Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Anshul Bhardwaj"'
Autor:
Maria Davern, Cillian O’ Donovan, Noel E. Donlon, Eimear Mylod, Caoimhe Gaughan, Anshul Bhardwaj, Andrew D. Sheppard, Dara Bracken-Clarke, Christine Butler, Narayanasamy Ravi, Claire L. Donohoe, John V. Reynolds, Joanne Lysaght, Melissa J. Conroy
Publikováno v:
Biomedicines, Vol 12, Iss 4, p 819 (2024)
The presence of an immunosuppressive tumour microenvironment in oesophageal adenocarcinoma (OAC) is a major contributor to poor responses. Novel treatment strategies are required to supplement current regimens and improve patient survival. This study
Externí odkaz:
https://doaj.org/article/3ca4eb6b6a0845a7a2adb872372af596
Autor:
Maria Davern, Noel E. Donlon, Fiona O’ Connell, Andrew D. Sheppard, Conall Hayes, Ross King, Hugo Temperley, Christine Butler, Anshul Bhardwaj, Jenny Moore, Dara Bracken-Clarke, Claire Donohoe, Narayanasamy Ravi, John V. Reynolds, Stephen G. Maher, Melissa J. Conroy, Joanne Lysaght
Publikováno v:
Translational Oncology, Vol 20, Iss , Pp 101406- (2022)
Response rates to immune checkpoint blockade (ICB) remain low in oesophageal adenocarcinoma (OAC). Combining ICB with immunostimulatory chemotherapies to boost response rates is an attractive approach for converting ‘cold’ tumours into ‘hot’
Externí odkaz:
https://doaj.org/article/c52c824c793a4acdab0d58f23a41159d
Autor:
Fiona O’Connell, Eimear Mylod, Noel E. Donlon, Aisling B. Heeran, Christine Butler, Anshul Bhardwaj, Sinead Ramjit, Michael Durand, Gerard Lambe, Paul Tansey, Ivan Welartne, Kevin P. Sheahan, Xiaofei Yin, Claire L. Donohoe, Narayanasamy Ravi, Margaret R. Dunne, Lorraine Brennan, John V. Reynolds, Helen M. Roche, Jacintha O’Sullivan
Publikováno v:
Cancers, Vol 15, Iss 6, p 1681 (2023)
Oesophageal adenocarcinoma (OAC) is a poor prognosis cancer with limited response rates to current treatment modalities and has a strong link to obesity. To better elucidate the role of visceral adiposity in this disease state, a full metabolic profi
Externí odkaz:
https://doaj.org/article/60f45e8ebed54b9eabadadf6e1e47dc7
Autor:
Noel E. Donlon, Maria Davern, Andrew D. Sheppard, Fiona O’Connell, Margaret R. Dunne, Conall Hayes, Eimear Mylod, Sinead Ramjit, Hugo Temperley, Michael Mac Lean, Gillian Cotter, Anshul Bhardwaj, Christine Butler, Melissa J. Conroy, Jacintha O’Sullivan, Narayanasamy Ravi, Claire L. Donohoe, John V. Reynolds, Joanne Lysaght
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundImmune checkpoint inhibitors (ICIs) are being investigated for their role as an adjunct in the multimodal treatment of esophageal adenocarcinoma (EAC). The most effective time to incorporate ICIs remains unknown. Our study profiles systemic
Externí odkaz:
https://doaj.org/article/c1c43e80139b48f2bdb847aa34f8da63
Autor:
Maria Davern, Noel E. Donlon, Andrew Sheppard, Fiona O’ Connell, Conall Hayes, Anshul Bhardwaj, Emma Foley, Dermot O’ Toole, Niamh Lynam-Lennon, Narayanasamy Ravi, John V. Reynolds, Stephen G. Maher, Joanne Lysaght
Publikováno v:
Translational Oncology, Vol 14, Iss 6, Pp 101062- (2021)
Use of immune checkpoint inhibitors (ICIs) with chemotherapy to enhance responses in oesophageal adenocarcinoma (OAC) is an attractive approach. We identified subpopulations of OAC cells expressing inhibitory immune checkpoint (IC) ligands (PD-L1, PD
Externí odkaz:
https://doaj.org/article/b7537352cc384062b787c2304e2e7b62
Autor:
John Reynolds, Maria Davern, Joanne Lysaght, Andrew Sheppard, Stephen Maher, Noel Donlon, Fiona Connell, Conall Hayes, Ross King, Anshul Bhardwaj
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/84e4bb63222e4a949b4446e187e06e0f
Autor:
Aisling B. Heeran, Jessica McCready, Margaret R. Dunne, Noel E. Donlon, Timothy S. Nugent, Anshul Bhardwaj, Kathleen A. J. Mitchelson, Amy M. Buckley, Narayanasamy Ravi, Helen M. Roche, John V. Reynolds, Niamh Lynam-Lennon, Jacintha O’Sullivan
Publikováno v:
Metabolites, Vol 11, Iss 11, p 768 (2021)
Oesophageal adenocarcinoma (OAC) is an exemplar model of obesity-associated cancer. Previous work in our group has demonstrated that overweight/obese OAC patients have better responses to neoadjuvant therapy, but the underlying mechanisms are unknown
Externí odkaz:
https://doaj.org/article/4b17fa7c7aa34e3fb57f33a4372a340f
Autor:
Noel E. Donlon, Maria Davern, Andrew Sheppard, Robert Power, Fiona O’Connell, Aisling B. Heeran, Ross King, Conall Hayes, Anshul Bhardwaj, James J. Phelan, Margaret R. Dunne, Narayanasamy Ravi, Claire L. Donohoe, Jacintha O’Sullivan, John V. Reynolds, Joanne Lysaght
Publikováno v:
Cancers, Vol 13, Iss 16, p 4005 (2021)
Response rates to the current gold standards of care for treating oesophageal adenocarcinoma (OAC) remain modest with 15–25% of patients achieving meaningful pathological responses, highlighting the need for novel therapeutic strategies. This study
Externí odkaz:
https://doaj.org/article/f9614f8892c540978cec164f122a4666
Autor:
Noel E. Donlon, Andrew Sheppard, Maria Davern, Fiona O’Connell, James J. Phelan, Robert Power, Timothy Nugent, Kate Dinneen, John Aird, John Greene, Paul Nevins Selvadurai, Anshul Bhardwaj, Emma K. Foley, Narayanasamy Ravi, Claire L. Donohoe, John V. Reynolds, Joanne Lysaght, Jacintha O’Sullivan, Margaret R. Dunne
Publikováno v:
Cancers, Vol 12, Iss 11, p 3356 (2020)
Esophageal adenocarcinoma (EAC) is an aggressive cancer with poor prognosis and incidence is increasing rapidly in the Western world. Multi-modal treatment has improved survival outcomes but only for a minority of patients. Currently no markers have
Externí odkaz:
https://doaj.org/article/b32420d768d24c7bb6414bf797b1d002
Autor:
Justin C Leavitt, Lasha Gogokhia, Eddie B Gilcrease, Anshul Bhardwaj, Gino Cingolani, Sherwood R Casjens
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70936 (2013)
The P22-like bacteriophages have short tails. Their virions bind to their polysaccharide receptors through six trimeric tailspike proteins that surround the tail tip. These short tails also have a trimeric needle protein that extends beyond the tails
Externí odkaz:
https://doaj.org/article/b958fa75de3a4062854540404f967f1f