Výsledky vyhledávání - "Ansgar Lukowsky"

Deficiency of IL-22 Contributes to a Chronic Inflammatory Disease: Pathogenetic Mechanisms in Acne Inversa

Autor: Robert Sabat, Ansgar Lukowsky, Katrin Witte, Ellen Witte, Annette Buss, Hans Joachim Roewert, Wolfram Sterry, Stefanie Kunz, Kerstin Wolk, Katarzyna Warszawska, Sylke Schneider-Burrus, Markus Krause, Hans-Dieter Volk, Conny Hoeflich

Publikováno v: The Journal of Immunology. 186:1228-1239

Overexpression of the T cell cytokine IL-22 is linked to the development of some chronic diseases, but little is known about IL-22 deficiency in humans. As demonstrated in this study, acne inversa (AI; also designated as Hidradenitis suppurativa) les

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6e3d9d70263fc31533371033ef6454e
https://doi.org/10.4049/jimmunol.0903907

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Prevalence of genetically defined tumor cells in CD7 as well as CD26 positive and negative circulating T-cell subsets in Sézary syndrome

Autor: Wolfram Sterry, Matthias Steinhoff, Chalid Assaf, Ansgar Lukowsky, Sebastian Schöpp, Marc Beyer, Marcus Muche

Publikováno v: Leukemia Research. 33:88-99

For diagnosis and monitoring of Sézary syndrome flow cytometric quantification of CD7- and CD26- T-cells is widely used. Because antigen loss is a characteristic but not disease-specific finding we investigated the significance of this approach. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64a48df88e3d928bf29aa5ede20b1aa2
https://doi.org/10.1016/j.leukres.2008.06.025

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Impact of Molecular Staging Methods in Primary Melanoma: Reverse-Transcriptase Polymerase Chain Reaction (RT-PCR) of Ultrasound-Guided Aspirate of the Sentinel Node Does Not Improve Diagnostic Accuracy, But RT-PCR of Peripheral Blood Does Predict Survival

Autor: Joachim Röwert-Huber, Markus Schwürzer-Voit, Gregor Schäfer-Hesterberg, Martina Kron, Ansgar Lukowsky, Alexander M.M. Eggermont, Juergen Rademaker, A. Schoengen, Markus Krause, Wolfram Sterry, Alexander C.J. van Akkooi, Christiane Voit

Publikováno v: Journal of Clinical Oncology, 26(35), 5742-5747. American Society of Clinical Oncology

Purpose This study analyzes (1) the value of tyrosinase reverse-transcriptase polymerase chain reaction (RT-PCR) of aspirates obtained by ultrasound-guided fine-needle aspiration cytology (US-FNAC) of sentinel nodes (SNs) in patients with melanoma be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe52a1d306743e9b650a31ec6ce71912
https://doi.org/10.1200/jco.2007.13.7653

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Differential Expression of TRAF1 Aids in the Distinction of Cutaneous CD30-Positive Lymphoproliferations

Autor: Horst Dürkop, Florian Wagner, Maria Grünbaum, Wolfram Sterry, Harald Stein, Chalid Assaf, Burkhard Hirsch, Sylke Gellrich, Lothar Lucka, Ansgar Lukowsky

Publikováno v: Journal of Investigative Dermatology. 127(8):1898-1904

Lymphomatoid papulosis (LyP), primary cutaneous anaplastic large T-cell lymphoma (cALCL), and cutaneous infiltrates of systemic anaplastic large cell lymphoma (sALCL) are CD30-positive lymphoproliferative disorders of the skin that overlap clinically

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Absence of Microsatellite Instability and Lack of Evidence for Subclone Diversification in the Pathogenesis and Progression of Mycosis Fungoides

Autor: José A.A. Sanchez, Peter Walden, Tanja C Fischer, Ansgar Lukowsky, Wolfram Sterry, Chalid Assaf, Pierluigi Amerio, Konrad Kölble

