Zobrazeno 1 - 10
of 387
pro vyhledávání: '"Anthony A. Hyman"'
Autor:
Mrityunjoy Kar, Laura T. Vogel, Gaurav Chauhan, Suren Felekyan, Hannes Ausserwöger, Timothy J. Welsh, Furqan Dar, Anjana R. Kamath, Tuomas P. J. Knowles, Anthony A. Hyman, Claus A. M. Seidel, Rohit V. Pappu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Phase separation and percolation contribute to phase transitions of multivalent macromolecules. Contributions of percolation are evident through the viscoelasticity of condensates and through the formation of heterogeneous distributions of n
Externí odkaz:
https://doaj.org/article/12c6a6e070804665adbd0503a07d444e
Autor:
William E. Arter, Runzhang Qi, Nadia A. Erkamp, Georg Krainer, Kieran Didi, Timothy J. Welsh, Julia Acker, Jonathan Nixon-Abell, Seema Qamar, Jordina Guillén-Boixet, Titus M. Franzmann, David Kuster, Anthony A. Hyman, Alexander Borodavka, Peter St George-Hyslop, Simon Alberti, Tuomas P. J. Knowles
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
A central concept for characterising phase-separating systems is the phase diagram but generation of such diagrams for biomolecular systems is typically slow and low-throughput. Here the authors describe PhaseScan, a combinatorial droplet microfluidi
Externí odkaz:
https://doaj.org/article/21a365c2a2af4ba08de716204af10bed
Publikováno v:
Natural Sciences, Vol 2, Iss 4, Pp n/a-n/a (2022)
Abstract Preface by Prof. Titia de Lange, Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY 10065, USA The 19th Annual Wiley Prize in Biomedical Sciences celebrated a breakthrough in cell biology: how membrane‐less
Externí odkaz:
https://doaj.org/article/1d4e4a33d3154b5280810bf8f49e0c25
Autor:
Georg Krainer, Timothy J. Welsh, Jerelle A. Joseph, Jorge R. Espinosa, Sina Wittmann, Ella de Csilléry, Akshay Sridhar, Zenon Toprakcioglu, Giedre Gudiškytė, Magdalena A. Czekalska, William E. Arter, Jordina Guillén-Boixet, Titus M. Franzmann, Seema Qamar, Peter St George-Hyslop, Anthony A. Hyman, Rosana Collepardo-Guevara, Simon Alberti, Tuomas P. J. Knowles
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Elucidating the molecular driving forces underlying liquid–liquid phase separation is a key objective for understanding biological function and malfunction. Here the authors show that a wide range of cellular proteins, including FUS, TDP-43, Brd4,
Externí odkaz:
https://doaj.org/article/f1a7c13511ed46d3b7d48b9f4017a81c
Autor:
Sonja Kroschwald, Matthias C. Munder, Shovamayee Maharana, Titus M. Franzmann, Doris Richter, Martine Ruer, Anthony A. Hyman, Simon Alberti
Publikováno v:
Cell Reports, Vol 23, Iss 11, Pp 3327-3339 (2018)
Summary: How cells adapt to varying environmental conditions is largely unknown. Here, we show that, in budding yeast, the RNA-binding and stress granule protein Pub1 has an intrinsic property to form condensates upon starvation or heat stress and th
Externí odkaz:
https://doaj.org/article/45964f1988424c79ad7766f5b68639d6
Autor:
Lara Marrone, Ina Poser, Ian Casci, Julia Japtok, Peter Reinhardt, Antje Janosch, Cordula Andree, Hyun O. Lee, Claudia Moebius, Ellen Koerner, Lydia Reinhardt, Maria Elena Cicardi, Karl Hackmann, Barbara Klink, Angelo Poletti, Simon Alberti, Marc Bickle, Andreas Hermann, Udai Bhan Pandey, Anthony A. Hyman, Jared L. Sterneckert
Publikováno v:
Stem Cell Reports, Vol 10, Iss 2, Pp 375-389 (2018)
Summary: Perturbations in stress granule (SG) dynamics may be at the core of amyotrophic lateral sclerosis (ALS). Since SGs are membraneless compartments, modeling their dynamics in human motor neurons has been challenging, thus hindering the identif
Externí odkaz:
https://doaj.org/article/8c3c165643d94092bf3823929978ee6c
Autor:
Marcel Naumann, Arun Pal, Anand Goswami, Xenia Lojewski, Julia Japtok, Anne Vehlow, Maximilian Naujock, René Günther, Mengmeng Jin, Nancy Stanslowsky, Peter Reinhardt, Jared Sterneckert, Marie Frickenhaus, Francisco Pan-Montojo, Erik Storkebaum, Ina Poser, Axel Freischmidt, Jochen H. Weishaupt, Karlheinz Holzmann, Dirk Troost, Albert C. Ludolph, Tobias M. Boeckers, Stefan Liebau, Susanne Petri, Nils Cordes, Anthony A. Hyman, Florian Wegner, Stephan W. Grill, Joachim Weis, Alexander Storch, Andreas Hermann
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Abnormal cytoplasmic aggregates of FUS are a hallmark of some forms of amyotrophic lateral sclerosis (ALS). Here, using neurons derived from patients with FUS-ALS, the authors demonstrate that impairment of PARP-dependent DNA damage signaling is an e
Externí odkaz:
https://doaj.org/article/421d7fe19126448d9734fe819843c747
Autor:
Yusuke Toyoda, Cedric J. Cattin, Martin P. Stewart, Ina Poser, Mirko Theis, Teymuras V. Kurzchalia, Frank Buchholz, Anthony A. Hyman, Daniel J. Müller
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
During cell division animal cells generate intracellular pressure and round against their environment, but the genes responsible for this are largely unknown. Here the authors use a microcantilever- and RNAi-based assay to screen > 1000 genes and ide
Externí odkaz:
https://doaj.org/article/e90be210e50b44a588340bc826ea3fc6
Autor:
Amayra Hernández-Vega, Marcus Braun, Lara Scharrel, Marcus Jahnel, Susanne Wegmann, Bradley T. Hyman, Simon Alberti, Stefan Diez, Anthony A. Hyman
Publikováno v:
Cell Reports, Vol 20, Iss 10, Pp 2304-2312 (2017)
Non-centrosomal microtubule bundles play important roles in cellular organization and function. Although many diverse proteins are known that can bundle microtubules, biochemical mechanisms by which cells could locally control the nucleation and form
Externí odkaz:
https://doaj.org/article/1ccdb023918c43939db96c6ce43f374e
Publikováno v:
mBio, Vol 9, Iss 5 (2018)
ABSTRACT RNA viruses that replicate in the cell cytoplasm typically concentrate their replication machinery within specialized compartments. This concentration favors enzymatic reactions and shields viral RNA from detection by cytosolic pattern recog
Externí odkaz:
https://doaj.org/article/6513b5d6e98d4908b78ef9dda1bca69e