Comparison between integrated continuous direct compression line and batch processing – The effect of raw material properties

Autor: Susanna Abrahmsén-Alami, Håkan Wikström, Anders Sparén, Ossi Korhonen, Magnus Fransson, Anssi-Pekka Karttunen, Mariagrazia Marucci, Jarkko Ketolainen, Staffan Folestad, Pirjo Tajarobi

Publikováno v: European Journal of Pharmaceutical Sciences. 133:40-53

There is a current trend in pharmaceutical manufacturing to shift from traditional batch manufacture to continuous manufacturing. The purpose of this study was to test the ability of an integrated continuous direct compression (CDC) line, in relation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac8d771f6a5c25b8019850877bbf791e
https://doi.org/10.1016/j.ejps.2019.03.001

Simultaneous investigation of the liquid transport and swelling performance during tablet disintegration

Autor: J. Axel Zeitler, Theona Mudley, Jarkko Ketolainen, Kai-Erik Peiponen, Mohammed Al-Sharabi, Cathy J. Ridgway, Thomas Rades, Daniel Markl, Prince Bawuah, Patrick A.C. Gane, Anssi-Pekka Karttunen

Publikováno v: Al-Sharabi, M, Markl, D, Mudley, T, Bawuah, P, Karttunen, A-P, Ridgway, C, Gane, P, Ketolainen, J, Peiponen, K-E, Rades, T & Zeitler, J A 2020, ' Simultaneous investigation of the liquid transport and swelling performance during tablet disintegration ', International Journal of Pharmaceutics, vol. 584, 119380 . https://doi.org/10.1016/j.ijpharm.2020.119380

Fast disintegrating tablets have commonly been used for fast oral drug delivery to patients with swallowing difficulties. The different characteristics of the pore structure of such formulations influence the liquid transport through the tablet and h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::400f107d165a5aba2a5d4b9e3e2f3e21
https://doi.org/10.1016/j.ijpharm.2020.119380

Measurement of residence time distributions and material tracking on three continuous manufacturing lines

Autor: Fien De Leersnyder, Anssi Pekka Karttunen, Thomas De Beer, Jarkko Ketolainen, Ossi Korhonen, Theresa Hörmann, Wen Kai Hsiao

Publikováno v: International journal of pharmaceutics. 563

Over the recent decade, benefits of continuous manufacturing (CM) of pharmaceutical products have been acknowledged widely. In contrast to batch processes, the product is not physically separated into batches in CM, which creates a few challenges. Pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b623a5aab4975e02a4b30b08d883b5e8
https://pubmed.ncbi.nlm.nih.gov/30930190

RTD-based material tracking in a fully-continuous dry granulation tableting line

Autor: Johannes Khinast, Patrick Wahl, Ossi Korhonen, Anssi-Pekka Karttunen, Michael Martinetz, Stephan Sacher, Jarkko Ketolainen

Publikováno v: International journal of pharmaceutics. 547(1-2)

Continuous manufacturing (CM) offers quality and cost-effectiveness benefits over currently dominating batch processing. One challenge that needs to be addressed when implementing CM is traceability of materials through the process, which is needed f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b91e2859ac0dcf57a74b907290fc9a7
https://pubmed.ncbi.nlm.nih.gov/29885512

Lubricant based determination of design space for continuously manufactured high dose paracetamol tablets

Autor: Ossi Korhonen, Jarkko Ketolainen, Krista Taipale-Kovalainen, Anssi-Pekka Karttunen

Publikováno v: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 115

The objective of this study was to devise robust and stable continuous manufacturing process settings, by exploring the design space after an investigation of the lubrication-based parameters influencing the continuous direct compression tableting of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95e302cd4fe91e17ad2519fdc5b5b24d
https://pubmed.ncbi.nlm.nih.gov/29277668