3D bioprinted breast cancer model reveals stroma-mediated modulation of extracellular matrix and radiosensitivity

Autor: Theo Desigaux, Leo Comperat, Nathalie Dusserre, Marie-Laure Stachowicz, Malou Lea, Jean-William Dupuy, Anthony Vial, Michael Molinari, Jean-Christophe Fricain, François Paris, Hugo Oliveira

Publikováno v: Bioactive Materials, Vol 42, Iss , Pp 316-327 (2024)

Deciphering breast cancer treatment resistance remains hindered by the lack of models that can successfully capture the four-dimensional dynamics of the tumor microenvironment. Here, we show that microextrusion bioprinting can reproducibly generate d

Externí odkaz: https://doaj.org/article/b7d643e9eb374581aa8eb6438ce2e576

Structures of the archaerhodopsin-3 transporter reveal that disordering of internal water networks underpins receptor sensitization

Autor: Juan F. Bada Juarez, Peter J. Judge, Suliman Adam, Danny Axford, Javier Vinals, James Birch, Tristan O. C. Kwan, Kin Kuan Hoi, Hsin-Yung Yen, Anthony Vial, Pierre-Emmanuel Milhiet, Carol V. Robinson, Igor Schapiro, Isabel Moraes, Anthony Watts

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)

Archaerhodopsin-3 (AR3) mutants are commonly used in optogenetics for neuron silencing and membrane voltage sensing. High-resolution crystal structures show that desensitization of the AR3 photoreceptor occurs when internal hydrogen-bonded water netw

Externí odkaz: https://doaj.org/article/039fb047d8d74a55a61854b573e871d6

Structure and mechanics of the human Nuclear Pore Complex basket

Autor: Anthony Vial, Luca Costa, Patrice Dosset, Pietro Rosso, Gaëlle Boutières, Orestis Faklaris, Heiko Haschke, Pierre-Emmanuel Milhiet, Christine M. Doucet

Nuclear pore complexes (NPCs) are the only gateways between the nucleus and cytoplasm in eukaryotic cells. They restrict free diffusion to molecules below 5 nm while facilitating the active transport of selected cargoes, sometimes as large as the por

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd187d42d1df21ba141e94538fe6424
https://hal.science/hal-03871502/document

Withdrawal notice to 'Aptamer-based nanotrains and nanoflowers as quinine delivery systems' [Int. J. Pharm. 632 (2023) 122552]

Autor: Mengyuan Cao, Anthony Vial, Laetitia Minder, Aurore Guédin, Sébastien Fribourg, Laurent Azéma, Cécile Feuillie, Michael Molinari, Carmelo Di Primo, Philippe Barthélémy, Jeanne Leblond Chain

Publikováno v: International Journal of Pharmaceutics. 632:122734

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1c977526aeba92846b7aa4608067ef6d
https://doi.org/10.1016/j.ijpharm.2023.122734

Structures of the archaerhodopsin-3 transporter reveal that disordering of internal water networks underpins receptor sensitization

Autor: Carol V. Robinson, Hsin-Yung Yen, Juan F. Bada Juarez, Kin Kuan Hoi, Igor Schapiro, Danny Axford, Anthony Vial, Anthony Watts, Isabel Moraes, Suliman Adam, James M. Birch, J. Vinals, Tristan O. C. Kwan, Pierre-Emmanuel Milhiet, Peter J. Judge

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-020-20596-0⟩
Nature Communications, 2021, 12 (1), ⟨10.1038/s41467-020-20596-0⟩
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)

Many transmembrane receptors have a desensitized state, in which they are unable to respond to external stimuli. The family of microbial rhodopsin proteins includes one such group of receptors, whose inactive or dark-adapted (DA) state is established

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9000a783000beccb3e3bcfe84a11468c
https://hal.archives-ouvertes.fr/hal-03415302