Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Anthony Beucher"'
Autor:
Jose M. Ramos-Pittol, Isabel Fernandes-Freitas, Alexandra Milona, Stephen M. Manchishi, Kara Rainbow, Brian Y. H. Lam, John A. Tadross, Anthony Beucher, William H. Colledge, Inês Cebola, Kevin G. Murphy, Irene Miguel-Aliaga, Giles S. H. Yeo, Waljit S. Dhillo, Bryn M. Owen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Coupling the release of pituitary hormones to the developmental stage of the oocyte is essential for female fertility. It requires estrogen to restrain kisspeptin (KISS1)-neuron pulsatility in the arcuate hypothalamic nucleus, while also exe
Externí odkaz:
https://doaj.org/article/59195b68a82445d591a6b19294b35586
Autor:
Goutham Atla, Silvia Bonàs-Guarch, Mirabai Cuenca-Ardura, Anthony Beucher, Daniel J. M. Crouch, Javier Garcia-Hurtado, Ignasi Moran, the T2DSystems Consortium, Manuel Irimia, Rashmi B. Prasad, Anna L. Gloyn, Lorella Marselli, Mara Suleiman, Thierry Berney, Eelco J. P. de Koning, Julie Kerr-Conte, Francois Pattou, John A. Todd, Lorenzo Piemonti, Jorge Ferrer
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-28 (2022)
Abstract Background Non-coding genetic variants that influence gene transcription in pancreatic islets play a major role in the susceptibility to type 2 diabetes (T2D), and likely also contribute to type 1 diabetes (T1D) risk. For many loci, however,
Externí odkaz:
https://doaj.org/article/cf1281e02aac42cea7c15b4711ce5611
Autor:
Tzipi Braun, Katya E. Sosnovski, Amnon Amir, Marina BenShoshan, Kelli L. VanDussen, Rebekah Karns, Nina Levhar, Haya Abbas-Egbariya, Rotem Hadar, Gilat Efroni, David Castel, Camila Avivi, Michael J. Rosen, Anne M. Grifiths, Thomas D. Walters, David R. Mack, Brendan M. Boyle, Syed Asad Ali, Sean R. Moore, Melanie Schirmer, Ramnik J. Xavier, Subra Kugathasan, Anil G. Jegga, Batya Weiss, Chen Mayer, Iris Barshack, Shomron Ben-Horin, Igor Ulitsky, Anthony Beucher, Jorge Ferrer, Jeffrey S. Hyams, Lee A. Denson, Yael Haberman
Publikováno v:
JCI Insight, Vol 8, Iss 14 (2023)
Ulcerative colitis (UC), Crohn’s disease (CD), and celiac disease are prevalent intestinal inflammatory disorders with nonsatisfactory therapeutic interventions. Analyzing patient data-driven cohorts can highlight disease pathways and new targets f
Externí odkaz:
https://doaj.org/article/175d48f8e9c64094a115fe7ffb8e26b5
Autor:
Julie Piccand, Constance Vagne, Florence Blot, Aline Meunier, Anthony Beucher, Perrine Strasser, Mari L. Lund, Sabitri Ghimire, Laure Nivlet, Céline Lapp, Natalia Petersen, Maja S. Engelstoft, Christelle Thibault-Carpentier, Céline Keime, Sara Jimenez Correa, Valérie Schreiber, Nacho Molina, Thue W. Schwartz, Adèle De Arcangelis, Gérard Gradwohl
Publikováno v:
Molecular Metabolism, Vol 29, Iss , Pp 24-39 (2019)
Objective: Enteroendocrine cells (EECs) of the gastro-intestinal tract sense gut luminal factors and release peptide hormones or serotonin (5-HT) to coordinate energy uptake and storage. Our goal is to decipher the gene regulatory networks controllin
Externí odkaz:
https://doaj.org/article/ae5bc94129d345d5a7f7ab5313070cd2
Autor:
Peter J. Arthur-Farraj, Claire C. Morgan, Martyna Adamowicz, Jose A. Gomez-Sanchez, Shaline V. Fazal, Anthony Beucher, Bonnie Razzaghi, Rhona Mirsky, Kristjan R. Jessen, Timothy J. Aitman
Publikováno v:
Cell Reports, Vol 20, Iss 11, Pp 2719-2734 (2017)
Repair Schwann cells play a critical role in orchestrating nerve repair after injury, but the cellular and molecular processes that generate them are poorly understood. Here, we perform a combined whole-genome, coding and non-coding RNA and CpG methy
Externí odkaz:
https://doaj.org/article/b1df5bc580954457aa1f44a8b2ac5ad5
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
The transcriptional programs of differentiated cells are tightly regulated by interactions between cell type-specific transcription factors and cis-regulatory elements. Long non-coding RNAs (lncRNAs) have emerged as additional regulators of gene tran
Externí odkaz:
https://doaj.org/article/968038a22f9f439b81294cdabbc2f58a
Autor:
Anthony Beucher, Elisabet Gjernes, Caitlin Collin, Monica Courtney, Aline Meunier, Patrick Collombat, Gérard Gradwohl
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36449 (2012)
Intestinal hormones are key regulators of digestion and energy homeostasis secreted by rare enteroendocrine cells. These cells produce over ten different hormones including GLP-1 and GIP peptides known to promote insulin secretion. To date, the molec
Externí odkaz:
https://doaj.org/article/c0837999b685493384adbfd4041922c9
Autor:
Isabel Fernandes-Freitas, Alexandra Milona, Jose Ramos-Pittol, Stephen Manchishi, Kara Rainbow, Brian Lam, John Tadross, Anthony Beucher, William Colledge, Ines Cebola, Kevin Murphy, Irene Miguel-Aliaga, Giles Yeo, Waljit Dhillo, Bryn Owen
Publikováno v:
Endocrine Abstracts.
Autor:
Anthony Beucher, Irene Miguel-Escalada, Diego Balboa, Matías G. De Vas, Miguel Angel Maestro, Javier Garcia-Hurtado, Aina Bernal, Roser Gonzalez-Franco, Pierfrancesco Vargiu, Holger Heyn, Philippe Ravassard, Sagrario Ortega, Jorge Ferrer
The biological purpose of long non-coding RNAs (lncRNAs) is poorly understood. Haploinsufficient mutations in HNF1A homeobox A (HNF1A), encoding a homeodomain transcription factor, cause diabetes mellitus. Here, we examine HASTER, the promoter of an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09b9469b975430bdc6550f581cdb41e3
http://hdl.handle.net/10044/1/99697
http://hdl.handle.net/10044/1/99697
Autor:
François Pattou, Anthony Beucher, Julie Kerr-Conte, Ignasi Moran, Anna L. Gloyn, Cuenca-Ardura M, Jorge Ferrer, Javier García-Hurtado, Mara Suleiman, Koning EJPd, Thierry Berney, Irimia M, Lorenzo Piemonti, Goutham Atla, Rashmi B. Prasad, Bonas-Guarch S, Lorella Marselli
Genetic variants that influence transcriptional regulation in pancreatic islets play a major role in the susceptibility to type 2 diabetes (T2D). For many susceptibility loci, however, the mechanisms are unknown. We examined splicing QTLs (sQTLs) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3882b92148c7020a8f696534632fb298
https://doi.org/10.1101/2021.11.11.468254
https://doi.org/10.1101/2021.11.11.468254