Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Antal Orosz"'
Autor:
Rudolf A. Manz, Stefan Tukaj, Detlef Zillikens, Andreia de Castro Marques, Ralf Ludwig, Antal Orosz, Benjamin Tiburzy, Michael Kasperkiewicz
Publikováno v:
Experimental Dermatology. 23:585-590
Heat shock protein 90 (Hsp90) inhibition blocks T-cell-linked inflammatory disease pathways and exhibits therapeutic activity in autoimmune disease mouse models, including the blistering disease epidermolysis bullosa acquisita. Although we previously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c09486c26ad3ae793a6c1d1496015c5
https://doi.org/10.1111/exd.12476
https://doi.org/10.1111/exd.12476
Publikováno v:
Biopolymers. 78:35-45
In this study we compared the steric structures of the bioactive part of substance P (SP[6–11]) and its analogs (NY3460 and pHOPA-SP5). The molecular dynamics–simulated annealing method was used to explore the conformational space, and the struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52e46a4664ab6f7ba8ee7302b6e9ff15
https://doi.org/10.1002/bip.20237
https://doi.org/10.1002/bip.20237
Autor:
Gregory P. Kalemkerian, Muhammad Ali, Antal Orosz, James F. Eliason, Rita Rosati, Mohammed R. Adil, Ferenc Sebestyén
Publikováno v:
Peptides. 19:1519-1523
Small cell lung cancer (SCLC) cells express a variety of neuropeptides which act as autocrine growth factors. Although several neuropeptide analogs have been reported to antagonize SCLC proliferation, the development of these compounds has been limit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e60e761ec2f39e193dc575d13fe8f15
https://doi.org/10.1016/s0196-9781(98)00116-8
https://doi.org/10.1016/s0196-9781(98)00116-8
Publikováno v:
International Journal of Cancer. 60:82-87
Human small-cell lung-cancer cells (SCLC) produce and secrete gastrin-releasing peptide (GRP), the mammalian equivalent of bombesin (BN). There is some evidence to suggest that GRP is an autocrine regulator of SCLC cell growth. In the search for pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45a5b8f3eb984d197d424735920d5ed1
https://doi.org/10.1002/ijc.2910600112
https://doi.org/10.1002/ijc.2910600112
Autor:
Antal Orosz, Moritz Magens, Csaba Somlai, Ralf Ludwig, Enno Schmidt, Detlef Zillikens, Ralf Müller, Rudolf A. Manz, Christoph M. Hammers, Michael Kasperkiewicz, Jürgen Westermann
Publikováno v:
Blood. 117(23)
Blocking heat-shock protein 90 (Hsp90) induces death of malignant plasma cells by activation of the unfolded protein response, a signaling pathway activated by accumulation of misfolded proteins within the endoplasmic reticulum. We hypothesized that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3eade400db7ecc42baa167a7239fb5c
https://pubmed.ncbi.nlm.nih.gov/21490339
https://pubmed.ncbi.nlm.nih.gov/21490339
Publikováno v:
Drug and Alcohol Dependence. 32:107-111
Cytosolic free Ca2+ functions as a main regulator of numerous cellular processes, including those implicated in synthesis, release and responsiveness of hormones and neurotransmitters are discussed. To examine whether a change in the intracellular fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6dcd893134fd8a1ff93a81ffff269f7
https://doi.org/10.1016/0376-8716(93)80002-v
https://doi.org/10.1016/0376-8716(93)80002-v
Autor:
Joseph, Molnár, Helga, Engi, Yvette, Mándi, Csaba, Somlai, Botond, Penke, Andrea, Szabó, Antal, Orosz
Publikováno v:
In vivo (Athens, Greece). 21(2)
Novel heat shock protein 90 inhibitor peptide derivatives [D- Trp-Phe-D- Trp-Leu-AMB (1), p-HOPA-D- TrpPhe-D-Trp-Leu-psi(CH2NH)-Leu-NH2 (2), D-Trp-Phe-D-Trp-OH (3), Suc-D-Trp-Phe-D-Trp-Leu-AMB (4), D-Tyr-Phe-D-Trp-Leu-AMB (5), D-Arg-D-Trp-Phe-D-Trp-L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::59cd23ce8ddecb93154932be154754a5
https://pubmed.ncbi.nlm.nih.gov/17436599
https://pubmed.ncbi.nlm.nih.gov/17436599
Autor:
Gabriella Szeman, Botond Penke, Csaba Somlai, Andrea Szabó, Andrea Bodor, András Perczel, Antal Orosz, Tamás Janáky
Publikováno v:
The international journal of biochemistrycell biology. 38(8)
Almost all heat shock protein 90 inhibitors reported so far, which are natural product derivatives, have problems mainly with toxic side effects, and with bioavailability and solubility. In our earlier studies, we compared the steric conformational s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d9aaa56d13c8d76e9dc76f89f87c10
https://pubmed.ncbi.nlm.nih.gov/16540363
https://pubmed.ncbi.nlm.nih.gov/16540363
Publikováno v:
Biopolymers. 78(1)
In this study we compared the steric structures of the bioactive part of substance P (SP[6-11]) and its analogs (NY3460 and pHOPA-SP5). The molecular dynamics-simulated annealing method was used to explore the conformational space, and the structural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a1083509ca6a4e4868b0a14d922265ff
https://pubmed.ncbi.nlm.nih.gov/15786438
https://pubmed.ncbi.nlm.nih.gov/15786438
Autor:
Bartha Laszlo, János Schrett, Olga Nyeki, Attila Rill, Antal Orosz, István Schőn, József Nagy
Publikováno v:
Journal of peptide science : an official publication of the European Peptide Society. 4(8)
Small cell lung cancer (SCLC) cell lines produce and secrete various peptide hormones, e.g. bombesin (BN)/gastrin releasing peptide (GRP) like peptides that are proposed to function as their autocrine growth factors. To inhibit the proliferative effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3956dd32fa020e6a8695f22e056cd51d
https://pubmed.ncbi.nlm.nih.gov/9927255
https://pubmed.ncbi.nlm.nih.gov/9927255