Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Anthony Casarez"'
Autor:
Heiner Schuetz, Anthony Casarez, Robert Lowell Simmons, Folkert Reck, Guido Koch, Sandro Nocito, Markus Furegati
Publikováno v:
Organic Process Research & Development. 24:1244-1253
The new potentially best-in-class β-lactamase inhibitor IID572 was discovered by a late-stage functionalization approach. An alternative synthesis was developed to satisfy the short-term material n...
Autor:
Cindy Li, Xu Zang, Vijay Sethuraman, Xiaoyu Shen, Johanne Blais, Heinz E. Moser, Kyuto Tashiro, Ellie Growcott, Ramadevi Prathapam, Anthony Casarez, Aregahegn Yifru, Charles Vitt, David McKenney, Tsuyoshi Uehara, Patrick J Rudewicz, Fengxia Li, Hongqiu Guo, Adriana K. Jones, Louis E. Metzger, Wanben Gong, Jacob Shaul, Alun Bermingham, Taryn Cariaga, Richard Colvin, Xiaodong Lin, Dita M. Rasper, Mika Lindvall, Dazhi Tang, Vladimir Capka, Steven Whitebread, Sara Lopez, Meiliana Tjandra, Qingming Zhu, Nancy Turner, Robert Lowell Simmons, Charles R. Dean, Alex Fekete, Folkert Reck
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:748-755
Metallo-β-lactamases (MBLs), such as New Delhi metallo-β-lactamase (NDM-1) have spread world-wide and present a serious threat. Expression of MBLs confers resistance in Gram-negative bacteria to all classes of β-lactam antibiotics, with the except
Autor:
Heinz E. Moser, Cindy Li, Mika Lindvall, Shengtian Yang, Charles R. Dean, Fiorella Ruggiu, Anthony Casarez, Folkert Reck, Robert Lowell Simmons, Adriana K. Jones, Johanna M. Jansen
Publikováno v:
ACS infectious diseases. 5(10)
Monobactam antibiotic 1 is active against Gram-negative bacteria even though it has a higher molecular weight (MW) than the limit of 600 Da typically applied in designing such compounds. On the bas...
Autor:
Sandro Nocito, Anthony Casarez, Sara Lopez, Cindy Li, Louis E. Metzger, Johanne Blais, Kyuto Tashiro, Charles R. Dean, Kaci Phizackerley, Alun Bermingham, Dazhi Tang, Folkert Reck, Jacob Shaul, Richard Colvin, Markus Furegati, Dita M. Rasper, Robert Lowell Simmons, Luis Gamboa, Qin Yue, Xiaoyu Shen, Ellena Growcott, Flavio Ossola
Publikováno v:
ACS infectious diseases. 5(7)
Resistance in Gram-negative bacteria to β-lactam drugs is mediated primarily by the expression of β-lactamases, and co-dosing of β-lactams with a β-lactamase inhibitor (BLI) is a clinically proven strategy to address resistance. New β-lactamases
Autor:
Richard Colvin, Dita M. Rasper, Johanne Blais, Adriana K. Jones, Ramadevi Prathapam, Alexey Ruzin, Xiaoyu Shen, John Fuller, Anthony Casarez, Jun-Rong Wei, Sara Lopez, Alun Bermingham, Peter Skewes-Cox, Tsuyoshi Uehara, Pramila Tamrakar, David T. Barkan, Fergal Casey, Louis E. Metzger, Mina Mostafavi, Robert Lowell Simmons, Kenneth T. Takeoka, Charles R. Dean, Folkert Reck, Cindy Li, Jacob Shaul
The monobactam scaffold is attractive for the development of new agents to treat infections caused by drug-resistant Gram-negative bacteria because it is stable to metallo-β-lactamases (MBLs). However, the clinically used monobactam aztreonam lacks
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50b6aef2e61e0d9a42ba314a881df917
https://europepmc.org/articles/PMC6153799/
https://europepmc.org/articles/PMC6153799/
Autor:
Johanne Blais, Anthony Casarez, Cindy Li, Jennifer A. Leeds, Alexey Ruzin, Srijan Ranjitkar, Sara Lopez, Charles R. Dean, Folkert Reck, Robert Lowell Simmons
LYS228 is a novel monobactam with potent activity against Enterobacteriaceae. LYS228 is stable to metallo-β-lactamases (MBLs) and serine carbapenemases, including Klebsiella pneumoniae carbapenemases (KPCs), resulting in potency against the majority
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f90062e1b2a8a9fb40967930a69c9051
https://europepmc.org/articles/PMC6153794/
https://europepmc.org/articles/PMC6153794/
Synthesis of 1-amino-2-vinylcyclopropane-1-phosphinates. Conversion of a phosphonate to phosphinates
Autor:
Hyung-Jung Pyun, Mingzhe Ji, Michael O'neil Hanrahan Clarke, Anthony Casarez, Richard W. Pastor, X. Christopher Sheng, Aesop Cho, Choung U. Kim, Maria Fardis
Publikováno v:
Tetrahedron Letters. 53:2360-2363
Conversion of diethyl 1-amino-2-vinylcyclopropanephosphonate to ethyl 1-amino-2-vinylcyclopropanephosphinate was accomplished by using either nucleophilic or electrophilic carbon reagents. Hydrolysis of the phosphonate diethyl ester to the mono acid
Autor:
Hyung-Jung Pyun, Mingzhe Ji, Richard W. Pastor, Aesop Cho, Choung U. Kim, X. Christopher Sheng, Maria Fardis, Anthony Casarez, Michael O'neil Hanrahan Clarke
Publikováno v:
ChemInform. 43
The conversions proceed via mono ester (II) by either nucleophilic or electrophilic alkylation to produce a broad spectrum of amino acid biosteres.
Autor:
Anthony Casarez, Aesop Cho, William E. Delaney, Choung U. Kim, Mingzhe Ji, Xiaowu Chen, Jie Xu, Edward Doerffler, Rowchanak Pakdaman, Hyung-Jung Pyun, Wu Qiaoyin, Michael O'neil Hanrahan Clarke, Mertzman Michael E, Ruby Cai, Tanisha D. Rowe, X. Christopher Sheng
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(3)
A potent and novel class of phosphinic acid derived product-like inhibitors of the HCV NS3/4A protease was discovered previously. Modification of the phosphinic acid and quinoline heterocycle led to GS-9256 with potent cell-based activity and favorab
Publikováno v:
ChemInform. 41
The first enantioselective organocatalytic α-nitroalkylation of aldehydes has been accomplished. The aforementioned process involves the oxidative coupling of an enamine intermediate, generated transiently via condensation of an amine catalyst with