidebottom
Publikováno v:
Chemistry & Biology. (5):475-485
Background: Modular polyketide synthases catalyse the biosynthesis of medically useful natural products by stepwise chain assembly, with each module of enzyme activities catalysing a separate cycle of polyketide chain extension. Domain swapping betwe
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :243
Ethyldiphenylphosphine oxide reacts with butyl-lithium and benzaldehyde to give the title compound which eliminates diphenylphosphinate ion in base to give Z-1 -phenylpropene. The elimination is stereo-specific and syn. The (1RS,2RS) isomer, prepared