Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Anthony Aimon"'
Autor:
Alice Douangamath, Daren Fearon, Paul Gehrtz, Tobias Krojer, Petra Lukacik, C. David Owen, Efrat Resnick, Claire Strain-Damerell, Anthony Aimon, Péter Ábrányi-Balogh, José Brandão-Neto, Anna Carbery, Gemma Davison, Alexandre Dias, Thomas D. Downes, Louise Dunnett, Michael Fairhead, James D. Firth, S. Paul Jones, Aaron Keeley, György M. Keserü, Hanna F. Klein, Mathew P. Martin, Martin E. M. Noble, Peter O’Brien, Ailsa Powell, Rambabu N. Reddi, Rachael Skyner, Matthew Snee, Michael J. Waring, Conor Wild, Nir London, Frank von Delft, Martin A. Walsh
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
The SARS-CoV-2 main protease is an important target for the development of COVID-19 therapeutics. Here, the authors combine X-ray crystallography and mass spectrometry and performed a large scale fragment screening campaign, which yielded 96 liganded
Externí odkaz:
https://doaj.org/article/d499338758524d99942f9963faf75661
Publikováno v:
Molecules, Vol 24, Iss 14, p 2654 (2019)
A new and direct approach to the construction of the core framework of the herbicidal natural products cornexistin and hydroxycornexistin has been developed. Formation of the nine-membered carbocycle found in the natural products has been accomplishe
Externí odkaz:
https://doaj.org/article/4c95fe338d0140d683bc49518da90480
Autor:
Harold Grosjean, Anthony Aimon, Storm Hassell-Hart, Warren Thompson, Lizbé Koekemoer, James Bennett, Cameron Anderson, Edward A FitzGerald, Tobias Krojer, Anthony Bradley, Oleg Fedorov, Philip C. Biggin, John Spencer, Frank von Delft
We demonstrate that a simple workflow of array synthesis, combining low-cost robotics with analytic techniques to deconvolute crude reaction mixtures, is an effective way to collect structural data on a binding site. Starting from the high informatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4cc69895c8652fe28d23e99f8712f65
https://doi.org/10.26434/chemrxiv-2023-6m2s0
https://doi.org/10.26434/chemrxiv-2023-6m2s0
Autor:
Anthony Aimon, Mark Dow, Abigail Hanby, Ephraim Okolo, Christopher Pask, Adam Nelson, Stephen Marsden
The stereocontrolled synthesis of complex spirotricyclic systems containing an embedded syn-1,2-diaminocyclohexane unit is reported, based upon a dearomatising oxidation of phenols bearing pendant ureas capable of acting as double nucleophiles. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b0093beb437cbd7e3b9dffd99a103c3
https://doi.org/10.26434/chemrxiv-2022-q2r14
https://doi.org/10.26434/chemrxiv-2022-q2r14
Publikováno v:
Chemistry–Methods. 1:192-200
A high-throughput method for the screening of miniature mesoporous metal oxide oxidation catalysts were developed. This was achieved by using multiple robotic techniques including 3D printing. The catalysts (Co3O4, Au/Co3O4, Pd/Co3O4 and Co/Mn mesopo
Autor:
Arathy Jose, Daniel Guest, Remi LeGay, Graham J. Tizzard, Simon J. Coles, Mariliza Derveni, Edward Wright, Lester Marrison, Alpha A. Lee, Aaron Morris, Matt Robinson, Frank von Delft, Daren Fearon, Lizbé Koekemoer, Tetiana Matviuk, Anthony Aimon, Christopher J. Schofield, Tika R. Malla, Nir London, Barnaby W. Greenland, Mark C. Bagley, John Spencer, null The Covid Moonshot Consortium
Publikováno v:
