Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Anthony B. DeAngelo"'
Autor:
Leah C. Wehmas, Sandra R. Eldridge, Julia H. Carter, Charles E. Wood, Michael H. George, Beena Vallanat, Anna Fisher, Gleta Carswell, Anthony B. DeAngelo, Greg R. Olson, Brian N. Chorley, Susan D. Hester
Publikováno v:
Toxicological Sciences. 159:354-365
Early-life environmental factors can influence later-life susceptibility to cancer. Recent evidence suggests that metabolic pathways may mediate this type of latency effect. Previously, we reported that short-term exposure to dichloroacetic acid (DCA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eb87b3811ecc11a315a7b059c8a1fc2
https://doi.org/10.1093/toxsci/kfx146
https://doi.org/10.1093/toxsci/kfx146
Autor:
Susan D. Hester, Elias T. Gaillard, Tanya Moore, Michael H. George, Charles E. Wood, William O. Ward, Carlin Okerberg, Anthony B. DeAngelo, Anna Fisher, Brian N. Chorley, April D. Lake, Hongzu Ren, Gleta Carswell, Beena Vallanat
Publikováno v:
Carcinogenesis. 36:782-791
Environmental exposures occurring early in life may have an important influence on cancer risk later in life. Here, we investigated carryover effects of dichloroacetic acid (DCA), a small molecule analog of pyruvate with metabolic programming propert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::039d62494e0a2953649a5fa06d27d195
https://doi.org/10.1093/carcin/bgv057
https://doi.org/10.1093/carcin/bgv057
Autor:
Jane Ellen Simmons, Jerome M. Goldman, Anthony B. DeAngelo, Deborah S. Best, E. Sidney Hunter, Juan D. Suarez, Michael H. George, Anthony McDonald, Michael G. Narotsky, Ashley S. Murr, Gary R. Klinefelter, Lillian F. Strader
Publikováno v:
Environmental Health Perspectives
Background Trihalomethanes (THMs) and haloacetic acids (HAAs) are regulated disinfection by-products (DBPs); their joint reproductive toxicity in drinking water is unknown. Objective We aimed to evaluate a drinking water mixture of the four regulated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afb56d9c8c6f123be36295d030a7a375
http://europepmc.org/articles/PMC4455591
http://europepmc.org/articles/PMC4455591
Autor:
Jane Ellen Simmons, Mary P. Moyer, Rebecca Y. Milsk, Bonnie A. Lyon, Anthony B. DeAngelo, Howard S. Weinberg
Publikováno v:
Environmental Science & Technology. 48:6743-6753
As the use of alternative drinking water treatment increases, it is important to understand potential public health implications associated with these processes. The objective of this study was to evaluate the formation of disinfection byproducts (DB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72dbba0cf8c5b6d6408373d17bea57cf
https://doi.org/10.1021/es501412n
https://doi.org/10.1021/es501412n
Autor:
Carmen R. Wood, Crystal L. Johnson, J. Christopher Corton, Michael H. George, Charles E. Wood, Gleta Carswell, Micheal P. Jokinen, Greg R. Olson, Brian N. Chorley, Anthony B. DeAngelo, Julia H. Carter, Virunya S. Bhat, Susan D. Hester
Publikováno v:
Toxicological Sciences. 139:21-34
More efficient models are needed to assess potential carcinogenicity hazard of environmental chemicals based on early events in tumorigenesis. Here, we investigated time course profiles for key events in an established cancer mode of action. Using a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db416e7f722af3b073ca7cd102d90322
https://doi.org/10.1093/toxsci/kfu025
https://doi.org/10.1093/toxsci/kfu025
Publikováno v:
Cancer Research. 78:5049-5049
Dichloroacetic acid (DCA) is a hepatocellular carcinogen in the male B6C3F1 mouse. Histopathologic analysis of a timed DCA dose response study has demonstrated three hepatic lesion sequences in this model. The purpose of the present study of 465 B6C3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b38cb7a3160c7423080317cde6d813d
https://doi.org/10.1158/1538-7445.am2018-5049
https://doi.org/10.1158/1538-7445.am2018-5049
Autor:
William O. Ward, Lynn M. Crosby, Jane Ellen Simmons, Kevin T. Morgan, Anthony B. DeAngelo, Tanya Moore
Publikováno v:
Journal of Toxicology and Environmental Health, Part A. 71:1195-1215
Large-scale differential gene expression analysis was used to examine the biological effects of disinfected surface waters on cultured rat hepatocytes. Source water from East Fork Lake (Harsha Lake), a reservoir on the Little Miami River in Ohio, was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a70f910d87378ca9a5dc238525739873
https://doi.org/10.1080/15287390802182581
https://doi.org/10.1080/15287390802182581
Publikováno v:
Water Science and Technology. 56:51-55
Research was initiated to develop an in vitro system to identify disinfection by-products with a potential to transform normal human colonocytes into malignant cells. Tribromomethane and bromochloroacetic acid, rodent colon carcinogens, dibromonitrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b00bf8feb05eca7dc5d9cb21e1978a46
https://doi.org/10.2166/wst.2007.830
https://doi.org/10.2166/wst.2007.830
Autor:
Tanya Moore, Michael H. George, David R. Geter, William O. Ward, James W. Allen, Bobby Crissman, Adam Swank, Gail M. Nelson, Anthony B. DeAngelo, Don A. Delker, Stephen Kilburn, Barbara C. Roop, Gary E. Hatch, Ralph Slade
Publikováno v:
Toxicology. 221:158-165
Biomarkers of exposure & effect:: validationBiomarker: oxidative stress (gene expression)Exposure/effect represented: potassium bromate (KBrO3)/ DNA damageStudy type (in vitro, animals, humans): male F344 ratsMode of exposure (if in vivo) (acute, chr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90c3cdf58cacf9156e0ee5a53a12f62d
https://doi.org/10.1016/j.tox.2005.12.011
https://doi.org/10.1016/j.tox.2005.12.011
Autor:
Michael H. George, Gloria Huggins-Clark, Steve Kilburn, Anthony B. DeAngelo, Tanya Moore, David R. Geter
Publikováno v:
Journal of Toxicology and Environmental Health, Part A. 67:23-29
Bromodichloromethane (BDCM) and tribromomethane given by corn oil gavage were previously found to induce neoplasia in the large intestine of rats. Our chronic bioassay of BDCM administered in drinking water failed to produce colon neoplasia in male F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::616b97836fd57606b6fe5c2e59d8b6ab
https://doi.org/10.1080/15287390490253642
https://doi.org/10.1080/15287390490253642