Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Anthony Carlo"'
Publikováno v:
The AAPS Journal. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f93ac712bbd47ac6b04ad659f302f465
https://doi.org/10.1208/s12248-023-00800-x
https://doi.org/10.1208/s12248-023-00800-x
Autor:
Nandini Chaturbhai Patel, Dafydd R. Owen, Rhonda D. Cardin, Karen J. Coffman, Jean G. Sathish, Devendra K. Rai, Heather Eng, Charlotte Moira Norfor Allerton, Jack C. Lee, Britton Boras, Melissa Avery, Qingyi Yang, Eugene P. Kadar, Anthony Carlo, Annaliesa S. Anderson, Matthew R. Reese, Li Di, Jisun Lee, Lisa Aschenbrenner, Stephen Noell, Lawrence W. Updyke, Martin Pettersson, Scott A. Gibson, Matthew F. Sammons, Al E. Stewart, Yuao Zhu, Alyssa Dantonio, Stephen W. Mason, Brett L. Hurst, Ketan S. Gajiwala, Claire M. Steppan, Liuqing Wei, Patrick Robert Verhoest, Samantha Elizabeth Greasley, Simon Berritt, R. Scott Obach, RoseAnn Ferre, Ravi Shankar P. Singh, Amit S. Kalgutkar, Jonathan J. Novak, Kevin Ogilvie, Wei Liu, Jamison B. Tuttle
Publikováno v:
Science. 374:1586-1593
Path to another drug against COVID-19 The rapid development of vaccines has been crucial in battling the ongoing COVID-19 pandemic. However, access challenges remain, breakthrough infections occur, and emerging variants present increased risk. Develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afda196cafc9555c41b81b6f1866c49a
https://doi.org/10.1126/science.abl4784
https://doi.org/10.1126/science.abl4784
Autor:
Christopher Keefer, Tristan S. Maurer, David A. Tess, Heather Eng, Anthony Carlo, Zhenhong Li, John Litchfield
Publikováno v:
Journal of Medicinal Chemistry. 63:6489-6498
Drug precipitation in the nephrons of the kidney can cause drug-induced crystal nephropathy (DICN). To aid mitigation of this risk in early drug discovery, we developed a physiologically based in silico model to predict DICN in rats, dogs, and humans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1317753305e0bc4b81f1263f1467df8
https://doi.org/10.1021/acs.jmedchem.9b01995
https://doi.org/10.1021/acs.jmedchem.9b01995
Autor:
Palmiscno, Anthony Carlo
In his seminal work Mythologies, Roland Barthes identifies wine as one of the most significant “mythologies” in popular culture, primarily through its transformative property that converts a sign into a signifier. As these “myths” evolve, the
Autor:
Dafydd R, Owen, Charlotte M N, Allerton, Annaliesa S, Anderson, Lisa, Aschenbrenner, Melissa, Avery, Simon, Berritt, Britton, Boras, Rhonda D, Cardin, Anthony, Carlo, Karen J, Coffman, Alyssa, Dantonio, Li, Di, Heather, Eng, RoseAnn, Ferre, Ketan S, Gajiwala, Scott A, Gibson, Samantha E, Greasley, Brett L, Hurst, Eugene P, Kadar, Amit S, Kalgutkar, Jack C, Lee, Jisun, Lee, Wei, Liu, Stephen W, Mason, Stephen, Noell, Jonathan J, Novak, R Scott, Obach, Kevin, Ogilvie, Nandini C, Patel, Martin, Pettersson, Devendra K, Rai, Matthew R, Reese, Matthew F, Sammons, Jean G, Sathish, Ravi Shankar P, Singh, Claire M, Steppan, Al E, Stewart, Jamison B, Tuttle, Lawrence, Updyke, Patrick R, Verhoest, Liuqing, Wei, Qingyi, Yang, Yuao, Zhu
Publikováno v:
Science (New York, N.Y.). 374(6575)
The worldwide outbreak of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic. Alongside vaccines, antiviral therapeutics are an important part of the healthcare response to countering the ongo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::30510d29ff514de1e731667297649f17
https://pubmed.ncbi.nlm.nih.gov/34726479
https://pubmed.ncbi.nlm.nih.gov/34726479
