Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19.

Autor: Boras B; Worldwide Research and Development, Pfizer Inc, La Jolla, CA, 92121, USA., Jones RM; Worldwide Research and Development, Pfizer Inc, La Jolla, CA, 92121, USA. rhys.jones@pfizer.com., Anson BJ; Department of Biological Sciences, Purdue University, West Lafayette, IN, 47907, USA., Arenson D; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA., Aschenbrenner L; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA., Bakowski MA; Calibr, a division of The Scripps Research Institute, La Jolla, CA, 92037, USA., Beutler N; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, 92037, USA., Binder J; Worldwide Research and Development, Pfizer Inc, La Jolla, CA, 92121, USA., Chen E; Calibr, a division of The Scripps Research Institute, La Jolla, CA, 92037, USA., Eng H; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA., Hammond H; Department of Microbiology and Immunology University of Maryland School of Medicine, Baltimore, MD, 21201, USA., Hammond J; Worldwide Research and Development, Pfizer Inc., Collegeville, PA, 19426, USA., Haupt RE; Department of Microbiology and Immunology University of Maryland School of Medicine, Baltimore, MD, 21201, USA., Hoffman R; Worldwide Research and Development, Pfizer Inc, La Jolla, CA, 92121, USA., Kadar EP; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA., Kania R; Worldwide Research and Development, Pfizer Inc, La Jolla, CA, 92121, USA., Kimoto E; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA., Kirkpatrick MG; Calibr, a division of The Scripps Research Institute, La Jolla, CA, 92037, USA., Lanyon L; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA., Lendy EK; Department of Biochemistry, Purdue University, West Lafayette, IN, 47907, USA., Lillis JR; Worldwide Research and Development, Pfizer Inc, Sandwich, CT13 9ND, UK., Logue J; Department of Microbiology and Immunology University of Maryland School of Medicine, Baltimore, MD, 21201, USA., Luthra SA; Worldwide Research and Development, Pfizer Inc, Cambridge, MA, 02139, USA., Ma C; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, 85721, USA., Mason SW; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA.; Worldwide Research and Development, Pfizer Inc., Pearl River, NY, 10965, USA., McGrath ME; Department of Microbiology and Immunology University of Maryland School of Medicine, Baltimore, MD, 21201, USA., Noell S; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA., Obach RS; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA., O' Brien MN; Worldwide Research and Development, Pfizer Inc, Lake Forest, IL, 60045, USA., O'Connor R; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA., Ogilvie K; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA., Owen D; Worldwide Research and Development, Pfizer Inc, Cambridge, MA, 02139, USA., Pettersson M; Worldwide Research and Development, Pfizer Inc, Cambridge, MA, 02139, USA., Reese MR; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA., Rogers TF; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, 92037, USA.; UC San Diego Division of Infectious Diseases and Global Public Health, UC San Diego School of Medicine, La Jolla, CA, 92093, USA., Rosales R; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Rossulek MI; Worldwide Research and Development, Pfizer Inc, Cambridge, MA, 02139, USA., Sathish JG; Worldwide Research and Development, Pfizer Inc., Pearl River, NY, 10965, USA., Shirai N; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA., Steppan C; Worldwide Research and Development, Pfizer Inc, Groton, CT, 06340, USA., Ticehurst M; Worldwide Research and Development, Pfizer Inc, Sandwich, CT13 9ND, UK., Updyke LW; Worldwide Research and Development, Pfizer Inc, Cambridge, MA, 02139, USA., Weston S; Department of Microbiology and Immunology University of Maryland School of Medicine, Baltimore, MD, 21201, USA., Zhu Y; Worldwide Research and Development, Pfizer Inc., Pearl River, NY, 10965, USA., White KM; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Wang J; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, 85721, USA., Chatterjee AK; Calibr, a division of The Scripps Research Institute, La Jolla, CA, 92037, USA., Mesecar AD; Department of Biological Sciences, Purdue University, West Lafayette, IN, 47907, USA.; Department of Biochemistry, Purdue University, West Lafayette, IN, 47907, USA., Frieman MB; Department of Microbiology and Immunology University of Maryland School of Medicine, Baltimore, MD, 21201, USA., Anderson AS; Worldwide Research and Development, Pfizer Inc., Pearl River, NY, 10965, USA., Allerton C; Worldwide Research and Development, Pfizer Inc, Cambridge, MA, 02139, USA.

Publikováno v: Nature communications [Nat Commun] 2021 Oct 18; Vol. 12 (1), pp. 6055. Date of Electronic Publication: 2021 Oct 18.

Chloropyridinyl Esters of Nonsteroidal Anti-Inflammatory Agents and Related Derivatives as Potent SARS-CoV-2 3CL Protease Inhibitors.

