Zobrazeno 1 - 10
of 26
pro vyhledávání: '"António J Preto"'
Autor:
António J. Preto, Ana B. Caniceiro, Francisco Duarte, Hugo Fernandes, Lino Ferreira, Joana Mourão, Irina S. Moreira
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-13 (2024)
Abstract Cell-penetrating peptides (CPPs) are short chains of amino acids that have shown remarkable potential to cross the cell membrane and deliver coupled therapeutic cargoes into cells. Designing and testing different CPPs to target specific cell
Externí odkaz:
https://doaj.org/article/1d60b1471b364deaa8b2dd29a823412c
Autor:
Ana B. Caniceiro, Beatriz Bueschbell, Carlos A.V. Barreto, António J. Preto, Irina S. Moreira
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 586-600 (2023)
G protein-coupled receptors (GPCRs) mediate several signaling pathways through a general mechanism that involves their activation, upholding a chain of events that lead to the release of molecules responsible for cytoplasmic action and further regula
Externí odkaz:
https://doaj.org/article/aeff22ed4fea4ad29625b37b5c201ab4
Autor:
Carlos A. V. Barreto, Salete J. Baptista, António J. Preto, Daniel Silvério, Rita Melo, Irina S. Moreira
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
This paper describes an exciting big data analysis compiled in a freely available database, which can be applied to characterize the coupling of different G-Protein coupled receptors (GPCRs) families with their intracellular partners. Opioid receptor
Externí odkaz:
https://doaj.org/article/c80fb0d774114aedad8ef7a6cbb04402
Autor:
Carlos A.V. Barreto, Salete J. Baptista, Beatriz Bueschbell, Pedro R. Magalhães, António J. Preto, Agostinho Lemos, Nícia Rosário‐Ferreira, Anke C. Schiedel, Miguel Machuqueiro, Rita Melo, Irina S. Moreira
Publikováno v:
GPCRs as Therapeutic Targets. :109-179
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 4, p 1511 (2020)
Influenza (flu) is a contagious viral disease, which targets the human respiratory tract and spreads throughout the world each year. Every year, influenza infects around 10% of the world population and between 290,000 and 650,000 people die from it a
Externí odkaz:
https://doaj.org/article/37ee26a7d1884082831c496079fcb3b1
Autor:
Beatriz Bueschbell, Carlos A. V. Barreto, António J. Preto, Anke C. Schiedel, Irina S. Moreira
Publikováno v:
Molecules, Vol 24, Iss 7, p 1196 (2019)
Background: Selectively targeting dopamine receptors (DRs) has been a persistent challenge in the last years for the development of new treatments to combat the large variety of diseases involving these receptors. Although, several drugs have been su
Externí odkaz:
https://doaj.org/article/bd08a33d1ce24259b622b43b0a4cb6c3
Autor:
Irina S. Moreira, João D. G. Correia, Pedro Matos-Filipe, Beatriz Bueschbell, Rúben D M Silva, Agostinho Lemos, Jose G. Almeida, António J Preto, Carlos A. V. Barreto, Rita Melo
Publikováno v:
Current Medicinal Chemistry. 27:760-794
Paediatric Acquired ImmunoDeficiency Syndrome (AIDS) is a life-threatening and infectious disease in which the Human Immunodeficiency Virus (HIV) is mainly transmitted through Mother-To- Child Transmission (MTCT) during pregnancy, labour and delivery
High-throughput screening technologies continues to produce large amounts of multiomics data from different populations and cell types for various diseases, such as cancer. However, analysis of such data encounters difficulties due to cancer heteroge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63bf191a829ac9e6f8fdb877a9f88663
Autor:
António J Preto, Irina S. Moreira
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 19
International Journal of Molecular Sciences, Vol 21, Iss 7281, p 7281 (2020)
Volume 21
Issue 19
International Journal of Molecular Sciences, Vol 21, Iss 7281, p 7281 (2020)
Protein Hot-Spots (HS) are experimentally determined amino acids, key to small ligand binding and tend to be structural landmarks on protein&ndash
protein interactions. As such, they were extensively approached by structure-based Machine Learnin
protein interactions. As such, they were extensively approached by structure-based Machine Learnin
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2190
Targeting protein-protein interactions is a challenge and crucial task of the drug discovery process. A good starting point for rational drug design is the identification of hot spots (HS) at protein-protein interfaces, typically conserved residues t