Publikováno v: Journal of Investigative Dermatology. 127:1752-1761

Mutator phenotypes with microsatellite instability (MSI) correlated with defects in the mismatch repair system are characteristic for a subset of solid neoplasms, but are rare in non-Hodgkin lymphomas. In mismatch repair-deficient mice, however, muta

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https://doi.org/10.1038/sj.jid.5700793

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Ultrasound-guided Fine Needle Aspiration Cytology prior to Sentinel Lymph Node Biopsy in Melanoma Patients

Autor: Jürgen Rademaker, Gregor Schäfer, Helmut Winter, A Schoengen, Markus Schwürzer-Voit, Martina Kron, Heike Audring, Ansgar Lukowsky, Christiane Voit, Wolfram Sterry

Publikováno v: Annals of Surgical Oncology. 13:1682-1689

Sentinel lymph node biopsy (SLNB) allows early detection of metastases, thereby enabling early treatment in melanoma patients likely to benefit from adjuvant therapies. This prospective study analyzes the possible benefits of additional ultrasound (U

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b7ebe02640edc7668738b48cf2342dd
https://doi.org/10.1245/s10434-006-9046-4

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Monoclonal T-Cell Dyscrasia of Undetermined Significance Associated With Recalcitrant Erythroderma

Autor: Ansgar Lukowsky, Robert Gniadecki

Publikováno v: Scopus-Elsevier

Background: Erythroderma is a diffuse, inflammatory skin reaction that, in rare instances, is associated with hematologic maligancies such as cutaneous T-cell lym- phoma (erythrodermic mycosis fungoides) or T-cell leu- kemia (Sezary syndrome or adult

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::421cf4fd83caaf95c6949fbde4840e24
https://doi.org/10.1001/archderm.141.3.361

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Anti-tumor immune responses and tumor regression induced with mimotopes of a tumor-associated T cell epitope

Autor: Heike Audring, Thomas Linnemann, Karl-Heinz Wiesmüller, Sylke Gellrich, Peter Walden, Sherev Tumenjargal, Ansgar Lukowsky, Wolfram Sterry, J. Marcus Muche

Publikováno v: European Journal of Immunology. 33:3175-3185

Mimotopes provide an alternative to natural T cell epitopes for cancer immune therapy, as they can recruit and stimulate T cell repertoires that deviate from the repertoires engaged with the tumor and exposed to disease-related immune suppression. He

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https://doi.org/10.1002/eji.200324244

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T Cell Receptor-γ Gene Analysis of CD30+ Large Atypical Individual Cells in CD30+ Large Primary Cutaneous T Cell Lymphomas

Autor: Martin Wernicke, Ansgar Lukowsky, Astrid Müller, Sylke Gellrich, Tanja C. Fischer, Heike Audring, Kim Christian Jasch, Anke Wilks, Wolfram Sterry, J. Marcus Muche

Publikováno v: Journal of Investigative Dermatology. 120(4):670-675

The hallmark of primary cutaneous CD30 + large T cell lymphoma are large lymphoid tumor cells, at least 75% of which, by definition, must be positive for CD30. The relatively benign clinical course of this lymphoma type has been explained with CD30-i

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T-cell receptor gene rearrangement analysis of sequential biopsies in cutaneous T-cell lymphomas with the Biomed-2 PCR reveals transient T-cell clones in addition to the tumor clone

Autor: Wolfram Sterry, Ahmed Haider, Staffan Vandersee, Maria Elka Gierisch, Marc Beyer, Chalid Assaf, Daniel Humme, Markus Möbs, Ansgar Lukowsky

Publikováno v: Experimental dermatology. 23(7)

Detection of a dominant T-cell clone by T-cell receptor (TCR) gene rearrangement analysis is often essential for the diagnosis of cutaneous T-cell lymphomas (CTCL). The occurrence of T-cell clones in addition to the diagnostic T-cell clone during the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a57dd9195a22a176d85484b50751dc48
https://pubmed.ncbi.nlm.nih.gov/24862432

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