Zobrazeno 1 - 10
of 181
pro vyhledávání: '"António F, Ambrósio"'
Autor:
Renato Socodato, Tiago O. Almeida, Camila C. Portugal, Evelyn C.S. Santos, Joana Tedim-Moreira, João Galvão-Ferreira, Teresa Canedo, Filipa I. Baptista, Ana Magalhães, António F. Ambrósio, Cord Brakebusch, Boris Rubinstein, Irina S. Moreira, Teresa Summavielle, Inês Mendes Pinto, João B. Relvas
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113447- (2023)
Summary: Microglia, the largest population of brain immune cells, continuously interact with synapses to maintain brain homeostasis. In this study, we use conditional cell-specific gene targeting in mice with multi-omics approaches and demonstrate th
Externí odkaz:
https://doaj.org/article/914f35ba494042d8aa265dd02cbdf0a4
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Schizophrenia is a psychiatric disorder with significant impact on individuals and society. The current pharmacologic treatment, which principally alleviates psychosis, is focused on neurotransmitters modulation, relying on drugs with severe
Externí odkaz:
https://doaj.org/article/d1fcd182b0d84ce491a5886bb21f1ced
Autor:
Carla Filipa Simões-Henriques, A. Catarina Rodrigues-Neves, Fábio J. Sousa, Rita Gaspar, Inês Almeida, Filipa I. Baptista, António F. Ambrósio, Catarina A. Gomes
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
The involvement of immunity in psychiatric disorders, such as anxiety, is typified by the morphologic adaptation of microglia, immune cells of the brain, to anxiogenic stimuli. We previously reported sexually differentiated microglia morphology in ad
Externí odkaz:
https://doaj.org/article/687e04dfefae464797f0beeea699c0fa
Autor:
Rita Gaspar, Carina Soares-Cunha, Ana Verónica Domingues, Bárbara Coimbra, Filipa I. Baptista, Luísa Pinto, António F. Ambrósio, Ana João Rodrigues, Catarina A. Gomes
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 16 (2022)
Stress exposure has been shown to induce a variety of molecular and functional alterations associated with anxiety and depression. Some studies suggest that microglia, the immune cells of the brain, play a significant role in determining neuronal and
Externí odkaz:
https://doaj.org/article/75dba4dd43fc4e86ab13b2ea9edd5f81
Autor:
Rita Gaspar, Carina Soares-Cunha, Ana Verónica Domingues, Bárbara Coimbra, Filipa I. Baptista, Luísa Pinto, António F. Ambrósio, Ana João Rodrigues, Catarina A. Gomes
Publikováno v:
Neurobiology of Stress, Vol 14, Iss , Pp 100302- (2021)
Prenatal exposure to stress or glucocorticoids (GC) is associated with the appearance of psychiatric diseases later in life. Microglia, the immune cells of the brain, are altered in stress-related disorders.Synthetic GC such as dexamethasone (DEX) ar
Externí odkaz:
https://doaj.org/article/c7022f8cf5f842d49fe2e113aea12556
Autor:
Fábio J. Sousa, Raquel G. Correia, Alexandra F. Cruz, Joana M. Martins, Matilde S. Rodrigues, Catarina A. Gomes, António F. Ambrósio, Filipa I. Baptista
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 5, Iss , Pp 100075- (2020)
Diabetes during pregnancy has been shown to affect the central nervous system (CNS) of the offspring, resulting in short- and long-term adverse effects. Children of diabetic mothers are more likely to develop cognitive impairment, also having increas
Externí odkaz:
https://doaj.org/article/78380c8113c046a3bbd7354c49562554
Autor:
Maria Vieira, Rosa Fernandes, António F. Ambrósio, Vanessa Cardoso, Mariana Carvalho, Peng Weng Kung, Miguel António Dias Neves, Inês Mendes Pinto
Publikováno v:
Lab on a Chip. 22:1876-1889
Diabetic retinopathy (DR) is the most common diabetic eye disease and the worldwide leading cause of vision loss in working-age adults. It progresses from mild to severe non-proliferative or proliferative DR based on several pathological features inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7b65c9a2c304cbbfd4192b4ec4e6607
https://doi.org/10.1039/d1lc01138c
https://doi.org/10.1039/d1lc01138c
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Oxidative stress plays key roles in the pathogenesis of retinal diseases, such as diabetic retinopathy. Reactive oxygen species (ROS) are increased in the retina in diabetes and the antioxidant defense system is also compromised. Increased ROS stimul
Externí odkaz:
https://doaj.org/article/160604315d5e41c2ae8f24fa0b53cd17
Autor:
João O. Malva, Alda Amado, Alexandra Rodrigues, Anabela Mota-Pinto, Ana F. Cardoso, Ana M. Teixeira, Ana Todo-Bom, António Devesa, António F. Ambrósio, António L. Cunha, Bárbara Gomes, Carina Dantas, Cidalina Abreu, Isabel Santana, Jean Bousquet, João Apóstolo, Lúcia Santos, Lúcio Meneses de Almeida, Maddalena Illario, Rafaela Veríssimo, Vitor Rodrigues, Manuel T. Veríssimo
Publikováno v:
Frontiers in Medicine, Vol 5 (2018)
Challenges posed by demographic changes and population aging are key priorities for the Horizon 2020 Program of the European Commission. Aligned with the vision of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA), the dev
Externí odkaz:
https://doaj.org/article/886ea5e203a04d54bc86161b66a3abd2
Autor:
Helena Pinheiro, Rita Gaspar, Filipa I. Baptista, Carlos A. Fontes-Ribeiro, António F. Ambrósio, Catarina A. Gomes
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
The exposure to supra-physiological levels of glucocorticoids in prenatal life can lead to a long-term impact in brain cytoarchitecture, increasing the susceptibility to neuropsychiatric disorders. Dexamethasone, an exogenous glucocorticoid widely us
Externí odkaz:
https://doaj.org/article/a137c705153f47cdbae5aa74e144b26c