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Autor:
Charles Miller, Myles Lindsay, Thomas P. Zimmerman, James Rebbeor, Rebecca Silverstein, Jennifer A. Hunt, Kenya Stokes, Anthony Caronna, Edward Koepf, Remil Aguda
Publikováno v:
Protein Expression and Purification. 88(1):41-46
TAL6003 is an engineered form of human plasmin under development for thrombolytic therapy. TAL6003 (38.2kDa) contains nine disulfide bonds distributed within and between its two functional domains, a 25.2kDa serine protease domain linked to a 13.0kDa