ChemMedChem. 17(7)
The pentafluorosulfanyl (-SF5) functional group is of increasing interest as a bioisostere in medicinal chemistry. A library of SF5-containing compounds, including amide, isoxazole, and oxindole derivatives, was synthesised using a range of solution-
Autor:
Anthony Aimon, John Chodera, David Mobley, Frank Von Delft, Mehtap Işık, Harold Grosjean, Philip Biggin
Publikováno v:
Journal of computer-aided molecular design, vol 36, iss 4
A novel crystallographic fragment screening data set was generated and used in the SAMPL7 challenge for protein-ligands. The SAMPL challenges prospectively assess the predictive power of methods involved in computer-aided drug design. Application of
Autor:
Jitske Jansen, Katharina C. Reimer, James S. Nagai, Finny S. Varghese, Gijs J. Overheul, Marit de Beer, Rona Roverts, Deniz Daviran, Liline A.S. Fermin, Brigith Willemsen, Marcel Beukenboom, Sonja Djudjaj, Saskia von Stillfried, Larissa E. van Eijk, Mirjam Mastik, Marian Bulthuis, Wilfred den Dunnen, Harry van Goor, Jan-Luuk Hillebrands, Sergio H. Triana, Theodore Alexandrov, Marie-Cherelle Timm, Bartholomeus T. van den Berge, Martijn van den Broek, Quincy Nlandu, Joelle Heijnert, Eric M.J. Bindels, Remco M. Hoogenboezem, Fieke Mooren, Christoph Kuppe, Pascal Miesen, Katrien Grünberg, Ties Ijzermans, Eric J. Steenbergen, Jan Czogalla, Michiel F. Schreuder, Nico Sommerdijk, Anat Akiva, Peter Boor, Victor G. Puelles, Jürgen Floege, Tobias B. Huber, Ronald P. van Rij, Ivan G. Costa, Rebekka K. Schneider, Bart Smeets, Rafael Kramann, Hagit Achdout, Anthony Aimon, Elad Bar-David, Haim Barr, Amir Ben-Shmuel, James Bennett, Melissa L. Boby, Bruce Borden, Gregory R. Bowman, Juliane Brun, Sarma BVNBS, Mark Calmiano, Anna Carbery, Emma Cattermole, Eugene Chernychenko, John D. Choder, Austin Clyde, Joseph E. Coffland, Galit Cohen, Jason Cole, Alessandro Contini, Lisa Cox, Milan Cvitkovic, Alex Dias, Kim Donckers, David L. Dotson, Alica Douangamath, Shirly Duberstein, Tim Dudgeon, Louise Dunnett, Peter K. Eastman, Noam Erez, Charles J. Eyermann, Mike Fairhead, Gwen Fate, Daren Fearon, Oleg Federov, Matteo Ferla, Rafaela S. Fernandes, Lori Ferrins, Richard Foster, Holly Foster, Ronen Gabizon, Adolfo Garcia-Sastre, Victor O. Gawriljuk, Paul Gehrtz, Carina Gileadi, Charline Giroud, William G. Glass, Robert Glen, null Itai glinert, Andre S. Godoy, Marian Gorichko, Tyler Gorrie-Stone, Ed J. Griffen, Storm Hassell Hart, Jag Heer, Micheal Henry, Michelle Hill, Sam Horrell, Matthew F.D. Hurley, Tomer Israely, Andrew Jajack, Eric Jnoff, Dirk Jochmans, Tobias John, Steven De Jonghe, Anastassia L. Kantsadi, Peter W. Kenny, J.L. Kiappes, Lizbe Koekemoer, Boris Kovar, Tobias Krojer, Alpha A. Lee, Bruce A. Lefker, Haim Levy, Nir London, Petra Lukacik, Hannah Bruce Macdonald, Beth Maclean, Tika R. Malla, Tatiana Matviiuk, Willam McCorkindale, Briana L. McGovern, Sharon Melamed, Oleg Michurin, Halina Mikolajek, Bruce F. Milne, Aaron Morris, Garret M. Morris, Melody Jane Morwitzer, Demetri Moustakas, Aline M. Nakamura, Jose Brandao Neto, Johan Neyts, Luong Nguyen, Gabriela D. Noske, Vladas Oleinikovas, Glaucius Oliva, David Owen, Vladimir Psenak, Ruby Pai, Jin Pan, Nir Paran, Benjamin Perry, Maneesh Pingle, Jakir Pinjari, Boaz Politi, Ailsa