Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Anthea Hardcastle"'
Autor:
Paul Workman, Martin Drysdale, Sue Eccles, Florence Raynaud, Edward McDonald, Keith Jones, Laurence Pearl, Wynne Aherne, Roderick E. Hubbard, Nicolas Foloppe, Allan Surgenor, Lisa Wright, Julie E. Cansfield, Xavier Barril, Paul A. Brough, Brian Dymock, Anthea Hardcastle, Angela Hayes, Karen James, Andrew Kalusa, Kwai-Ming J. Cheung, Thomas P. Matthews, Gary Box, Joanna L. Holmes, Marissa V. Powers, Kathy Boxall, Chrisostomos Prodromou, Swee Y. Sharp
Adobe PDF - MCT-07-0149--Suppl_Data.pdf from Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d4d7fb2338ed0110488ee5feca6169d
https://doi.org/10.1158/1535-7163.22485900
https://doi.org/10.1158/1535-7163.22485900
Autor:
Paul Workman, Martin Drysdale, Sue Eccles, Florence Raynaud, Edward McDonald, Keith Jones, Laurence Pearl, Wynne Aherne, Roderick E. Hubbard, Nicolas Foloppe, Allan Surgenor, Lisa Wright, Julie E. Cansfield, Xavier Barril, Paul A. Brough, Brian Dymock, Anthea Hardcastle, Angela Hayes, Karen James, Andrew Kalusa, Kwai-Ming J. Cheung, Thomas P. Matthews, Gary Box, Joanna L. Holmes, Marissa V. Powers, Kathy Boxall, Chrisostomos Prodromou, Swee Y. Sharp
Although the heat shock protein 90 (HSP90) inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) shows clinical promise, potential limitations encourage development of alternative chemotypes. We discovered the 3,4-diarylpyrazole resorcinol CCT018
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::073e5066d6b9dde949d7a67d06d663c3
https://doi.org/10.1158/1535-7163.c.6532131
https://doi.org/10.1158/1535-7163.c.6532131
Autor:
Ian Judson, Paul Workman, Florence Raynaud, Johan S. de Bono, Wynne Aherne, Heidi Peachey, Belle Roels, Udai Banerji, Javier Moreno-Farre, Hendrik-Tobias Arkenau, Anna Zetterlund, Anthea Hardcastle, Martin M. Eatock, Mike Walton, Richard H. Wilson, Simon Pacey
Purpose: A phase I study to define toxicity and recommend a phase II dose of the HSP90 inhibitor alvespimycin (17-DMAG; 17-dimethylaminoethylamino-17-demethoxygeldanamycin). Secondary endpoints included evaluation of pharmacokinetic profile, tumor re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::065bf75e34bed031da5b5cfa70f7d2ce
https://doi.org/10.1158/1078-0432.c.6519198
https://doi.org/10.1158/1078-0432.c.6519198
Autor:
Ian Judson, Paul Workman, Florence Raynaud, Johan S. de Bono, Wynne Aherne, Heidi Peachey, Belle Roels, Udai Banerji, Javier Moreno-Farre, Hendrik-Tobias Arkenau, Anna Zetterlund, Anthea Hardcastle, Martin M. Eatock, Mike Walton, Richard H. Wilson, Simon Pacey
Supplementary Figures S1-S2; Supplementary Tables S1-S2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a2b6f264ee19ebbc60417dae5494792
https://doi.org/10.1158/1078-0432.22442481.v1
https://doi.org/10.1158/1078-0432.22442481.v1
Autor:
Anthea Hardcastle, Rob L. M. van Montfort, Ian Collins, P. Craig McAndrew, Yvette Newbatt, Amin Mirza, Faith E. Davies, Jade Strover, Gareth J. Morgan, Rosemary Burke
Publikováno v:
SLAS Discovery. 18:298-308
Inositol-requiring enzyme 1 alpha (IRE1α) is a transmembrane sensor protein with both kinase and ribonuclease activity, which plays a crucial role in the unfolded protein response (UPR). Protein misfolding in the endoplasmic reticulum (ER) lumen tri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f6c6d393c9566956789b5b69fc92fea
https://doi.org/10.1177/1087057112465647
https://doi.org/10.1177/1087057112465647
Autor:
