Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Anthony C Gordon"'
Autor:
Anthony C Gordon, Justin D Salciccioli, Dominic C Marshall, Joseph Shalhoub, Matthieu Komorowski
Publikováno v:
BMJ Open, Vol 14, Iss 9 (2024)
Objectives Understanding the burden of disease of sepsis is essential for monitoring the effectiveness of international strategies to improve sepsis care. Our objective was to describe the multinational trend of sepsis-related mortality for the perio
Externí odkaz:
https://doaj.org/article/229e63095a32486f98fd6d37905e89a0
Autor:
John Norrie, Stephen Morris, Daniel Francis McAuley, Bronagh Blackwood, Paul Dark, Matt P Wise, Anthony C Gordon, Kalliopi Kydonaki, Timothy Simon Walsh, David Hope, Christopher Weir, Gavin Perkins, Nazir I Lone, Benedict Creagh-Brown, Julia Boyd, Michael Reade, Richard Anthony Parker, Leanne M Aitken, Valerie J Page, Alasdair MacLullich, Cathrine A McKenzie, Alix Macdonald, Annabel Giddings, Lydia Emerson, Robert Glen
Publikováno v:
BMJ Open, Vol 13, Iss 12 (2023)
Introduction Almost all patients receiving mechanical ventilation (MV) in intensive care units (ICUs) require analgesia and sedation. The most widely used sedative drug is propofol, but there is uncertainty whether alpha2-agonists are superior. The a
Externí odkaz:
https://doaj.org/article/ca882e250b3f4906a633eda573496be4
Autor:
Stephen J Brett, Anthony C Gordon, Christine Norton, Mandy Jones, Caroline M Alexander, Huw R Woodbridge
Publikováno v:
BMJ Open, Vol 13, Iss 11 (2023)
Objectives The objective of this study is to explore patient, relative/carer and clinician perceptions of barriers to early physical rehabilitation in intensive care units (ICUs) within an associated group of hospitals in the UK and how they can be o
Externí odkaz:
https://doaj.org/article/7a0fcef1bd7442cab02e45250944e4cb
Publikováno v:
BMJ Health & Care Informatics, Vol 29, Iss 1 (2022)
Objectives Establishing confidence in the safety of Artificial Intelligence (AI)-based clinical decision support systems is important prior to clinical deployment and regulatory approval for systems with increasing autonomy. Here, we undertook safety
Externí odkaz:
https://doaj.org/article/65094c2fb7cc4a79ad4b911963fb1d1f
Autor:
Peter J Godolphin, David J Fisher, Lindsay R Berry, Lennie P G Derde, Janet V Diaz, Anthony C Gordon, Elizabeth Lorenzi, John C Marshall, Srinivas Murthy, Manu Shankar-Hari, Jonathan A C Sterne, Jayne F Tierney, Claire L Vale
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0270668 (2022)
BackgroundA recent prospective meta-analysis demonstrated that interleukin-6 antagonists are associated with lower all-cause mortality in hospitalised patients with COVID-19, compared with usual care or placebo. However, emerging evidence suggests th
Externí odkaz:
https://doaj.org/article/2a17726258534f749bc1365f6a1b21eb
Autor:
Paul R Mouncey, Alvin Richards-Belle, Karen Thomas, David A Harrison, M Zia Sadique, Richard D Grieve, Julie Camsooksai, Robert Darnell, Anthony C Gordon, Doreen Henry, Nicholas Hudson, Alexina J Mason, Michelle Saull, Chris Whitman, J Duncan Young, François Lamontagne, Kathryn M Rowan, the 65 trial investigators
Publikováno v:
Health Technology Assessment, Vol 25, Iss 14 (2021)
Background: Vasopressors are administered to critical care patients to avoid hypotension, which is associated with myocardial injury, kidney injury and death. However, they work by causing vasoconstriction, which may reduce blood flow and cause other
Externí odkaz:
https://doaj.org/article/7608f160200d4a5d990ce3ec840ec1a1
Autor:
Daniel Francis McAuley, Simon Gates, Duncan Young, Nafisa Boota, Anthony C Gordon, Julian Bion, Dipesh Mistry, Ranjit Lall, Janet Lord, Gavin Perkins, Mervyn Singer, Tony Whitehouse, Scott Regan, Emma Skilton
Publikováno v:
BMJ Open, Vol 11, Iss 2 (2021)
Introduction In 2013, a single-centre study reported the safe use of esmolol in patients with septic shock and tachycardia who required vasopressor therapy for more than 24 hours. Although not powered to detect a change in mortality, marked improveme
Externí odkaz:
https://doaj.org/article/5396d4cabcf54a6ebcddfd73448dbd6a
Autor:
Anthony C Gordon, Shalini Santhakumaran, Farah Al-Beidh, Robert ML Orme, Gavin D Perkins, Mervyn Singer, Daniel F McAuley, Alexina J Mason, Josie K Ward, Kieran P O’Dea, Timothy Felton, Mary Cross, Janis Best-Lane, Jonas Lexow, Ashley Campbell, Deborah Ashby
Publikováno v:
Efficacy and Mechanism Evaluation, Vol 5, Iss 6 (2018)
Background: In septic shock, cardiovascular resuscitation using catecholamine vasopressors and inotropes is standard therapy, but catecholamines have important side effects. Levosimendan (Simdax®; Orion Pharma, Newbury, UK) is a calcium-sensitising
Externí odkaz:
https://doaj.org/article/0fdb3781dce7473aa22a1e9ace439a37
Autor:
Rejina Verghis, Bronagh Blackwood, Cliona McDowell, Philip Toner, Daniel Hadfield, Anthony C Gordon, Mike Clarke, Daniel McAuley
Background: The choice of outcome measure is a critical decision in the design of any clinical trial, but many Phase III clinical trials in critical care fail to detect a difference between the interventions being compared. This may be because the su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c74fdefb9663570f0310da9af75346a
http://hdl.handle.net/10044/1/104421
http://hdl.handle.net/10044/1/104421
Autor:
Hew D Torrance, Ping Zhang, E Rebecca Longbottom, Yuxin Mi, Justin P Whalley, Alice Allcock, Andrew J Kwok, Eddie Cano-Gamez, Cyndi G Geoghegan, Katie L Burnham, David B Antcliffe, Emma E Davenport, Rupert M Pearse, Michael J O’Dwyer, Charles J Hinds, Julian C Knight, Anthony C Gordon
RationaleNosocomial infections are a major healthcare challenge, developing in over 20% of patients aged 45 or over undergoing major-abdominal surgery, with postoperative pneumonia associated with an almost five-fold increase in 30-day mortality.Obje
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdd2e4f71bef884190b5e00574bde0ee
https://doi.org/10.1101/2023.01.25.23284914
https://doi.org/10.1101/2023.01.25.23284914