Výsledky vyhledávání - "Anthony D'Ippolito"

Akademický článek

Erythroid lineage chromatin accessibility maps facilitate identification and validation of NFIX as a fetal hemoglobin repressor

Autor: Mudit Chaand, Chris Fiore, Brian Johnston, Anthony D’Ippolito, Diane H. Moon, John P. Carulli, Jeffrey R. Shearstone

Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-9 (2023)

Abstract Human genetics has validated de-repression of fetal gamma globin (HBG) in adult erythroblasts as a powerful therapeutic paradigm in diseases involving defective adult beta globin (HBB)1. To identify factors involved in the switch from HBG to

Externí odkaz: https://doaj.org/article/b3930ed08ff74686802ee60965e48080

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Akademický článek

Treatment of pediatric closed femoral shaft fractures: A decline in use of external fixators over the last decade

Autor: Joseph Anthony Ippolito, Gerard F Marciano, Sanjeev Sabharwal

Publikováno v: Journal of Limb Lengthening & Reconstruction, Vol 3, Iss 2, Pp 107-114 (2017)

Background: Femoral fractures represent 2% of all fractures in children. While external fixation was popular for managing pediatric closed femoral shaft fractures, other methods have recently increased in popularity. The purpose of this study was to

Externí odkaz: https://doaj.org/article/81598b7c4b65477f9a2c94137a3fd174

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Improved Sequence Analysis of Intact Proteins by Parallel Ion Parking during Electron Transfer Dissociation

Autor: Maria C. Panepinto, Scott A. Ugrin, John E. P. Syka, Christopher Mullen, Robert Anthony D’Ippolito, Jeffrey Shabanowitz, Donald F. Hunt, Elizabeth M. Duselis, A. Michelle English

Publikováno v: Anal Chem

Electron transfer dissociation (ETD) is an analytically useful tool for primary structure interrogation of intact proteins, but its utility is limited by higher-order reactions with the products. To inhibit these higher-order reactions, first-generat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1eb8a4ecd6def1e14570206d61d2418
https://doi.org/10.1021/acs.analchem.1c03652

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Sequencing a Bispecific Antibody by Controlling Chain Concentration Effects When Using an Immobilized Nonspecific Protease

Autor: Dina L. Bai, Robert Anthony D’Ippolito, Maria C. Panepinto, Keira E. Mahoney, Jeffrey Shabanowitz, Donald F. Hunt

Publikováno v: Anal Chem

Complete sequence coverage of monospecific antibodies was previously achieved using immobilized aspergillopepsin I in a single LC-MS/MS analysis. Bispecific antibodies are asymmetrical compared to their monospecific antibody counterparts, resulting i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83c10b1fcd41cb013dcf27771d72ec1f
https://doi.org/10.1021/acs.analchem.0c01126

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High-altitude adaptation and incipient speciation in geladas

Survival at high altitude requires adapting to extreme conditions such as environmental hypoxia. To understand high-altitude adaptations in a primate, we assembled the genome of the gelada (Theropithecus gelada), an endemic Ethiopian monkey, and comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::52af895ecc25a9fc63bd3807ccd3327d
https://doi.org/10.1101/2021.09.01.458582

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Protamines from liverwort are produced by post-translational cleavage and C-terminal di-aminopropanelation of several male germ-specific H1 histones

Autor: Donald F. Hunt, Juan Ausió, Takashi Ueda, Dina L. Bai, Manjinder S. Cheema, Jeffrey Shabanowitz, Ciro Rivera-Casas, José M. Eirín-López, Robert Anthony D’Ippolito, Naoki Minamino, Harold E. Kasinsky

Publikováno v: J Biol Chem

Protamines are small, highly-specialized, arginine-rich, and intrinsically-disordered chromosomal proteins that replace histones during spermiogenesis in many organisms. Previous evidence supports the notion that, in the animal kingdom, these protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33b4bd0d97248950edf64dbbf6e191c3
https://doi.org/10.1074/jbc.ra119.010316

