Centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy

Autor: Weiguo Zhang, Jian-Hua Mao, Wei Zhu, Anshu K. Jain, Ke Liu, James B. Brown, Gary H. Karpen

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)

Centromeres and kinetochores are important in maintaining chromosomal stability. Here, the authors show that overexpression of a subset of centromere and kinetochore genes is associated with chromosomal instability and mutation burden in cancer, and

Externí odkaz: https://doaj.org/article/81d5d64089a14736a7f1215807ef737a

Phase IIb, Randomized, Double-Blind Trial of GC4419 Versus Placebo to Reduce Severe Oral Mucositis Due to Concurrent Radiotherapy and Cisplatin For Head and Neck Cancer

Autor: Philip Kovoor, Stephen T. Sonis, Kyle Colvett, Jeffrey Mark Brill, Madhur Garg, Neal Dunlap, James Wheeler, Roberto Arevalo-Araujo, Sharon M. Gordon, Francis P. Worden, Abhinand V. Peddada, Matthew Downs, Voichita Bar-Ad, Marcelo Bonomi, Anshu K. Jain, Christopher M. Lee, John M. Buatti, Chaitali Singh Nangia, Carryn M. Anderson, Deborah P. Saunders, Sanford Katz, Jon Holmlund, Amarinthia Curtis, Dukagjin Blakaj, Arielle S. Lee, Sanjiv S. Agarwala, Douglas C. Miller

Publikováno v: Journal of Clinical Oncology

PURPOSE Oral mucositis (OM) remains a common, debilitating toxicity of radiation therapy (RT) for head and neck cancer. The goal of this phase IIb, multi-institutional, randomized, double-blind trial was to compare the efficacy and safety of GC4419,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d92c333dc77d1b59aaa718cb6d031c3b
https://doi.org/10.1200/jco.19.01507

Centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy

Autor: Ke Liu, James B. Brown, Anshu K. Jain, Weiguo Zhang, Wei Zhu, Gary H. Karpen, Jian-Hua Mao

Publikováno v: Nature Communications
Nature communications, vol 7, iss 1
Zhang, W; Mao, JH; Zhu, W; Jain, AK; Liu, K; Brown, JB; et al.(2016). Centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy. Nature Communications, 7. doi: 10.1038/ncomms12619. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/12t1v6pn
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)

Chromosomal instability (CIN) is a hallmark of cancer that contributes to tumour heterogeneity and other malignant properties. Aberrant centromere and kinetochore function causes CIN through chromosome missegregation, leading to aneuploidy, rearrange

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63972c746318ec3143caec15855fb0c8
http://europepmc.org/articles/PMC5013662

Intensity-modulated radiotherapy for locally advanced cancers of the larynx and hypopharynx

Autor: Daniel T. Chang, Harlan A. Pinto, Anshu K. Jain, Michael J. Kaplan, Megan E. Daly, A Hsu, A. Dimitrios Colevas, Nancy J. Fischbein, Quynh-Thu Le, Billy W. Loo, Peter G. Maxim

Publikováno v: Head & Neck. 33:103-111

Background Limited data evaluate intensity-modulated radiotherapy (IMRT) for cancers of the hypopharynx and larynx. We report clinical outcomes and failure patterns for these patients. Methods Between September 2001 and December 2007, 42 patients wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::028972ce78971f9833ca6035fadb9936
https://doi.org/10.1002/hed.21406

A Phase II Study of Concurrent Chemoradiation with Weekly Docetaxel, Carboplatin, and Radiation Therapy Followed by Consolidation Chemotherapy with Docetaxel and Carboplatin for Locally Advanced Inoperable Non-small Cell Lung Cancer (NSCLC)

Autor: Anshu K. Jain, Alan B. Sandler, Afshin Dowlati, Jean Wu, Randall S. Hughes, Hak Choy, Larry Schlabach, Nancy J. Muldowney, Lee S. Schwartzberg, Tracy Dobbs

Publikováno v: Journal of Thoracic Oncology. 4:722-727

Introduction The current standard of care for good performance status patients with locally advanced non-small cell lung carcinoma is concurrent chemoradiation, although a clearly superior regimen has not been identified. Docetaxel has been shown to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff82d6d56f81b9539c83846b0cbb32a
https://doi.org/10.1097/jto.0b013e3181a5275c