Zobrazeno 1 - 10
of 287
pro vyhledávání: '"Anthony A. Chalmers"'
Autor:
Sophie A. Twigger, Blanca Dominguez, Vanesa Porto, Lina Hacker, Anthony J. Chalmers, Ross Breckenridge, Martin Treder, Adam C. Sedgwick, Fernando Dominguez, Ester M. Hammond
Publikováno v:
Redox Biology, Vol 76, Iss , Pp 103326- (2024)
Regions of hypoxia occur in most solid tumours and are known to significantly impact therapy response and patient prognosis. Ag5 is a recently reported silver molecular cluster which inhibits both glutathione and thioredoxin signalling therefore limi
Externí odkaz:
https://doaj.org/article/67a59339aad4476cbe985cd7a0f974ef
Autor:
Mathias Tesson, Katrina Stevenson, Saadia A. Karim, Colin Nixon, Anthony J. Chalmers, Owen J. Sansom, Eric O'Neill, Keaton Jones, Jennifer P. Morton
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 3 (2024)
Externí odkaz:
https://doaj.org/article/811eecd6813e422088dd8c4cda49dc78
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 42, Iss , Pp 100658- (2023)
Introduction: Stroke is an established complication in cancer patients, amongst whom brain tumour patients have the highest risk of fatal stroke. Radiotherapy is an important treatment for brain tumours and is associated with increased risk of cerebr
Externí odkaz:
https://doaj.org/article/24063dc025564e0ca4c39905b3b8a577
Publikováno v:
CNS Oncology, Vol 11, Iss 02 (2022)
Glioblastoma (GBM) accounts for over 50% of gliomas and carries the worst prognosis of all solid tumors. Owing to the limited local control afforded by surgery alone, efficacious adjuvant treatments such as radiotherapy (RT) and chemotherapy are fund
Externí odkaz:
https://doaj.org/article/8c0c704c44824298aef0dff3611e30df
Autor:
Donna L. Nile, Colin Rae, David J. Walker, Joe Canning Waddington, Isabel Vincent, Karl Burgess, Mark N. Gaze, Robert J. Mairs, Anthony J. Chalmers
Publikováno v:
Cancer & Metabolism, Vol 9, Iss 1, Pp 1-15 (2021)
Abstract Background Neuroblastoma accounts for 7% of paediatric malignancies but is responsible for 15% of all childhood cancer deaths. Despite rigorous treatment involving chemotherapy, surgery, radiotherapy and immunotherapy, the 5-year overall sur
Externí odkaz:
https://doaj.org/article/18c074a3dffa4f188c780def00713faa
Autor:
Gerard M. Walls, Jamie B. Oughton, Anthony J. Chalmers, Sarah Brown, Fiona Collinson, Martin D. Forster, Kevin N. Franks, Alexandra Gilbert, Gerard G. Hanna, Nicola Hannaway, Stephen Harrow, Tom Haswell, Crispin T. Hiley, Samantha Hinsley, Matthew Krebs, Geraldine Murden, Rachel Phillip, Anderson J. Ryan, Ahmed Salem, David Sebag-Montefoire, Paul Shaw, Chris J. Twelves, Katrina Walker, Robin J. Young, Corinne Faivre-Finn, Alastair Greystoke
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 25, Iss , Pp 61-66 (2020)
Lung cancer is the leading cause of cancer mortality worldwide and most patients are unsuitable for ‘gold standard’ treatment, which is concurrent chemoradiotherapy. CONCORDE is a platform study seeking to establish the toxicity profiles of multi
Externí odkaz:
https://doaj.org/article/18ea8996e30244118c8f0fb5dfce7ad3
Publikováno v:
Advances in Radiation Oncology, Vol 5, Iss 5, Pp 994-1005 (2020)
Prostate cancers, like many other types of cancer, express elevated levels of fatty acid synthase (FASN) to make more fatty acids, which are required for energy, signaling, and proliferation. Because inhibition of FASN has been shown to sensitize tum
Externí odkaz:
https://doaj.org/article/9a743a776369410ba57c8fe7ae980be8
Autor:
Robert Rulach, FRCR, David Ball, MD, Kevin L.M. Chua, FRCR, Max Dahele, MBChB, PhD, Dirk De Ruysscher, PhD, Kevin Franks, FRCR, Daniel Gomez, MD, Matthias Guckenberger, MD, Gerard G. Hanna, PhD, Alexander V. Louie, MD, PhD, Drew Moghanaki, MD, MPH, David A. Palma, MD, PhD, Clive Peedell, FRCR, Ahmed Salem, PhD, Shankar Siva, PhD, Gregory M.M. Videtic, MDCM, FRCPC, FACR, FASTRO, Anthony J. Chalmers, PhD, Stephen Harrow, PhD
Publikováno v:
Advances in Radiation Oncology, Vol 6, Iss 2, Pp 100653- (2021)
Purpose: Thoracic reirradiation for non-small cell lung cancer with curative intent is potentially associated with severe toxicity. There are limited prospective data on the best method to deliver this treatment. We sought to develop expert consensus
Externí odkaz:
https://doaj.org/article/8cf5918332a84759847d320c465b5b34
Autor:
Ming Yao Chong, Cressida F Lorimer, Shaveta Mehta, Ehab Ibrahim, Juliet Brock, Catherine McBain, Philip McLoone, Anthony J Chalmers
Publikováno v:
CNS Oncology, Vol 8, Iss 4 (2019)
Aim: We investigated uptake of short-course chemo-radiotherapy and compared outcomes with other treatment schedules in elderly patients with glioblastoma (GBM). Methods: Patients aged 65 or over with a diagnosis of GBM were identified from an 18-mont
Externí odkaz:
https://doaj.org/article/17e9cf2a67f844c0b1a2c73ae975f161
Autor:
Ben Fulton, Susan C. Short, Allan James, Stefan Nowicki, Catherine McBain, Sarah Jefferies, Caroline Kelly, Jon Stobo, Anna Morris, Aoife Williamson, Anthony J. Chalmers
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 8, Iss C, Pp 12-16 (2018)
Glioblastoma has a dismal prognosis and molecular targeted agents have failed to improve outcomes to date. PARADIGM-2 is a phase I dose escalation study evaluating olaparib plus radiotherapy ± temozolomide in newly diagnosed glioblastoma, using MGMT
Externí odkaz:
https://doaj.org/article/69f6ccf5e2064209ba6e1bb4069d7193