Zobrazeno 1 - 10
of 50
pro vyhledávání: '"António Francisco Ambrósio"'
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-23 (2024)
Abstract Retinal degenerative diseases, including diabetic retinopathy (DR) and age-related macular degeneration (AMD), loom as threats to vision, causing detrimental effects on the structure and function of the retina. Central to understanding these
Externí odkaz:
https://doaj.org/article/7fef45ae10404fb28d79e09f2e9ed516
Autor:
Ana Batista, Pedro Guimarães, João Martins, Paula I. Moreira, António Francisco Ambrósio, Miguel Castelo-Branco, Pedro Serranho, Rui Bernardes
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
Externí odkaz:
https://doaj.org/article/61af8db1d68148efa888d0d3dbf83363
Autor:
Xandra Pereiro, Noelia Ruzafa, Mikel Azkargorta, Félix Elortza, Arantxa Acera, António Francisco Ambrósio, Ana Raquel Santiago, Elena Vecino
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract Background Glaucoma, a progressive neurodegenerative disease, is a leading cause of irreversible vision loss worldwide. This study aims to elucidate the critical role of Müller glia (MG) in the context of retinal ganglion cell (RGC) death,
Externí odkaz:
https://doaj.org/article/491651dcd05c4a1d81e455eb29f8feed
Autor:
Hugo Ferreira, Pedro Serranho, Pedro Guimarães, Rita Trindade, João Martins, Paula I. Moreira, António Francisco Ambrósio, Miguel Castelo-Branco, Rui Bernardes
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-7 (2022)
Abstract The early diagnosis of neurodegenerative disorders is still an open issue despite the many efforts to address this problem. In particular, Alzheimer’s disease (AD) remains undiagnosed for over a decade before the first symptoms. Optical co
Externí odkaz:
https://doaj.org/article/42450e8b9f694be5953cea0211e412a2
Autor:
Paulo F. Santos, Beatriz Fazendeiro, Francis C. Luca, António Francisco Ambrósio, Hélène Léger
Publikováno v:
European Journal of Cell Biology, Vol 102, Iss 2, Pp 151333- (2023)
Nuclear Dbf2-related (NDR) kinases are a subgroup of evolutionarily conserved AGC protein kinases that regulate various aspects of cell growth and morphogenesis. There are 4 NDR protein kinases in mammals, LATS1, LATS2 and STTK8/NDR1, STK38L/NDR2 pro
Externí odkaz:
https://doaj.org/article/36fd8a03331e478399c077f03bde73f4
Autor:
Ana Batista, Pedro Guimarães, João Martins, Paula I. Moreira, António Francisco Ambrósio, Miguel Castelo-Branco, Pedro Serranho, Rui Bernardes
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
Animal models of disease are paramount to understand retinal development, the pathophysiology of eye diseases, and to study neurodegeneration using optical coherence tomography (OCT) data. In this study, we present a comprehensive normative database
Externí odkaz:
https://doaj.org/article/83bf9c761e2847f2a0f380954acccc26
Autor:
Ana Batista, Pedro Guimarães, Pedro Serranho, Ana Nunes, João Martins, Paula I. Moreira, António Francisco Ambrósio, Miguel Morgado, Miguel Castelo-Branco, Rui Bernardes
Publikováno v:
Frontiers in Ophthalmology, Vol 3 (2023)
There is a pressing need for novel diagnostic and progression biomarkers of neurodegeneration. However, the inability to determine disease duration and stage in patients with Alzheimer’s disease (AD) hinders their discovery. Because animal models o
Externí odkaz:
https://doaj.org/article/f6dae48a28124f9aa23431a24e676182
Autor:
Pedro Guimarães, Pedro Serranho, João Martins, Paula I. Moreira, António Francisco Ambrósio, Miguel Castelo-Branco, Rui Bernardes
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
The retina, as part of the central nervous system (CNS), can be the perfect target for in vivo, in situ, and noninvasive neuropathology diagnosis and assessment of therapeutic efficacy. It has long been established that several age-related brain chan
Externí odkaz:
https://doaj.org/article/340b70aafd74417d855cf1d3048550f7
Autor:
Madania Amorim, Beatriz Martins, Francisco Caramelo, Conceição Gonçalves, Grimalde Trindade, Jorge Simão, Patrícia Barreto, Inês Marques, Ermelindo Carreira Leal, Eugénia Carvalho, Flávio Reis, Teresa Ribeiro-Rodrigues, Henrique Girão, Paulo Rodrigues-Santos, Cláudia Farinha, António Francisco Ambrósio, Rufino Silva, Rosa Fernandes
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
PurposeTear fluid biomarkers may offer a non-invasive strategy for detecting diabetic patients with increased risk of developing diabetic retinopathy (DR) or increased disease progression, thus helping both improving diagnostic accuracy and understan
Externí odkaz:
https://doaj.org/article/6e64366ffa494e64abebfa6d1a944647
Autor:
Eliane S. Sanches, Raquel Boia, Ricardo A. Leitão, Maria H. Madeira, Carlos A. Fontes-Ribeiro, António Francisco Ambrósio, Rosa Fernandes, Ana Paula Silva
Publikováno v:
Antioxidants, Vol 12, Iss 4, p 937 (2023)
Attention-Deficit/Hyperactivity Disorder (ADHD) is one of the most prevalent neurodevelopmental disorders. Interestingly, children with ADHD seem to experience more ophthalmologic abnormalities, and the impact of methylphenidate (MPH) use on retinal
Externí odkaz:
https://doaj.org/article/abb42e0a30ce4cc2b448ace92c58ec66