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Unambiguous Sequence Characterization of a Monoclonal Antibody in a Single Analysis Using a Nonspecific Immobilized Enzyme Reactor

Autor: Jeffrey Shabanowitz, Maria C. Panepinto, Robert Anthony D’Ippolito, Donald F. Hunt, Dina L. Bai, Wei-Han Wang, Joshua D. Hinkle

Publikováno v: Anal Chem

Accurate sequence characterization is essential for the development of therapeutic antibodies by the pharmaceutical industry. Presented here is a methodology to obtain comprehensive sequence analysis of a monoclonal antibody. An enzyme reactor of imm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e4116bc438cf8c09948b2e84180b024
https://doi.org/10.1021/acs.analchem.9b02666

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518MO Tolerability and preliminary clinical activity of SY-5609, a highly potent and selective oral CDK7 inhibitor, in patients with advanced solid tumors

Autor: Babar Bashir, M. Rosario, Graeme Hodgson, L. Zhu, H. Jolin, Erika Hamilton, Dejan Juric, Debra L. Richardson, V. Klimek, M. Kelly, N. Ke, D. Roth, Kyri Papadopoulos, Geoffrey I. Shapiro, C. Madigan, S.H. Henry, Anthony D'Ippolito, Manish Sharma

Publikováno v: Annals of Oncology. 32:S587-S588

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4be157b4da6ad970b838d01ced733ef5
https://doi.org/10.1016/j.annonc.2021.08.1040

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Interlaboratory study for characterizing monoclonal antibodies by top-down and middle-down mass spectrometry

Autor: Sam Hughes, Nicolas L. Young, David Clarke, Frank Sobott, Anja Resemann, Kristina Srzentić, Kim F. Haselmann, Detlev Suckau, Dina L. Bai, Young Ah Goo, Christian Malosse, Mathieu Dupré, Sylvester M. Greer, Neil R. Quebbemann, Ziqing Lin, Jared B. Shaw, Alain Beck, Yury O. Tsybin, Stuart Pengelley, Timothy K. Toby, Lidong He, Paul O. Danis, Henrique S. Seckler, Robert Anthony D’Ippolito, Natalia Gasilova, Jeffrey N. Agar, Donald F. Hunt, Jennifer S. Brodbelt, Matthew V. Holt, Simone Nicolardi, Joseph A. Loo, Yuri E. M. van der Burgt, Nicholas D. Schmitt, Laure Menin, Robert J. Millikin, Ljiljana Paša-Tolić, David R. Goodlett, Mowei Zhou, Joshua D. Hinkle, Michael R. Shortreed, Christopher L. Hendrickson, Wendy Sandoval, Richa Sarin, Jeffrey Shabanowitz, Alan G. Marshall, Anton N. Kozhinov, Neil L. Kelleher, Chad R. Weisbrod, Lissa C. Anderson, Julia Chamot-Rooke, Yunqiu Chen, John R. Yates, Luca Fornelli, Konstantin O. Nagornov, Lloyd M. Smith, Sneha Chatterjee, Ying Ge, Sung Hwan Yoon, Jolene K. Diedrich, Norelle C. Wildburger

Publikováno v: Journal of The American Society for Mass Spectrometry
Journal of The American Society for Mass Spectrometry, Springer Verlag (Germany), 2020, 31 (9), pp.1783-1802. ⟨10.1021/jasms.0c00036⟩
Journal of the American Society for Mass Spectrometry
Journal of the American Society for Mass Spectrometry, vol 31, iss 9
Journal of The American Society for Mass Spectrometry, 31(9), 1783-1802. AMER CHEMICAL SOC
J Am Soc Mass Spectrom
Journal of The American Society for Mass Spectrometry, 2020, 31 (9), pp.1783-1802. ⟨10.1021/jasms.0c00036⟩

International audience; The Consortium for Top-Down Proteomics (www.topdownproteomics.org) launched the present study to assess the current state of top-down mass spectrometry (TD MS) and middle-down mass spectrometry (MD MS) for characterizing monoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce93ac618ef03bef2381fe00d09bf9cf
https://hdl.handle.net/1887/3182316

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