Zobrazeno 1 - 10
of 857
pro vyhledávání: '"Anthony D, Ho"'
Dies ist ein Open Access Buch. Wir haben immer mehr Alte, immer weniger Kinder. Dank wissenschaftlicher Fortschritte verlängert sich die Lebenserwartung ständig. Erkenntnisse aus der Naturwissenschaft in der post-genomischen Ära deuten darauf, da
Autor:
Maria-Luisa Schubert, Anita Schmitt, Angela Hückelhoven-Krauss, Brigitte Neuber, Alexander Kunz, Philip Waldhoff, Dominik Vonficht, Schayan Yousefian, Lea Jopp-Saile, Lei Wang, Felix Korell, Anna Keib, Birgit Michels, Dominik Haas, Tim Sauer, Patrick Derigs, Andreas Kulozik, Joachim Kunz, Petra Pavel, Sascha Laier, Patrick Wuchter, Johann Schmier, Gesine Bug, Fabian Lang, Nicola Gökbuget, Jochen Casper, Martin Görner, Jürgen Finke, Andreas Neubauer, Mark Ringhoffer, Denise Wolleschak, Monika Brüggemann, Simon Haas, Anthony D. Ho, Carsten Müller-Tidow, Peter Dreger, Michael Schmitt
Publikováno v:
Journal of Hematology & Oncology, Vol 16, Iss 1, Pp 1-17 (2023)
Abstract Background Third-generation chimeric antigen receptor (CAR)-engineered T cells (CARTs) might improve clinical outcome of patients with B cell malignancies. This is the first report on a third-generation CART dose-escalating, phase-1/2 invest
Externí odkaz:
https://doaj.org/article/26e8df351a78481d84b79ca3e21d57c8
Autor:
Sabine Kayser, David Martínez-Cuadrón, Rebeca Rodriguez-Veiga, Mathias Hänel, Mar Tormo, Kerstin Schäfer-Eckart, Carmen Botella, Friedrich Stölzel, Teresa Bernal del Castillo, Ulrich Keller, Carlos Rodriguez-Medina, Gerhard Held, Maria-Luz Amigo, Christoph Schliemann, Mercedes Colorado, Martin Kaufmann, Manuel Barrios Garcia, Stefan W. Krause, Martin Görner, Edgar Jost, Björn Steffen, Sven Zukunft, Uwe Platzbecker, Anthony D. Ho, Claudia D. Baldus, Hubert Serve, Carsten Müller-Tidow, Christian Thiede, Martin Bornhäuser, Pau Montesinos, Christoph Röllig, Richard F. Schlenk
Publikováno v:
Haematologica, Vol 108, Iss 8 (2023)
We retrospectively studied 97 acute myeloid leukemia patients with trisomy 19 (median age at diagnosis 57 years; range, 17- 83 years) treated between 2001 and 2019 within two multicenter study groups. Trisomy 19 occurred alone in ten (10.5%) patients
Externí odkaz:
https://doaj.org/article/31bde89fd8cf4147a028bc0c80771b36
Autor:
Sabine Kayser, David Martínez-Cuadrón, Maher Hanoun, Friedrich Stölzel, Cristina Gil, H. Christian Reinhardt, Eliana Aguiar, Kerstin Schäfer-Eckart, Juan Miguel Bergua Burgues, Björn Steffen, Teresa Bernal, Stefan W. Krause, Rosalía Riaza, Christoph Schliemann, Jose Cervera, Martin Kaufmann, Laura Torres-Miñana, Mathias Hänel, Evelyn Acuña-Cruz, Edgar Jost, Jesus Lorenzo Algarra, Martina Crysandt, Lars Fransecky, Javier Cornago-Navascues, Sabrina Kraus, Joaquin Martinez-Lopez, Hermann Einsele, Dirk Niemann, Andreas Neubauer, Ruth Seggewiß-Bernhardt, Sebastian Scholl, Stefan A. Klein, Christoph Schmid, Markus Schaich, Martin Schmidt-Hieber, Sven Zukunft, Anthony D. Ho, Uwe Platzbecker, Claudia D. Baldus, Carsten Müller-Tidow, Christian Thiede, Martin Bornhäuser, Hubert Serve, Mark Levis, Pau Montesinos, Christoph Röllig, Richard F. Schlenk
Publikováno v:
Haematologica, Vol 108, Iss 1 (2022)
We retrospectively studied 125 patients with acute myeloid leukemia and trisomy 4 (median age at diagnosis, 58 years; range, 16-77 years) treated between 2000 and 2019 within a multicenter study. Trisomy 4 was the sole abnormality in 28 (22%) patient
Externí odkaz:
https://doaj.org/article/e4e11f5318024c99a75f248fe4ef3498
Autor:
Julia Franzen, Theodoros Georgomanolis, Anton Selich, Chao-Chung Kuo, Reinhard Stöger, Lilija Brant, Melita Sara Mulabdić, Eduardo Fernandez-Rebollo, Clara Grezella, Alina Ostrowska, Matthias Begemann, Miloš Nikolić, Björn Rath, Anthony D. Ho, Michael Rothe, Axel Schambach, Argyris Papantonis, Wolfgang Wagner
