Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Anthi, Mettou"'
Autor:
Anna Maranti, George Kontopidis, Christos Papaneophytou, Anthi Mettou, Antreas Afantitis, Polyxeni Alexiou, Elias Eliopoulos, Elias A. Couladouros, Fotini Liepouri, Georgia Melagraki, Athanasios Papakyriakou
Publikováno v:
SLAS Discovery. 23:84-93
The aim of this study is to improve the aqueous solubility of a group of compounds without interfering with their bioassay as well as to create a relevant prediction model. A series of 55 potential small-molecule inhibitors of tumor necrosis factor-a
Autor:
Fotini Liepouri, Christos Papaneophytou, Anna Maranti, Polyxeni Alexiou, Elias A. Couladouros, Anthi Mettou, Eleni Douni, Evangelos Ntougkos, George Kontopidis, Elias Eliopoulos, Alexandros T. Strongilos, George Kollias, Athanasios Papakyriakou, Katerina Tsiliouka
Publikováno v:
MedChemComm. 6:1196-1209
Inhibition of tumor necrosis factor (TNF) production or function by small molecules has become a major focus in the pharmaceutical industry for the treatment of rheumatoid arthritis. In this study, a series of 39 novel SPD-304 analogs were designed,
Autor:
Fotini Liepouri, Katerina Tsiliouka, George Kontopidis, Sotiria Chaitidou, Elias Eliopoulos, Eleni Douni, Alexandros T. Strongilos, Ioannis A. Katsoulis, Anthi Mettou, Elias A. Couladouros, Polyxeni Alexiou, Evangelos Ntougkos, Athanasios Papakyriakou, Christos Papaneophytou, Anna Maranti, George Kollias
Publikováno v:
Archiv der Pharmazie. 347:798-805
SPD-304 was discovered as a promising tumor necrosis factor alpha (TNF) antagonist that promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. However, SPD-304 contains a potentially toxic 3-alkylindole moi
Publikováno v:
ACS Medicinal Chemistry Letters. 4:137-141
Many active compounds may be excluded from biological assays due to their low aqueous solubility. In this study, a simple method for the determination of the solubility of compounds containing aromatic rings is proposed. In addition to DMSO, five org
Autor:
Polyxeni, Alexiou, Athanasios, Papakyriakou, Evangelos, Ntougkos, Christos P, Papaneophytou, Fotini, Liepouri, Anthi, Mettou, Ioannis, Katsoulis, Anna, Maranti, Katerina, Tsiliouka, Alexandros, Strongilos, Sotiria, Chaitidou, Eleni, Douni, George, Kontopidis, George, Kollias, Elias, Couladouros, Elias, Eliopoulos
Publikováno v:
Archiv der Pharmazie. 347(11)
SPD-304 was discovered as a promising tumor necrosis factor alpha (TNF) antagonist that promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. However, SPD-304 contains a potentially toxic 3-alkylindole moi
Publikováno v:
MedChemComm; Jun2015, Vol. 6 Issue 6, p983-990, 8p
Synthesis and biological evaluation of potential small molecule inhibitors of tumor necrosis factor.
Autor:
Papaneophytou, Christos, Alexiou, Polyxeni, Papakyriakou, Athanasios, Ntougkos, Evangelos, Tsiliouka, Katerina, Maranti, Anna, Liepouri, Fotini, Strongilos, Alexandros, Mettou, Anthi, Couladouros, Elias, Eliopoulos, Elias, Douni, Eleni, Kollias, George, Kontopidis, George
Publikováno v:
MedChemComm; Jun2015, Vol. 6 Issue 6, p1196-1209, 14p