Autor:
Alyssa Dantonio, Heather Eng, Nandini Chaturbhai Patel, Anthony Carlo, Liuqing Wei, Annaliesa S. Anderson, Ravi Shankar P. Singh, Lawrence W. Updyke, Amit S. Kalgutkar, Jamison B. Tuttle, Lisa Aschenbrenner, Simon Berritt, Ketan S. Gajiwala, Jack C. Lee, Devendra K. Rai, Martin Pettersson, Matthew R. Reese, Jisun Lee, Stephen W. Mason, Eugene P. Kadar, RoseAnn Ferre, Melissa Avery, Li Di, Charlotte Moira Norfor Allerton, R. Scott Obach, Scott A. Gibson, Stephen Noell, Patrick Robert Verhoest, Kevin Ogilvie, Jonathan J. Novak, Brett L. Hurst, Dafydd R. Owen, Rhonda D. Cardin, Wei Liu, Yuao Zhu, Karen J. Coffman, Claire M. Steppan, Jean G. Sathish, Samantha Elizabeth Greasley, Matthew F. Sammons, Qingyi Yang, Britton Boras, Al E. Stewart
The worldwide outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become an established global pandemic. Alongside vaccines, antiviral therapeutics are an important part of the he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0de6febfa535f3995194517e34278b9
https://doi.org/10.1101/2021.07.28.21261232
https://doi.org/10.1101/2021.07.28.21261232
Autor:
JianHua Liu, Nicole Grable, Timothy J. Strelevitz, R. Scott Obach, Ciarán N. Cronin, Anthony Carlo
Publikováno v:
Protein Expression and Purification. 179:105769
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::093d39564b2a83a929404cb1b3a19156
https://doi.org/10.1016/j.pep.2020.105769
https://doi.org/10.1016/j.pep.2020.105769
Autor:
JianHua Liu, Anthony Carlo, Ciarán N. Cronin, Nicole Grable, Timothy J. Strelevitz, R. Scott Obach
Publikováno v:
Protein Expression and Purification. 177:105749
Human aldehyde oxidase (AOX) has emerged as a key enzyme activity for consideration in modern drug discovery. The enzyme catalyzes the oxidation of a wide variety of compounds, most notably azaheterocyclics that often form the building blocks of smal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f488fb214c087fd6e3f5d6c27bdcee91
https://doi.org/10.1016/j.pep.2020.105749
https://doi.org/10.1016/j.pep.2020.105749
Autor:
Manthena V.S. Varma, Ravi Visswanathan, David A. Tess, Caitlin Jagla, George Chang, JianHua Liu, Rhys M. Jones, Christopher Keefer, Li Di, John P. Umland, Nathaniel Johnson, Heather Eng, Michael J. Banker, R. Scott Obach, Keith Riccardi, Jillian Racich, Samantha Jordan, Anthony Carlo, Jonathan J. Novak, Jackie Carey, Julie Cianfrogna, Sarah Lazzaro
Publikováno v:
European Journal of Pharmaceutical Sciences. 155:105541
Human liver microsomes (HLM) and human hepatocytes (HHEP) are two common in vitro systems used in metabolic stability and inhibition studies. The comparison between the assays using the two systems can provide mechanistic insights on the interplay of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9c8e4dbb8b1e6762283954eceaec97c
https://doi.org/10.1016/j.ejps.2020.105541
https://doi.org/10.1016/j.ejps.2020.105541
Autor:
Jian Lin, Sumathy Mathialagan, Manthena V.S. Varma, David A. Tess, Anthony Carlo, Emi Kimoto, Mark Niosi, Laurie Tylaska
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 367(2)
High-permeability-low-molecular-weight acids/zwitterions [i.e., extended clearance classification system class 1A (ECCS 1A) drugs] are considered to be cleared by metabolism with a minimal role of membrane transporters in their hepatic clearance. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21ac5f7768c3de61322d1df3c2205d94
https://pubmed.ncbi.nlm.nih.gov/30135178
https://pubmed.ncbi.nlm.nih.gov/30135178