Zobrazeno 1 - 10
of 352
pro vyhledávání: '"Anthony A, Holder"'
Autor:
Mohammad Zeeshan, Edward Rea, Steven Abel, Kruno Vukušić, Robert Markus, Declan Brady, Antonius Eze, Ravish Rashpa, Aurelia C. Balestra, Andrew R. Bottrill, Mathieu Brochet, David S. Guttery, Iva M. Tolić, Anthony A. Holder, Karine G. Le Roch, Eelco C. Tromer, Rita Tewari
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract The Aurora family of kinases orchestrates chromosome segregation and cytokinesis during cell division, with precise spatiotemporal regulation of its catalytic activities by distinct protein scaffolds. Plasmodium spp., the causative agents of
Externí odkaz:
https://doaj.org/article/b48dddf02dd94fbda52d44cd32baa0e1
Autor:
Tanyaluck Kampoun, Somdet Srichairatanakool, Parichat Prommana, Philip J. Shaw, Judith L. Green, Ellen Knuepfer, Anthony A. Holder, Chairat Uthaipibull
Publikováno v:
Malaria Journal, Vol 21, Iss 1, Pp 1-10 (2022)
Abstract Background The resistance of Plasmodium falciparum to artemisinin-based (ART) drugs, the front-line drug family used in artemisinin-based combination therapy (ACT) for treatment of malaria, is of great concern. Mutations in the kelch13 (k13)
Externí odkaz:
https://doaj.org/article/3196b35f1366420a955e8f0b0687d746
Autor:
Supawadee Maneekesorn, Ellen Knuepfer, Judith L. Green, Parichat Prommana, Chairat Uthaipibull, Somdet Srichairatanakool, Anthony A. Holder
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract The inducible Di-Cre system was used to delete the putative ubiquitin-conjugating enzyme 13 gene (ubc13) of Plasmodium falciparum to study its role in ubiquitylation and the functional consequence during the parasite asexual blood stage. Del
Externí odkaz:
https://doaj.org/article/056390903119464d8e684ecde45b5954
Autor:
Vanndita Bahl, Kritika Chaddha, Syed Yusuf Mian, Anthony A. Holder, Ellen Knuepfer, Deepak Gaur
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Plasmodium falciparum, the parasite responsible for severe malaria, develops within erythrocytes. Merozoite invasion and subsequent egress of intraerythrocytic parasites are essential for this erythrocytic cycle, parasite survival and pathog
Externí odkaz:
https://doaj.org/article/f65dafb8736d4e99a8c5c3989531a5ab
Autor:
Mohammad Zeeshan, Rajan Pandey, Amit Kumar Subudhi, David J. P. Ferguson, Gursimran Kaur, Ravish Rashpa, Raushan Nugmanova, Declan Brady, Andrew R. Bottrill, Sue Vaughan, Mathieu Brochet, Mathieu Bollen, Arnab Pain, Anthony A. Holder, David S. Guttery, Rita Tewari
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Zeeshan et al. used real-time live-cell and ultrastructural imaging, conditional gene knockdown, RNA-seq and proteomic approaches to implicate Plasmodium PP1 in both mitotic exit and, potentially, establishing cell polarity during zygote development
Externí odkaz:
https://doaj.org/article/b7773fc630264f8886ca813289e58978
Autor:
Mohammad Zeeshan, Ravish Rashpa, David J P Ferguson, Steven Abel, Zeinab Chahine, Declan Brady, Sue Vaughan, Carolyn A Moores, Karine G Le Roch, Mathieu Brochet, Anthony A Holder, Rita Tewari
Publikováno v:
PLoS Biology, Vol 20, Iss 7, p e3001704 (2022)
Kinesins are microtubule (MT)-based motors important in cell division, motility, polarity, and intracellular transport in many eukaryotes. However, they are poorly studied in the divergent eukaryotic pathogens Plasmodium spp., the causative agents of
Externí odkaz:
https://doaj.org/article/c59ab74510044eb5b8416d04d84d4899
Autor:
Samuel Eneọjọ Abah, Florence Burté, Steven A. Howell, Ikeoluwa Lagunju, Wuraola A. Shokunbi, Mats Wahlgren, Olugbemiro Sodeinde, Biobele J. Brown, Anthony A. Holder, Delmiro Fernandez-Reyes
Publikováno v:
Malaria Journal, Vol 19, Iss 1, Pp 1-11 (2020)
Abstract Background Cerebral malaria (CM), is a life-threatening childhood malaria syndrome with high mortality. CM is associated with impaired consciousness and neurological damage. It is not fully understood, as yet, why some children develop CM. P
Externí odkaz:
https://doaj.org/article/02dff663acb44c5ebabf52fa07cf1cab
Autor:
Anja C. Schlott, Ellen Knuepfer, Judith L. Green, Philip Hobson, Aaron J. Borg, Julia Morales-Sanfrutos, Abigail J. Perrin, Catherine Maclachlan, Lucy M. Collinson, Ambrosius P. Snijders, Edward W. Tate, Anthony A. Holder
Publikováno v:
PLoS Biology, Vol 19, Iss 10 (2021)
We have combined chemical biology and genetic modification approaches to investigate the importance of protein myristoylation in the human malaria parasite, Plasmodium falciparum. Parasite treatment during schizogony in the last 10 to 15 hours of the
Externí odkaz:
https://doaj.org/article/5fbf8e9a9f734a64b495f33819b59ac8
Autor:
Edwin Lasonder, Kunal More, Shailja Singh, Malak Haidar, Daniela Bertinetti, Eileen J. Kennedy, Friedrich W. Herberg, Anthony A. Holder, Gordon Langsley, Chetan E. Chitnis
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
We review the role of signaling pathways in regulation of the key processes of merozoite egress and red blood cell invasion by Plasmodium falciparum and, in particular, the importance of the second messengers, cAMP and Ca2+, and cyclic nucleotide dep
Externí odkaz:
https://doaj.org/article/de12574100264a50a9905dfa1595a22b
Autor:
Mohammad Zeeshan, Declan Brady, Rebecca R. Stanway, Carolyn A. Moores, Anthony A. Holder, Rita Tewari
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Kinesin-5 motors play essential roles in spindle apparatus assembly during cell division, by generating forces to establish and maintain the spindle bipolarity essential for proper chromosome segregation. Kinesin-5 is largely conserved structurally a
Externí odkaz:
https://doaj.org/article/f8ae63aa974842f2890b81a2a9a20cf0