Glutathione depletion and carbon ion radiation potentiate clustered DNA lesions, cell death and prevent chromosomal changes in cancer cells progeny.

Autor: Maïté Hanot, Anthony Boivin, Céline Malésys, Michaël Beuve, Anthony Colliaux, Nicolas Foray, Thierry Douki, Dominique Ardail, Claire Rodriguez-Lafrasse

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e44367 (2012)

Poor local control and tumor escape are of major concern in head-and-neck cancers treated by conventional radiotherapy or hadrontherapy. Reduced glutathione (GSH) is suspected of playing an important role in mechanisms leading to radioresistance, and

Externí odkaz: https://doaj.org/article/e7aba624e6cd456aa3bdf4366f45073f

Different Mechanisms of Cell Death in Radiosensitive and Radioresistant P53 Mutated Head and Neck Squamous Cell Carcinoma Cell Lines Exposed to Carbon Ions and X-Rays

Autor: Olivier Chapet, Michael Beuve, Marcel Bajard, Claire Rodriguez-Lafrasse, Anthony Colliaux, Selena Trajkovic-Bodennec, Priscillia Battiston-Montagne, Mira Maalouf, Claudia Fournier, Isabelle Testard, Gersende Alphonse, Gisela Taucher-Scholz

Publikováno v: International Journal of Radiation Oncology-Biology-Physics
International Journal of Radiation Oncology-Biology-Physics, Elsevier, 2009, 74, pp.200-209. ⟨10.1016/j.ijrobp.2009.01.012⟩
International Journal of Radiation Oncology, Biology, Physics
International Journal of Radiation Oncology, Biology, Physics, 2009, 74, pp.200-209. ⟨10.1016/j.ijrobp.2009.01.012⟩

Purpose We initiated studies on the mechanisms of cell death in head and neck squamous cell carcinoma cell lines (HNSCC) since recent clinical trials have shown that local treatment of HNSCC by carbon hadrontherapy is less efficient than it is in oth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e3e2b861a50d8308fe37141dae659b
https://doi.org/10.1016/j.ijrobp.2009.01.012

Statistical effects of dose deposition in track-structure modelling of radiobiology efficiency

Autor: Etienne Testa, Michael Beuve, Djamel Dabli, Anthony Colliaux, Gerard Montarou, Denis Dauvergne, Benoit Gervais

Publikováno v: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Elsevier, 2009, 267, pp.983-988. ⟨10.1016/j.nimb.2009.02.016⟩
The Seventh International Symposium on Swift Heavy Ions in Matter
The Seventh International Symposium on Swift Heavy Ions in Matter, Jun 2008, Lyon, France. pp.983-988, ⟨10.1016/j.nimb.2009.02.016⟩
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2009, 267, pp.983-988. ⟨10.1016/j.nimb.2009.02.016⟩

Ion-induced cell killing has been reported to depend on the irradiation dose but also on the projectile parameters. In this paper we focus on two approaches developed and extensively used to predict cell survival in response to ion irradiation: the L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc73d86101c35867d2da8c24926c6e8b
http://arxiv.org/abs/0902.4297

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