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Julia Franzen et al. investigate if changes in DNA methylation at specific genetic loci during cell culture expansion are due to a specific mechanism or gradual deregulation of an epigenetic state. Their results suggest that changes in CpG methylatio
Externí odkaz:
https://doaj.org/article/5d5f8f022ec24a2b9fe369de12508d55
Autor:
Sabine Kayser, Chiara Sartor, Marlise R. Luskin, Jonathan Webster, Fabio Giglio, Nydia Panitz, Andrew M. Brunner, Matthias Fante, Christoph Lutz, Daniel Wolff, Anthony D. Ho, Mark J. Levis, Richard F. Schlenk, Cristina Papayannidis
Publikováno v:
Haematologica, Vol 107, Iss 9 (2022)
Acute lymphoblastic leukemia (ALL) can relapse in the extramedullary compartment, with or without medullary involvement. Response to treatment may be individual. We evaluated response to inotuzumab ozogamicin in 31 patients with relapsed/refractory B
Externí odkaz:
https://doaj.org/article/f86b6a61e1a74dddac2a7c3f1b432bb8
Autor:
Mathias Witzens-Harig, Andreas Viardot, Ulrich Keller, Julia Wosniok, Oliver Deuster, Jennifer Klemmer, Anne-Marie Geueke, Julia Meißner, Anthony D. Ho, Johannes Atta, Reinhard Marks, Paul La Rosée, Christian Buske, Martin H. Dreyling, Georg Hess
Publikováno v:
HemaSphere, Vol 5, Iss 10, p e636 (2021)
There is a high need for novel treatment options in relapsed and refractory diffuse large B-cell lymphoma. Single agent mammalian target of rapamycin (mTOR) inhibitor treatment has shown promising efficacy in this entity. Here, we report on the resul
Externí odkaz:
https://doaj.org/article/f4caec53eac240f28b2e2b6f489f18d4
Autor:
Sabine Kayser, Michael Kramer, David Martínez-Cuadrón, Justin Grenet, Klaus H. Metzeler, Zuzana Sustkova, Marlise R. Luskin, Andrew M. Brunner, Michelle A. Elliott, Cristina Gil, Sandra Casal Marini, Zdeněk Ráčil, Petr Cetkovsky, Jan Novak, Alexander E. Perl, Uwe Platzbecker, Friedrich Stölzel, Anthony D. Ho, Christian Thiede, Richard M. Stone, Christoph Röllig, Pau Montesinos, Richard F. Schlenk, Mark J. Levis
Publikováno v:
Haematologica, Vol 107, Iss 4 (2021)
The aim of this study was to evaluate the prognostic impact of FLT3-ITD in core-binding factor acute myeloid leukemia (CBFAML) in an international, multicenter survey of 97 patients of whom 52% had t(8;21)(q22;q22) and 48% had inv(16)(p13q22)/t(16;16
Externí odkaz:
https://doaj.org/article/c3c97e55fc3e4a1fa419553897fbc384
Autor:
Sabine Kayser, Robert K. Hills, Marlise R. Luskin, Andrew M. Brunner, Christine Terré, Jörg Westermann, Kamal Menghrajani, Carole Shaw, Maria R. Baer, Michelle A. Elliott, Alexander E. Perl, Zdeněk Ráčil, Jiri Mayer, Pavel Zak, Tomas Szotkowski, Stéphane de Botton, David Grimwade, Karin Mayer, Roland B. Walter, Alwin Krämer, Alan K. Burnett, Anthony D. Ho, Uwe Platzbecker, Christian Thiede, Gerhard Ehninger, Richard M. Stone, Christoph Röllig, Martin S. Tallman, Elihu H. Estey, Carsten Müller-Tidow, Nigel H. Russell, Richard F. Schlenk, Mark J. Levis
Publikováno v:
Haematologica, Vol 105, Iss 1 (2020)
Acute myeloid leukemia (AML) with t(6;9)(p22;q34) is a distinct entity accounting for 1-2% of AML cases. A substantial proportion of these patients have a concomitant FLT3-ITD. While outcomes are dismal with intensive chemotherapy, limited evidence s
Externí odkaz:
https://doaj.org/article/0f6f067246d842ec9f1f02982bdc9c76
Autor:
Marco L. Hennrich, Natalie Romanov, Patrick Horn, Samira Jaeger, Volker Eckstein, Violetta Steeples, Fei Ye, Ximing Ding, Laura Poisa-Beiro, Mang Ching Lai, Benjamin Lang, Jacqueline Boultwood, Thomas Luft, Judith B. Zaugg, Andrea Pellagatti, Peer Bork, Patrick Aloy, Anne-Claude Gavin, Anthony D. Ho
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
Ageing causes an inability to replace damaged tissue. Here, the authors perform proteomics analyses of human haematopoietic stem cells and other cells in the bone marrow niche at different ages and show changes in central carbon metabolism, reduced b
Externí odkaz:
https://doaj.org/article/86524845718d4cb59745f4c377ff0da5