Molecular mechanisms of isocitrate dehydrogenase 1 (IDH1) mutations identified in tumors: The role of size and hydrophobicity at residue 132 on catalytic efficiency.

Autor: Avellaneda Matteo D; From the Department of Chemistry and Biochemistry, San Diego State University, San Diego, California 92182 and., Grunseth AJ; From the Department of Chemistry and Biochemistry, San Diego State University, San Diego, California 92182 and., Gonzalez ER; From the Department of Chemistry and Biochemistry, San Diego State University, San Diego, California 92182 and., Anselmo SL; From the Department of Chemistry and Biochemistry, San Diego State University, San Diego, California 92182 and., Kennedy MA; From the Department of Chemistry and Biochemistry, San Diego State University, San Diego, California 92182 and., Moman P; From the Department of Chemistry and Biochemistry, San Diego State University, San Diego, California 92182 and., Scott DA; the Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037., Hoang A; From the Department of Chemistry and Biochemistry, San Diego State University, San Diego, California 92182 and., Sohl CD; From the Department of Chemistry and Biochemistry, San Diego State University, San Diego, California 92182 and csohl@mail.sdsu.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2017 May 12; Vol. 292 (19), pp. 7971-7983. Date of Electronic Publication: 2017 Mar 22.