Aedes aegypti (Aag2)-derived clonal mosquito cell lines reveal the effects of pre-existing persistent infection with the insect-specific bunyavirus Phasi Charoen-like virus on arbovirus replication.

Autor: Anthony C Fredericks, Tiffany A Russell, Louisa E Wallace, Andrew D Davidson, Ana Fernandez-Sesma, Kevin Maringer

Publikováno v: PLoS Neglected Tropical Diseases, Vol 13, Iss 11, p e0007346 (2019)

BackgroundAedes aegypti is a vector mosquito of major public health importance, transmitting arthropod-borne viruses (arboviruses) such as chikungunya, dengue, yellow fever and Zika viruses. Wild mosquito populations are persistently infected at high

Externí odkaz: https://doaj.org/article/b5d34be0e2f5481a8e157d60bc0af54c

An Aedes aegypti-derived Ago2 knockout cell line to investigate arbovirus infections

Autor: Jack Knowles, Ana Fernandez-Sesma, Kevin Maringer, Janina Fuss, Alain Kohl, Andres Merits, Christina Scherer, Esther Schnettler, Margus Varjak, Anthony C. Fredericks, Vattipally B. Sreenu

Publikováno v: Viruses
Volume 13
Issue 6
Viruses, Vol 13, Iss 1066, p 1066 (2021)

Mosquitoes are known as important vectors of many arthropod-borne (arbo)viruses causing disease in humans. These include dengue (DENV) and Zika (ZIKV) viruses. The exogenous small interfering (si)RNA (exo-siRNA) pathway is believed to be the main ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b23a106da6b9534b5766f2c6af767a3f
https://eprints.gla.ac.uk/243364/1/243364.pdf

Aedes aegypti(Aag2)-derived clonal mosquito cell lines reveal impact of pre-existing persistent co-infection with the insect-specific Bunyavirus Phasi Charoen-like virus on arbovirus replication

Autor: Tiffany A. Russell, Andrew D. Davidson, Ana Fernandez-Sesma, Kevin Maringer, Louisa E. Wallace, Anthony C. Fredericks, José M. C. Ribeiro

Publikováno v: Access Microbiology. 1

Background Aedes aegypti is a vector mosquito of major public health importance, transmitting arthropod-borne viruses (arboviruses) such as chikungunya, dengue, yellow fever and Zika viruses. Wild mosquito populations are persistently infected at hig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::90d27db62762ee35e1bf7bc28b11b365
https://doi.org/10.1099/acmi.ac2019.po0588

Aedes aegypti Piwi4 Is a Noncanonical PIWI Protein Involved in Antiviral Responses

Autor: Margus Varjak, Kevin Maringer, Mick Watson, Vattipally B. Sreenu, Anthony C. Fredericks, Emilie Pondeville, Claire L. Donald, Jelle Sterk, Joy Kean, Marie Vazeille, Anna-Bella Failloux, Alain Kohl, Esther Schnettler, W. Paul Duprex

Publikováno v: MSphere
MSphere, American Society for Microbiology., 2017, 2 (3), pp.e00144-17. ⟨10.1128/mSphere.00144-17⟩
MSphere, 2017, 2 (3), pp.e00144-17. ⟨10.1128/mSphere.00144-17⟩
mSphere, Vol 2, Iss 3, p e00144-17 (2017)
mSphere, Vol 2, Iss 3 (2017)
Varjak, M, Maringer, K, Watson, M, Sreenu, V B, Fredericks, A C, Pondeville, E, Donald, C L, Sterk, J, Kean, J, Vazeille, M, Failloux, A, Kohl, A, Schnettler, E & Duprex, W P (ed.) 2017, ' Aedes aegypti Piwi4 Is a Noncanonical PIWI Protein Involved in Antiviral Responses ', mSphere, vol. 2, no. 3, pp. e00144-17 . https://doi.org/10.1128/mSphere.00144-17
mSphere

Mosquitoes transmit several pathogenic viruses, for example, the chikungunya and Zika viruses. In mosquito cells, virus replication intermediates in the form of double-stranded RNA are cleaved by Dcr2 into 21-nucleotide-long siRNAs, which in turn are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50ecc50a7e8e274ca37629cbaf39398f
https://hal-pasteur.archives-ouvertes.fr/pasteur-01573771/document

Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection

Autor: Laurence G. Webb, Anthony C. Fredericks, Ana M. Maestre, Lubbertus C. F. Mulder, Francise Lamothe, Maria Teresa Sánchez-Aparicio, Jenish R. Patel, Ana Fernandez-Sesma, Sebastian Aguirre, Priya Luthra, Tongtong Zhu, Christopher F. Basler, Viviana Simon, Benjamin Greenbaum, Dabeiba Bernal-Rubio, Shashank Tripathi, Jessica Pintado-Silva, Adolfo García-Sastre, Alexander Solovyov

Publikováno v: Nature microbiology. 2

During the last few decades, the global incidence of dengue virus (DENV) has increased dramatically, and it is now endemic in more than 100 countries. To establish a productive infection in humans, DENV uses different strategies to inhibit or avoid t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5752fba5fc6d846cef7251b6e0cd07c
https://pubmed.ncbi.nlm.nih.gov/28346454