Powell, Reut Puni, Victor L. Rangel, Ranbabu N. Reddi, St Patrick Reid, Efrat Resnick, Emily Grace Ripka, Matthew C. Robinson, Ralph P. Robinson, Jaime Rodriguez-Guerra, Romel Rosales, Dominic Rufa, Chris Schofield, Mikhail Shafeev, Aarif Shaikh, Jiye Shi, Khriesto Shurrush, Sukrit Sing, Assa Sittner, Rachael Skyner, Adam Smalley, Mihaela D. Smilova, Leonardo J. Solmesky, John Spencer, Claire Strain-Damarell, Vishwanath Swamy, Hadas Tamir, Rachael Tennant, Warren Thompson, Andrew Thompson, Susana Tomasia, Anthony Tumber, Ioannis Vakonakis, Laura van Geel, Mariana Vaschetto, Einat B. Vitner, Vincent Voelz, Andra Volkamer, Frank von Delft, Annette von Delft, Martin Walsh, Walter Ward, Charlie Weatherall, Shay Weiss, Kris M. White, Conor Francis Wild, Matthew Wittmann, Nathan Wright, Yfat Yahalom-Ronen, Daniel Zaidmann, Hadeer Zidane, Nicole Zitzmann
Publikováno v:
Cell Stem Cell, 29, 217-231
Cell Stem Cell, 29(2), 217-231.e8. Cell Press
Cell stem cell, 29(2), 217-231.e8. CELL PRESS
Cell Stem Cell, 29, 2, pp. 217-231
Cell Stem Cell
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Cell Stem Cell, 29(2), 217-231.e8. Cell Press
Cell stem cell, 29(2), 217-231.e8. CELL PRESS
Cell Stem Cell, 29, 2, pp. 217-231
Cell Stem Cell
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Kidney failure is frequently observed during and after COVID-19, but it remains elusive whether this is a direct effect of the virus. Here, we report that SARS-CoV-2 directly infects kidney cells and is associated with increased tubule-interstitial k
A high-throughput method for the screening of miniature mesoporous metal oxide oxidation catalysts were developed. This was achieved by using multiple robotic techniques including 3D printing. The catalysts (Co3O4, Au/Co3O4, Pd/Co3O4 and Co/Mn mesopo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f1842b5cc7cf6221cdab4e85e4835e
https://doi.org/10.26434/chemrxiv.12674117
https://doi.org/10.26434/chemrxiv.12674117
Autor:
Alexander N. Plotnikov, Haim Barr, S. Velupillai, T. Krojer, Jingxu Guo, Jinrui Gan, Huib Ovaa, Oleg Fedorov, Christopher G. Dowson, Gian Filippo Ruda, R. Sethi, Chu Wang, Michael Fairhead, Ronen Gabizon, Nava Reznik, Gabriel Amitai, Daniel Zaidman, T. Szommer, James Bennett, Dom Bellini, Nir London, Paul P. Geurink, Efrat Resnick, Anthony Aimon, Verena M. Straub, Anthony R. Bradley, Frank von Delft, Y. Zhang, Alun R. Coker, Alice Douangamath, Laura Diaz Saez, Paul Brennan, Kilian Huber, Jin Gan
Publikováno v:
Journal of the American Chemical Society, 141(22), 8951-8968
Journal of the American Chemical Society, 141(22), 8951-8968. AMER CHEMICAL SOC
Journal of the American Chemical Society, 141(22), 8951-8968. AMER CHEMICAL SOC
[Image: see text] Covalent probes can display unmatched potency, selectivity, and duration of action; however, their discovery is challenging. In principle, fragments that can irreversibly bind their target can overcome the low affinity that limits r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc5c370637dd62cafe589b277a9c578
http://wrap.warwick.ac.uk/119286/1/WRAP-rapid-covalent-probe-discovery-electrophile-fragment-screening-Dowson-2019.pdf
http://wrap.warwick.ac.uk/119286/1/WRAP-rapid-covalent-probe-discovery-electrophile-fragment-screening-Dowson-2019.pdf