Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Anthony B. Cooper"'
Publikováno v:
Antibodies, Vol 12, Iss 3, p 54 (2023)
Therapeutic antibodies represent the most significant modality in biologics, with around 150 approved drugs on the market. In addition to specific target binding mediated by the variable fragments (Fvs) of the heavy and light chains, antibodies posse
Externí odkaz:
https://doaj.org/article/88e7dc5c418f4819ba70208472531bf6
Autor:
Maoyi Lai, Alicia Gonzalez-Martin, Anthony B. Cooper, Hiroyo Oda, Hyun Yong Jin, Jovan Shepherd, Linling He, Jiang Zhu, David Nemazee, Changchun Xiao
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
MicroRNA cluster 17∼92 plays a critical role in B-cell differentiation. Here the authors show that miR-19 regulates B-cell tolerance via suppressing the expression of PTEN, whereas miR- 17 is essential for early B-cell development independently of
Externí odkaz:
https://doaj.org/article/99a9b5cebeca4de094483492341bfcd1
Autor:
Thi-Sau Migone, Zoia Levashova, Sebastian Guelman, Ryan Dorfman, Andrew D. Avery, Anthony B. Cooper, Maryam M. Bhatti, Allen G. Cai, Jan-Willem Theunissen
The primary function of tissue factor (TF) resides in the vasculature as a cofactor of blood clotting; however, multiple solid tumors aberrantly express this transmembrane receptor on the cell surface. Here, we developed anti-TF antibody–drug conju
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a9af9f3eb10a892b4846b80595d9a01
https://doi.org/10.1158/1535-7163.c.6537849.v1
https://doi.org/10.1158/1535-7163.c.6537849.v1
Autor:
Thi-Sau Migone, Zoia Levashova, Sebastian Guelman, Ryan Dorfman, Andrew D. Avery, Anthony B. Cooper, Maryam M. Bhatti, Allen G. Cai, Jan-Willem Theunissen
Supplementary Table S1. Screening Data; Supplementary Table S2. Binding Data; Supplementary Table S3. TGA Data; Supplementary Table S4. ADC Data With Ranking
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69db7bae4996febd810a10a32193713f
https://doi.org/10.1158/1535-7163.22504785
https://doi.org/10.1158/1535-7163.22504785
Autor:
Thi-Sau Migone, Zoia Levashova, Sebastian Guelman, Ryan Dorfman, Andrew D. Avery, Anthony B. Cooper, Maryam M. Bhatti, Allen G. Cai, Jan-Willem Theunissen
Supplementary Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ab831a13a6726f0627401e143473ccb
https://doi.org/10.1158/1535-7163.22504788.v1
https://doi.org/10.1158/1535-7163.22504788.v1
Autor:
Ethan Clark, Gwendolyn M Wilmes, Rachel S Quesenberry, Sergey V Shulga-Morskoy, Violetta Medik, Stuart W. Hicks, Megan E Lewis, Stephen R Lutz, Anthony B Cooper, Hugh H. Russell, Elizabeth E. Reczek, Paulina Kocjan, Jesse A Stevenson, Kimberly L Carey
Publikováno v:
mAbs
Antibody combination therapeutics (ACTs) are polyvalent biopharmaceuticals that are uniquely suited for the control of complex diseases, including antibiotic resistant infectious diseases, autoimmune disorders and cancers. However, ACTs also represen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e21b4b9f26ad2a6a895ed8b21f87f656
Autor:
Anthony B. Cooper, David Nemazee, Katherine Doores, William R. Schief, Khoa Le, Miyo Aoki-Ota, Colleen Doyle-Cooper, Richard T. Wyatt, Takayuki Ota, Dennis R. Burton
Publikováno v:
The Journal of Immunology. 191:3179-3185
Broadly neutralizing Abs against HIV protect from infection, but their routine elicitation by vaccination has not been achieved. To generate small animal models to test vaccine candidates, we have generated targeted transgenic (“knock-in”) mice e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::274a1280c29a4c41cf3b3816aade278c
https://doi.org/10.4049/jimmunol.1301283
https://doi.org/10.4049/jimmunol.1301283
Autor:
Khoa Le, Ralph Pantophlet, Anthony B. Cooper, Michael Huber, Dennis R. Burton, David Nemazee, Chi-Huey Wong, Colleen Doyle-Cooper, Katherine Doores, Sheng-Kai Wang
Publikováno v:
Journal of Virology. 87:2234-2241
The highly conserved cluster of high-mannose glycans on the HIV-1 envelope glycoprotein, gp120, has been highlighted as a target for neutralizing antibodies. 2G12, the first HIV-1 antiglycan neutralizing antibody described, binds with an unusual doma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c286fce78af47a3bd7a255b97d8bfd
https://doi.org/10.1128/jvi.02820-12
https://doi.org/10.1128/jvi.02820-12
Autor:
Anthony B. Cooper, Michael B. Zwick, William R. Schief, David Nemazee, Krystalyn E. Hudson, Patrick Skog, Colleen Doyle-Cooper, Phillip E. Dawson, Takayuki Ota, Dennis R. Burton
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 191(6)
A major goal of HIV research is to develop vaccines reproducibly eliciting broadly neutralizing Abs (bNAbs); however, this has proved to be challenging. One suggested explanation for this difficulty is that epitopes seen by bNAbs mimic self, leading
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5305b1ed70fe19d13aa773853db7591
https://pubmed.ncbi.nlm.nih.gov/23940276
https://pubmed.ncbi.nlm.nih.gov/23940276
Autor:
Pascal Poignard, Khoa Le, David Nemazee, John R. Mascola, Lars Hangartner, Jeffrey D. Lifson, Katherine Doores, James M. Binley, William R. Schief, Anthony B. Cooper, Bimal K. Chakrabarti, Emilia Falkowska, Colleen Doyle-Cooper, Devin Sok, Xueling Wu, Takayuki Ota, Joseph G. Jardine, Michael Huber, Dennis R. Burton, Richard T. Wyatt
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 189(10)
Challenge studies following passive immunization with neutralizing Abs suggest that an HIV vaccine could be efficacious were it able to elicit broadly neutralizing Abs (bNAbs). To better understand the requirements for activation of B cells producing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4da636f4ac854f4a592c7f9c658d0630
https://pubmed.ncbi.nlm.nih.gov/23066156
https://pubmed.ncbi.nlm.nih.gov/23066156