Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Ansha Qian"'
Autor:
Nestor F. Gonzalez-Cadavid, Ansha Qian, Dolores Vernet, Thomas R. Magee, Gaby Nolazco, Jacob Rajfer
Publikováno v:
The Journal of Sexual Medicine. 3:84-95
Objective Tadalafil, a long‐acting phosphodiesterase type 5 (PDE5) inhibitor, improves the erectile response by inhibiting cyclic guanosine monophosphate (cGMP) breakdown. Sustained higher levels of cGMP may hypothetically upregulate PDE5 expressio
Autor:
Dolores Vernet, Eliane G. Valente, Nestor F. Gonzalez-Cadavid, Jacob Rajfer, Ansha Qian, Monica G. Ferrini
Publikováno v:
Nitric Oxide. 9:229-244
Inducible nitric oxide synthase (iNOS) is expressed in both the fibrotic plaque of Peyronie's disease (PD) in the human, and in the PD-like plaque elicited by injection of TGFbeta1 into the penile tunica albuginea (TA) of the rat. Long-term inhibitio
Autor:
Ansha Qian, Laurence A. Levine, Jacob Rajfer, Fred C. Sander, Thomas R. Magee, Nestor F. Gonzalez-Cadavid
Publikováno v:
Urology. 59:451-457
Objectives. To provide molecular insight into the pathophysiology of Peyronie’s disease (PD), a preliminary profile of differential gene expression between the PD plaque and control tunica albuginea was obtained with DNA microarrays. Methods. Seven
Publikováno v:
Cellular Signalling. 10:101-105
In order to probe the nature of oxytocin receptor (OTR)/G alpha(q/11) protein coupling, we examined the effect of co-expression of OTR intracellular domains on oxytocin-stimulated phosphoinositide turnover in COSM6 cells overexpressing OTR and G alph
Publikováno v:
Endocrinology. 136:1509-1515
Oxytocin stimulates phosphoinositide turnover in myometrium. To elucidate whether the coupling mechanism involves the interaction of oxytocin receptor with GTP-binding proteins, we examined oxytocin stimulation of guanosine triphosphatase (GTPase) ac
Autor:
Robert Gelfand, Nestor F. Gonzalez-Cadavid, Dolores Vernet, Jacob Rajfer, Ansha Qian, Monica G. Ferrini, Thomas R. Magee, Liliana Cantini
Publikováno v:
The journal of sexual medicine. 5(7)
Introduction The primary histologic finding in many urologic disorders, including Peyronie's disease (PD), is fibrosis, mainly mediated by the transforming growth factor β1 (TGFβ1). Aim To determine whether another member of the TGFβ family, myost
Autor:
Dolores, Vernet, Gaby, Nolazco, Liliana, Cantini, Thomas R, Magee, Ansha, Qian, Jacob, Rajfer, Nestor F, Gonzalez-Cadavid
Publikováno v:
Biology of reproduction. 73(6)
Tissue ossification in Peyronie disease (commonly known as Peyronie's disease [PD]), a localized fibrotic lesion within the tunica albuginea (TA) of the penis, may result from osteogenic differentiation of fibroblasts, myofibroblasts, and/or adult st
Publikováno v:
Urology. 64(2)
Objectives To compare the gene expression alterations in human Peyronie's disease (PD) and Dupuytren's disease (DD) to determine whether they share a common pathophysiology. Multiple mRNA expression profiles of human PD have previously shown that gen
Autor:
Thomas R. Magee, Ansha Qian, Monica G. Ferrini, A. Shahed, Dolores Vernet, Jacob Rajfer, Nestor F. Gonzalez-Cadavid
Publikováno v:
Nitric oxide : biology and chemistry. 6(3)
Long-term treatment in rats with l-NAME, an isoform-non-specific inhibitor of nitric oxide synthase (NOS), leads to fibrosis of the heart and kidney, suggesting that nitric oxide (NO) may play a role in preventing tissue fibrosis. In this process, a
Autor:
Ansha Qian, Monica G. Ferrini, Dolores Vernet, Nestor F. Gonzalez-Cadavid, Thomas R. Magee, Jacob Rajfer
Publikováno v:
International journal of impotence research. 14(5)
Currently, surgical intervention is the only efficacious treatment for Peyronie's disease (PD), a fibromatosis of the tunica albuginea of the penis. Therapies based on the molecular pathways for this disease could provide alternatives to surgical tre