Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Antal Harsanyi"'
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 10, Iss 1, Pp 1213-1219 (2014)
Diethyl 2-fluoromalonate ester is utilised as a building block for the synthesis of 2-fluoro-2-arylacetic acid and fluorooxindole derivatives by a strategy involving nucleophilic aromatic substitution reactions with ortho-fluoronitrobenzene substrate
Externí odkaz:
https://doaj.org/article/869a031fcdd9452fb435ff1c9e90b86e
Publikováno v:
CHIMIA, Vol 68, Iss 6 (2014)
A short series of fluorotetrahydroquinolines was synthesised in two steps from diethyl fluoromalonate and appropriate ortho-nitrobenzyl bromide precursors.
Externí odkaz:
https://doaj.org/article/b72bfa18a4ec4c5bb00b8f9407b4f25a
Autor:
Hugh Clark, Peter Szeto, Robert N. Bream, Alan Ironmonger, John D. Hayler, Nadine Mc Cleary, Alastair J. Roberts, Edney Dean David, Catherine Priestley, Michael R. Webb, Antal Harsanyi, Katherine Wheelhouse, Philip J. Rushworth, Natalie Phillips
Publikováno v:
Organic Process Research & Development. 25:529-540
This paper describes the development of an improved and scalable method for the manufacture of nemiralisib, a phosphatidylinositol-3-kinase delta inhibitor. Incorporation of three consecutive catal...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4d2497481e3451bd75cd43c57a09320
https://doi.org/10.1021/acs.oprd.0c00486
https://doi.org/10.1021/acs.oprd.0c00486
Autor:
Antal Harsanyi, Zahide Yilmaz, Anne Lückener, Dmitry S. Yufit, Lawrence Tam, Hedvig Pasztor, Graham Sandford
Publikováno v:
European Journal of Organic Chemistry. 2020:3872-3878
Fluorinated acyl‐Meldrum’s acid derivatives were synthesised by electrophilic fluorination of appropriate phenacyl Meldrum’s acid substrates using Selectfluor. Reactions with water, ethanol, Grignard and alkynyl lithium reagents gave rise to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5987360f5dceabe0fbc686ec54b1fac
https://doi.org/10.1002/ejoc.202000503
https://doi.org/10.1002/ejoc.202000503
Publikováno v:
European Journal of Organic Chemistry. 2019:7666-7672
2,3,3,3‐Tetrafluoropropene (HFO‐1234yf) is an inexpensive and readily available fluorinated building block, owing to its growing use as a low global warming potential 4th generation refrigerant, but there have so far been few reported uses of thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1909a12b4554d42561e2ce6646ec293
https://doi.org/10.1002/ejoc.201901445
https://doi.org/10.1002/ejoc.201901445
Autor:
Lee T. Boulton, Antal Harsanyi, Ben J. Murray, Graham Sandford, Dmitri S. Yufit, Thomas G. F. Marsh, Mark A. Fox
Publikováno v:
European journal of organic chemistry, 2020, Vol.2020(39), pp.6236-6244 [Peer Reviewed Journal]
Reaction of low cost, readily available 4th generation refrigerant gas 2,3,3,3‐tetrafluoropropene (HFO‐1234yf) with lithium diisopropylamide (LDA) leads to formation of lithium 3,3,3‐trifluoropropynide, addition of which to a range of aldehydes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bef34578bfd91a900451331e9bf34bb2
http://dro.dur.ac.uk/31725/
http://dro.dur.ac.uk/31725/
Autor:
Alexander S. Cook, Antal Harsanyi, Ben J. Murray, David R. W. Hodgson, Emily J. Chin, Neshat Rozatian, Alexander S. Hampton, Graham Sandford
Publikováno v:
Chemistry-a European journal, 2020, Vol.26(52), pp.12027-12035 [Peer Reviewed Journal]
Chemistry (Weinheim an Der Bergstrasse, Germany)
Chemistry (Weinheim an Der Bergstrasse, Germany)
Fluorinated steroids, which are synthesised by electrophilic fluorination, form a significant proportion of marketed pharmaceuticals. To gain quantitative information on fluorination at the 6‐position of steroids, kinetics studies were conducted on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f371c198170abd116062bee0528249dc
https://doi.org/10.1002/chem.202001120
https://doi.org/10.1002/chem.202001120
Autor:
Sandrine Grenier, Antal Harsanyi, Alain Rabion, Laurent Pichon, Annelyse Conte, Graham Sandford
Publikováno v:
Organic Process Research & Development. 21:273-276
In Africa around 625 000 mortalities per annum (20% of HIV/AIDS related deaths) are due to the affects of the Cryptococcal meningitis (CM) fungal infection. Recently, the World Health Organisation (WHO) and the Infectious Disease Society of America (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00a9a2e33f376c92d1192e064e413fb4
https://doi.org/10.1021/acs.oprd.6b00420
https://doi.org/10.1021/acs.oprd.6b00420
Autor:
Joseph P. Adams, Craig A. Fisher, Antal Harsanyi, Lena Shukla, Nicky J. Willis, Graham Sandford, Catherine M. Alder
Publikováno v:
Green chemistry, 2016, Vol.18(5), pp.1313-1318 [Peer Reviewed Journal]
Pharmaceutically important chiral fluorolactam derivatives bearing a fluorine atom at a stereogenic centre were synthesized by a route involving copper catalyzed selective direct fluorination using fluorine gas for the construction of the key C–F b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1492bf1a5806638a30f80655484fcd6
https://doi.org/10.1039/c5gc02209f
https://doi.org/10.1039/c5gc02209f
Publikováno v:
Journal of Fluorine Chemistry. 132:1241-1246
Various aryl-, heteroaryl-, and alkyl mercaptanes (RSH, 1a – r ) were treated with a slight excess of NaH suspended in DMF to make the appropriate sodium thiolates (RSNa), which then reacted with 1.3 equivalent of CF 3 I at room temperature for ove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ba8ba3bd28429b4327bb8119252fe27
https://doi.org/10.1016/j.jfluchem.2011.07.008
https://doi.org/10.1016/j.jfluchem.2011.07.008