Zobrazeno 1 - 10
of 96
pro vyhledávání: '"António Sebastião Rodrigues"'
Publikováno v:
Epigenetics, Vol 17, Iss 13, Pp 1961-1975 (2022)
Methylation microarray and bisulphite sequencing are often used to study 5’-methylcytosine (5’-mC) modification of CpG dinucleotides in the human genome. Although both technologies produce trustworthy results, the evaluation of the methylation st
Externí odkaz:
https://doaj.org/article/8138330d18e9473caf7a14d39d58b0c6
Autor:
Ana Cabrita, Alexandra M. Medeiros, Telmo Pereira, António Sebastião Rodrigues, Michel Kranendonk, César S. Mendes
Publikováno v:
iScience, Vol 25, Iss 7, Pp 104541- (2022)
Summary: Adequate alternatives to conventional animal testing are needed to study developmental neurotoxicity (DNT). Here, we used kinematic analysis to assess DNT of known (toluene (TOL) and chlorpyrifos (CPS)) and putative (β-N-methylamino-L-alani
Externí odkaz:
https://doaj.org/article/472de6d11e1f4a76857f1b46db1db26d
Autor:
Marília Ladeira de Araújo, Bruno Costa Gomes, Paula Pícoli Devóz, Nathália de Assis Aguilar Duarte, Diego Luis Ribeiro, Adriana Ladeira de Araújo, Bruno Lemos Batista, Lusânia Maria Greggi Antunes, Fernando Barbosa, António Sebastião Rodrigues, José Rueff, Gustavo Rafael Mazzaron Barcelos
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Experimental and epidemiologic studies have shown that lead (Pb) is able to induce epigenetic modifications, such as changes in DNA methylation profiles, in chromatin remodeling, as well as the expression of non-coding RNAs (ncRNAs). However, very li
Externí odkaz:
https://doaj.org/article/12e43e3e7c994f408ae47469f22107dd
Autor:
Marta Coelho, Carla Oliveira, Ezequiel R. Coscueta, João Fernandes, Ricardo N. Pereira, José A. Teixeira, António Sebastião Rodrigues, Manuela E. Pintado
Publikováno v:
Foods, Vol 11, Iss 7, p 1064 (2022)
A nutrient-rich diet is a key to improving the chemical signals, such as antioxidants, which modulate pathogens’ resistance in the gut and prevent diseases. A current industrial problem is the generation of undervalued by-products, such as tomato b
Externí odkaz:
https://doaj.org/article/a462a69923b94f42ac49890b6c07f1db
Autor:
Lis Lobo, Lília I. L. Cabral, Maria Inês Sena, Bruno Guerreiro, António Sebastião Rodrigues, Valter Ferreira de Andrade-Neto, Maria L. S. Cristiano, Fatima Nogueira
Publikováno v:
Malaria Journal, Vol 17, Iss 1, Pp 1-11 (2018)
Abstract Background The emergence and spread of Plasmodium falciparum resistance to artemisinin-based combination therapy in Southeast Asia prompted the need to develop new endoperoxide-type drugs. Methods A chemically diverse library of endoperoxide
Externí odkaz:
https://doaj.org/article/4416e7e1ecde49b7a505620739849133
Autor:
Marta Coelho, Sara Silva, Eduardo Costa, Ricardo N. Pereira, António Sebastião Rodrigues, José António Teixeira, Manuela Pintado
Publikováno v:
Molecules, Vol 26, Iss 13, p 3838 (2021)
Usually, wine-making by-products are discarded, presenting a significant environmental impact. However, they can be used as a source of bioactive compounds. Moreover, consumers’ increasing demand for naturally nutritious and healthy products requir
Externí odkaz:
https://doaj.org/article/9f7675423cf94904b70eb91e3a9371cb
Autor:
Kinanga Kiaco, António Sebastião Rodrigues, Virgílio do Rosário, José Pedro Gil, Dinora Lopes
Publikováno v:
Malaria Journal, Vol 16, Iss 1, Pp 1-6 (2017)
Abstract Malaria treatment performance is potentially influenced by pharmacogenetic factors. This study reports an association study between the ABCB1 c.3435C>T, CYP3A4*1B (g.-392A>G), CYP3A5*3 (g.6986A>G) SNPs and artemether + lumefantrine treatment
Externí odkaz:
https://doaj.org/article/54118b330905434ca135e6f780f51845
Autor:
Marta C. Coelho, Tânia B. Ribeiro, Carla Oliveira, Patricia Batista, Pedro Castro, Ana Rita Monforte, António Sebastião Rodrigues, José Teixeira, Manuela Pintado
Publikováno v:
Foods, Vol 10, Iss 3, p 554 (2021)
In times of pandemic and when sustainability is in vogue, the use of byproducts, such as fiber-rich tomato byproducts, can be an asset. There are still no studies on the impact of extraction methodologies and the gastrointestinal tract action on bioa
Externí odkaz:
https://doaj.org/article/a10f58d39710472c9229926a026648a2
Publikováno v:
Epigenetics. 17(13)
Methylation microarray and bisulphite sequencing are often used to study 5'-methylcytosine (5'-mC) modification of CpG dinucleotides in the human genome. Although both technologies produce trustworthy results, the evaluation of the methylation status
Autor:
Saudade André, António Sebastião Rodrigues, José Rueff, Susana N. Silva, Ana Félix, Bruno Gomes
Publikováno v:
Breast Cancer Research and Treatment
Background Breast cancer (BC) is the most common cancer in women. In contrast, male BC is about 100 times less common than in women, being considered a rare disease. Male BC may be a distinctive subtype of BC and available data seems to indicate that