Autor: Ghosh AK; Department of Chemistry; Department of Medicinal Chemistry, Purdue University, West Lafayette, IN 47907, USA., Shahabi D; Department of Chemistry; Department of Medicinal Chemistry, Purdue University, West Lafayette, IN 47907, USA., Yadav M; Department of Chemistry; Department of Medicinal Chemistry, Purdue University, West Lafayette, IN 47907, USA., Kovela S; Department of Chemistry; Department of Medicinal Chemistry, Purdue University, West Lafayette, IN 47907, USA., Anson BJ; Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA., Lendy EK; Department of Biochemistry, Purdue University, West Lafayette, IN 47907, USA., Bonham C; Bindley Bioscience Center, Purdue University, West Lafayette, IN 47907, USA., Sirohi D; Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.; Purdue Institute of Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, IN 47907, USA., Brito-Sierra CA; Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.; Purdue Institute of Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, IN 47907, USA., Hattori SI; Departments of Hematology and Infectious Diseases, Kumamoto University School of Medicine, Kumamoto 860-8556, Japan.; Department of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute, Tokyo 162-8655, Japan., Kuhn R; Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.; Purdue Institute of Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, IN 47907, USA., Mitsuya H; Departments of Hematology and Infectious Diseases, Kumamoto University School of Medicine, Kumamoto 860-8556, Japan.; Department of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute, Tokyo 162-8655, Japan.; Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, Bethesda, MD 20892, USA., Mesecar AD; Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.; Department of Biochemistry, Purdue University, West Lafayette, IN 47907, USA.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2021 Sep 24; Vol. 26 (19). Date of Electronic Publication: 2021 Sep 24.

A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication.

Autor: Hattori SI; Department of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute, Tokyo, Japan., Higashi-Kuwata N; Department of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute, Tokyo, Japan., Hayashi H; Department of Intelligent Network for Infection Control, Tohoku University Hospital, Miyagi, Japan.; Department of infectious Diseases, International Research Institute of Disaster Science, Tohoku University, Miyagi, Japan., Allu SR; Department of Chemistry and Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA., Raghavaiah J; Department of Chemistry and Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA., Bulut H; Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Das D; Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Anson BJ; Department of Biochemistry and Department of Biological Sciences, Purdue University, West Lafayette, IN, USA., Lendy EK; Department of Biochemistry and Department of Biological Sciences, Purdue University, West Lafayette, IN, USA., Takamatsu Y; Department of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute, Tokyo, Japan., Takamune N; Kumamoto Innovative Development Organization, Kumamoto University, Kumamoto, Japan., Kishimoto N; Department of Environmental and Molecular Health Sciences, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan., Murayama K; Graduate School of Biomedical Engineering, Tohoku University, Miyagi, Japan., Hasegawa K; Protein Crystal Analysis Division, Japan Synchrotron Radiation Research Institute, Hyogo, Japan., Li M; Protein Structure Section, Center for Structural Biology, National Cancer Institute, Frederick, MD, USA.; Basic Science Program, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Davis DA; Viral Oncology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Kodama EN; Department of infectious Diseases, International Research Institute of Disaster Science, Tohoku University, Miyagi, Japan.; Department of Infectious Diseases, Graduate School of Medicine and Tohoku Medical Megabank Organization, Tohoku University, Miyagi, Japan., Yarchoan R; Viral Oncology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Wlodawer A; Protein Structure Section, Center for Structural Biology, National Cancer Institute, Frederick, MD, USA., Misumi S; Department of Environmental and Molecular Health Sciences, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan., Mesecar AD; Department of Biochemistry and Department of Biological Sciences, Purdue University, West Lafayette, IN, USA., Ghosh AK; Department of Chemistry and Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA., Mitsuya H; Department of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute, Tokyo, Japan. hmitsuya@hosp.ncgm.go.jp.; Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. hmitsuya@hosp.ncgm.go.jp.; Department of Clinical Sciences, Kumamoto University Hospital, Kumamoto, Japan. hmitsuya@hosp.ncgm.go.jp.

Publikováno v: Nature communications [Nat Commun] 2021 Jan 28; Vol. 12 (1), pp. 668. Date of Electronic Publication: 2021 Jan 28.

X-Ray Structure and Inhibition of 3C-like Protease from Porcine Epidemic Diarrhea Virus.

Autor: St John SE; Department of Chemistry, Purdue University, West Lafayette, Indiana, USA.; Centers for Cancer Research &Drug Discovery, Purdue University, West Lafayette, Indiana, USA.; Department of Biological Sciences, Purdue University, West Lafayette, Indiana, USA., Anson BJ; Department of Biological Sciences, Purdue University, West Lafayette, Indiana, USA., Mesecar AD; Department of Chemistry, Purdue University, West Lafayette, Indiana, USA.; Centers for Cancer Research &Drug Discovery, Purdue University, West Lafayette, Indiana, USA.; Department of Biological Sciences, Purdue University, West Lafayette, Indiana, USA.

Publikováno v: Scientific reports [Sci Rep] 2016 May 13; Vol. 6, pp. 25961. Date of Electronic Publication: 2016 May 13.

Surgical anatomy of the facial nerve.

Autor: Donaldson JA, Anson BJ

Publikováno v: Otolaryngologic clinics of North America [Otolaryngol Clin North Am] 1974 Jun; Vol. 7 (2), pp. 289-308.