Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Anthony R. Haight"'
Autor:
Thaddeus S. Franczyk, Lawrence Kolaczkowski, James C. Marek, Donna K. Montavon, Maureen A. McLaughlin, Guangxin Liang, Anthony R. Haight, Vincent S. Chan, Travis B. Dunn, John E. Hengeveld, David M. Barnes, Jufang Barkalow, Shashank Shekhar, Brian J. Kotecki, James J. Napier
Publikováno v:
The Journal of Organic Chemistry. 84:4873-4892
Dasabuvir (1) is an HCV polymerase inhibitor which has been developed as a part of a three-component direct-acting antiviral combination therapy. During the course of the development of the synthetic route, two novel coupling reactions were developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4480abb41d78d62bf0806f7dbbc334b
https://doi.org/10.1021/acs.joc.8b02690
https://doi.org/10.1021/acs.joc.8b02690
Autor:
Anthony R. Haight, Tony Cano, Brittney J. Mills, Vikram Sisodiya, Feroz Jameel, Ehab M. Moussa
Publikováno v:
Development of Biopharmaceutical Drug-Device Products ISBN: 9783030314149
Antibody-drug conjugates (ADCs) have emerged as a new class of anti-cancer drugs where the strengths of cytotoxic small molecules are combined with specificity/selectivity of antibodies to enhance the therapeutic efficacy and safety of the drug. All
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bd2d164ae8f701c19cc3450f80c8eb2
https://doi.org/10.1007/978-3-030-31415-6_2
https://doi.org/10.1007/978-3-030-31415-6_2
Autor:
John F. Traverse, Thomas Raglione, Anthony R. Haight, Scott A. Miller, Brad D. Maxwell, Klaas Schildknegt, Charles S. Elmore, Boris A. Czeskis, Peng Wang, David Hesk
Publikováno v:
Journal of labelled compoundsradiopharmaceuticalsREFERENCES. 62(11)
The International Consortium for Innovation & Quality (IQ) in Pharmaceutical Development recently established a working group focused on the development of a guidance to address Deuterated Active Pharmaceutical Ingredients. Deuteration of an Active P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb54baf3135e4fe03262566dd994a43
https://pubmed.ncbi.nlm.nih.gov/31034626
https://pubmed.ncbi.nlm.nih.gov/31034626
Autor:
Wayne A. Pritts, Anthony R. Haight, Lawrence Kolaczkowski, Jufang Barkalow, David M. Barnes, Adam Schellinger
Publikováno v:
The Journal of organic chemistry. 84(8)
( R)-Boc-2-methylproline (3a) was synthesized in good yield with excellent stereochemical control from alanine benzyl ester hydrochloride 11. The process, which is based on a modification of one described by Kawabata, proceeds in four steps and requi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7305fef7ed348f47cdfb2e8099679977
https://pubmed.ncbi.nlm.nih.gov/30716275
https://pubmed.ncbi.nlm.nih.gov/30716275
Practical Large-Scale Synthesis of 6-Bromo-2-naphthylmethanesulfonamide Using Semmler–Wolff Reaction
Publikováno v:
Organic Process Research & Development. 18:1696-1701
A practical, scalable synthetic process for a sulfonamide was developed featuring a Semmler–Wolff aromatization as the key step. The optimized reaction conditions using HCl in HOAc give directly the desired naphthylamine in high yield as opposed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::864e2de4fd9a57460121b670a96c2242
https://doi.org/10.1021/op500247h
https://doi.org/10.1021/op500247h
Autor:
Michael J. Rozema, Brian J. Kotecki, Albert W. Kruger, Anthony R. Haight, Albert M. Schwartz, Zhe Wang, Steven M. Richter, Alexander Chu-Kung, Jorge Gandarilla
Publikováno v:
Organic Process Research & Development. 13:1419-1425
The discovery, development and implementation of two chemical routes to ABT-869 is reported. Optimization of the first-generation heterocycle formation and Suzuki coupling is briefly described. Key features of the second-generation synthesis include
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57f6ae83938bfbd467ec2ae87efdc004
https://doi.org/10.1021/op900208y
https://doi.org/10.1021/op900208y
Autor:
David M. Barnes, Jufang Barkalow, Yong Chen, Francis A. J. Kerdesky, John E. Hengeveld, Anthony R. Haight, Bryan Macri, Ashok K. Gupta, Agnes Pal, Brian J. Kotecki
Publikováno v:
Organic Process Research & Development. 13:225-229
The impact of entropic effects on the classical salt resolution of a 2-arylpyrrolidine is described. We have found that the crystallization of a racemic mixture of the base with tartaric acid led to a salt in which the undesired enantiomer is incorpo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cb0d59362c48dc4c483d2151dc2b518
https://doi.org/10.1021/op800242y
https://doi.org/10.1021/op800242y
Autor:
Maureen A. McLaughlin, Joan Dalla Riva Toma, Jianzhang Mei, Thomas Hameury, Jason S. Tedrow, Anthony R. Haight, David M. Barnes
Publikováno v:
Tetrahedron. 62:11311-11319
Novel conditions have been developed for the preparation of substituted 2-aminothiophenes employing the Knoevenagel condensation followed by the Gewald reaction. The benefits of these conditions are their mildness, and the ease of product isolation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::422a96ef4c126567293b97cc94f16cb1
https://doi.org/10.1016/j.tet.2006.07.008
https://doi.org/10.1016/j.tet.2006.07.008
Autor:
Kurt B. Pearl, Elaine C. Lee, Larry Morin, Nancy J. Benz, Rodger F. Henry, Margaret C. Hsu, Sema Z. Ariman, Francoix X. Gueffier, David M. Barnes, Daniel J. Plata, Anthony R. Haight, Matthew J. Peterson, David R. Willcox
Publikováno v:
Organic Process Research & Development. 10:751-756
ABT-492 has been under development at Abbott Laboratories as a quinolone antibiotic. A convergent syntheses was utilized to prepare the compound on a multi-kilogram scale. Difficulties in isolation of intermediates were overcome by developing control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::404d999795957e10ed3e697c25d5bac5
https://doi.org/10.1021/op060054e
https://doi.org/10.1021/op060054e
Autor:
Elaine C. Lee, Eric J. Stoner, Matthew J. Peterson, Jason S. Tedrow, Alan Christesen, Anthony R. Haight, Prasad S. Raje, Seble H. Wagaw, Margaret C. Hsu, Kenneth M. Engstrom, David M. Barnes, Daniel J. Plata
Publikováno v:
Organic Process Research & Development. 10:803-807
The total synthesis of quinolone antibiotic ABT-492 has been achieved in 67% yield over nine steps from 2,4,5-trifluorobenzoic acid. The highlights of this synthesis include a novel chemoselective chlorination at the 8-position of a highly elaborated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0b53de99a4bd49e9b48f64647ed7af4
https://doi.org/10.1021/op0600557
https://doi.org/10.1021/op0600557