Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Anthony B Firulli"'
Publikováno v:
PLoS Genetics, Vol 13, Iss 7, p e1006922 (2017)
Coordinated cardiomyocyte growth, differentiation, and morphogenesis are essential for heart formation. We demonstrate that the bHLH transcription factors Hand1 and Hand2 play critical regulatory roles for left ventricle (LV) cardiomyocyte proliferat
Externí odkaz:
https://doaj.org/article/f61c97e4181a4256a2650c8546fa46bb
Autor:
Rajendra P. Gajula, Sivarajan T. Chettiar, Russell D. Williams, Katriana Nugent, Yoshinori Kato, Hailun Wang, Reem Malek, Kekoa Taparra, Jessica Cades, Anvesh Annadanam, A-Rum Yoon, Elana Fertig, Beth A. Firulli, Lucia Mazzacurati, Timothy F. Burns, Anthony B. Firulli, Steven S. An, Phuoc T. Tran
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 57, Iss , Pp 101010- (2024)
Externí odkaz:
https://doaj.org/article/b493658f8b604dd9813e1e3c4f3fd4e0
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115871 (2014)
Neuregulin 1 signaling plays an important role in cardiac trabecular development, and in sustaining functional integrity in adult hearts. Treatment with neuregulin 1 enhances adult cardiomyocyte differentiation, survival and/or function in vitro and
Externí odkaz:
https://doaj.org/article/c69ed058fd7c4bc3b1f31fdedd4e58f4
Autor:
Joshua W Vincentz, Beth A Firulli, Andrea Lin, Douglas B Spicer, Marthe J Howard, Anthony B Firulli
Publikováno v:
PLoS Genetics, Vol 9, Iss 3, p e1003405 (2013)
Neural crest cells are multipotent progenitor cells that can generate both ectodermal cell types, such as neurons, and mesodermal cell types, such as smooth muscle. The mechanisms controlling this cell fate choice are not known. The basic Helix-loop-
Externí odkaz:
https://doaj.org/article/84367254c64048cc8abd24df334edc5f
Autor:
Karin D. Prummel, Helena L. Crowell, Susan Nieuwenhuize, Eline C. Brombacher, Stephan Daetwyler, Charlotte Soneson, Jelena Kresoja-Rakic, Agnese Kocere, Manuel Ronner, Alexander Ernst, Zahra Labbaf, David E. Clouthier, Anthony B. Firulli, Héctor Sánchez-Iranzo, Sundar R. Naganathan, Rebecca O’Rourke, Erez Raz, Nadia Mercader, Alexa Burger, Emanuela Felley-Bosco, Jan Huisken, Mark D. Robinson, Christian Mosimann
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
The mesothelium supports homeostasis and regeneration, yet its development origins remain unclear. Here, the authors uncovered the earliest mesothelium progenitor cells in zebrafish, linking Hand2 gene function to mesothelium formation and its re-act
Externí odkaz:
https://doaj.org/article/445f40166b9345a1905f77ae35cd17f3
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 9, Iss 7, p 214 (2022)
The cardiac conduction system, a network of specialized cells, is required for the functioning of the heart. The basic helix loop helix factors Hand1 and Hand2 are required for cardiac morphogenesis and have been implicated in cardiac conduction syst
Externí odkaz:
https://doaj.org/article/a0b120ad458c419cba3bdf6f1cd2b2be
Autor:
Rajani M. George, Anthony B. Firulli
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Epigenetic control of gene expression during cardiac development and disease has been a topic of intense research in recent years. Advances in experimental methods to study DNA accessibility, transcription factor occupancy, and chromatin conformation
Externí odkaz:
https://doaj.org/article/cee338d47774481688dda06388ea32f1
Autor:
Rajani M. George, Anthony B. Firulli
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 8, Iss 5, p 50 (2021)
We have previously identified a Hand1 transcriptional enhancer that drives expression within the septum transversum, the origin of the cells that contribute to the epicardium. This enhancer directly overlaps a common exon of a predicted family of lon
Externí odkaz:
https://doaj.org/article/d9220c8152a645ca8c421224c46dcbd3
Autor:
Rajani M. George, Beth A. Firulli, Ram Podicheti, Douglas B. Rusch, Brandon J. Mannion, Len A. Pennacchio, Marco Osterwalder, Anthony B. Firulli
Publikováno v:
Development. 150
The transcription factor HAND2 plays essential roles during cardiogenesis. Hand2 endocardial deletion (H2CKO) results in tricuspid atresia or double inlet left ventricle with accompanying intraventricular septum defects, hypo-trabeculated ventricles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe585e342bf07de420b1f4a1b8f059cb
https://doi.org/10.1242/dev.201341
https://doi.org/10.1242/dev.201341
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 7, Iss 2, p 13 (2020)
Congenital heart defects (CHDs) occur with such a frequency that they constitute a significant cause of morbidity and mortality in both children and adults. A significant portion of CHDs can be attributed to aberrant development of the cardiac outflo
Externí odkaz:
https://doaj.org/article/82bed867ab64443093963aa07ed6c029