Martin Eatock, Hendrik-Tobias Arkenau, Richard H. Wilson, Udai Banerji, Javier Moreno-Farre, Paul Workman, Florence I. Raynaud, Simon Pacey, Michael I. Walton, Johann S. de Bono, Anthea Hardcastle, Ian Judson, Heidi Peachey, Anna Zetterlund, Wynne Aherne, Belle Roels
Publikováno v:
Clinical Cancer Research. 17:1561-1570
Purpose: A phase I study to define toxicity and recommend a phase II dose of the HSP90 inhibitor alvespimycin (17-DMAG; 17-dimethylaminoethylamino-17-demethoxygeldanamycin). Secondary endpoints included evaluation of pharmacokinetic profile, tumor re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efc79cec101cdfb38710b18a9355de60
https://doi.org/10.1158/1078-0432.ccr-10-1927
https://doi.org/10.1158/1078-0432.ccr-10-1927
Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response
Autor:
Emma L. Davenport, Anthea Hardcastle, Tina Bagratuni, Laurence H. Pearl, Ian Collins, Gareth J. Morgan, Craig McAndrews, Martin G. Rowlands, M. Cris Silva-Santisteban, Maruf M.U. Ali, Piotr Nowak, G. Wynne Aherne, Faith E. Davies
Publikováno v:
The EMBO Journal. 30:894-905
Ire1 (Ern1) is an unusual transmembrane protein kinase essential for the endoplasmic reticulum (ER) unfolded protein response (UPR). Activation of Ire1 by association of its N-terminal ER luminal domains promotes autophosphorylation by its cytoplasmi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f065061a364c5fe67e2cea1cd01228c
https://doi.org/10.1038/emboj.2011.18
https://doi.org/10.1038/emboj.2011.18
Autor:
Martin G. Rowlands, David Festus Charles Moffat, Lindsay Stimson, Vanessa L. Clark, Lindsey Ann Needham, Francesca Ann Day, Anthea Hardcastle, Judata Wibata, Sue Eccles, Deborah McNamara, Sanjay Patel, A. Donald, Wynne Aherne, Florence I. Raynaud
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6657-6660
Inhibition of histone deacetylase activity represents a promising new modality in the treatment of a number of cancers. A novel HDAC series demonstrating inhibitory activity in cell proliferation assays is described. Optimisation based on the introdu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39718494ed048094fc341c760146382e
https://doi.org/10.1016/j.bmcl.2010.09.016
https://doi.org/10.1016/j.bmcl.2010.09.016
Autor:
Anwar R. Padhani, Michelle Scurr, Anthea Hardcastle, Paul Workman, S Phillips, Wynne Aherne, A J Kakkar, Martin O. Leach, Florence I. Raynaud, J M Trigo, Carmel Hayes, A. Hannah, A. O'Donnell, Ian Judson
Publikováno v:
British Journal of Cancer
SU5416 (Z-3-[(2,4-dimethylpyrrol-5-yl)methylidenyl]-2-indolinone; semaxanib) is a small molecule inhibitor of the vascular endothelial growth factor receptor (VEGFR)2. A Phase I dose escalation study was performed. Dynamic contrast-enhanced magnetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5aa0fb74cdeef28b7dd7dc37c148367
http://europepmc.org/articles/PMC2361651
http://europepmc.org/articles/PMC2361651
Autor:
Florence I. Raynaud, S Bate, Laura Simmons, Ruth Ruddle, Wynne Aherne, Martin Gore, Lynda Pyle, T Benepal, Anthea Hardcastle, Fraser Mitchell, Ann L. Jackman
Publikováno v:
British Journal of Cancer
BGC9331 is a rationally designed, specific nonpolyglutamatable thymidylate synthase (TS) inhibitor that is active in gynaecological malignancies. In the light of the sensitivity of human ovarian tumour cell lines to BGC9331 and non-cross resistance t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5eb5330d281b6340d1f67ea96c30a0a
https://doi.org/10.1038/sj.bjc.6602811
https://doi.org/10.1038/sj.bjc.6602811