Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Ans E. M. F. Soffers"'
Autor:
Ivonne M.C.M. Rietjens, Ans Punt, Bożena Tyrakowska, Ans E. M. F. Soffers, Suzanne J. P. L. van den Berg
Publikováno v:
Toxicology Research, 4, 23-35
Toxicology Research 4 (2015)
Toxicology Research 4 (2015)
Absorption, distribution, metabolism and excretion (ADME) of food-borne toxic compounds may be influenced by other compounds or constituents present in the food. The present review presents an overview of evidence currently available on food matrix-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::494d528283f5b7d63014366034dd22aa
https://doi.org/10.1039/c4tx00081a
https://doi.org/10.1039/c4tx00081a
Autor:
Amer J. Al-Malahmeh, Ala′ A.A. Al-Subeihi, Abdelmajeed Al-Ajlouni, Reiko Kiwamoto, Jacques Vervoort, Sebastiaan Wesseling, Ivonne M.C.M. Rietjens, Ans E. M. F. Soffers
Publikováno v:
Archives of Toxicology, 91
Archives of Toxicology
Archives of Toxicology 91 (2017)
Archives of Toxicology
Archives of Toxicology 91 (2017)
The present study describes physiologically based kinetic (PBK) models for the alkenylbenzene myristicin that were developed by extension of the PBK models for the structurally related alkenylbenzene safrole in rat and human. The newly developed myri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5770643cbc6fd7419d73a8ca6be8538
https://research.wur.nl/en/publications/physiologically-based-kinetic-modeling-of-the-bioactivation-of-my
https://research.wur.nl/en/publications/physiologically-based-kinetic-modeling-of-the-bioactivation-of-my
Autor:
Ivonne M.C.M. Rietjens, Albertinka J. Murk, Ans E. M. F. Soffers, Hein E Falke, Wiratno, David Hernández-Moreno
Publikováno v:
Food and Chemical Toxicology 56 (2013)
Food and Chemical Toxicology, 56, 483-490
Food and Chemical Toxicology, 56, 483-490
This study presents a consumer and farmer safety evaluation on the use of four botanical pesticides in pepper berry crop protection. The pesticides evaluated include preparations from clove, tuba root, sweet flag and pyrethrum. Their safety evaluatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4c00eb080427f9c84550984aac0dadb
https://doi.org/10.1016/j.fct.2013.01.033
https://doi.org/10.1016/j.fct.2013.01.033
Autor:
Jan van Benthem, Jan Willem van der Laan, Ruud Woutersen, Ans E. M. F. Soffers, E. Dinant Kroese, Mirjam Luijten, Cyrille Krul
Publikováno v:
Regulatory Toxicology and Pharmacology, 81, 242-249
Regulatory Toxicology and Pharmacology 81 (2016)
Regulatory Toxicology and Pharmacology 81 (2016)
Sub-chronic toxicity studies of 163 non-genotoxic chemicals were evaluated in order to predict the tumour outcome of 24-month rat carcinogenicity studies obtained from the EFSA and ToxRef databases. Hundred eleven of the 148 chemicals that did not in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5959c690d17e8ee32116523922a6bb2
https://research.wur.nl/en/publications/prediction-of-carcinogenic-potential-of-chemicals-using-repeated-
https://research.wur.nl/en/publications/prediction-of-carcinogenic-potential-of-chemicals-using-repeated-
Autor:
Reiko Kiwamoto, Amer J. Al_Malahmeh, Jacques Vervoort, Sebastiaan Wesseling, Ivonne M.C.M. Rietjens, Abdalmajeed M. Alajlouni, Ala′ A.A. Al-Subeihi, Ans E. M. F. Soffers
Publikováno v:
Food and Chemical Toxicology 89 (2016)
Food and Chemical Toxicology, 89, 138-150
Food and Chemical Toxicology, 89, 138-150
The present study developed physiologically-based kinetic (PBK) models for the alkenylbenzene apiol in order to facilitate risk assessment based on read-across from the related alkenylbenzene safrole. Model predictions indicate that in rat liver the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25dcb7e065021f8dcabbaa8c94e3d23a
https://research.wur.nl/en/publications/mode-of-action-based-risk-assessment-of-the-botanical-food-borne-
https://research.wur.nl/en/publications/mode-of-action-based-risk-assessment-of-the-botanical-food-borne-
Autor:
Jacques Vervoort, Bert Spenkelink, Ivonne M.C.M. Rietjens, Ans E. M. F. Soffers, Ans Punt, Suzanne J. P. L. van den Berg, Stephen Ngeleja
Publikováno v:
Chemical Research in Toxicology 25 (2012) 11
Chemical Research in Toxicology
Chemical Research in Toxicology, 25(11), 2352-2367
Chemical Research in Toxicology
Chemical Research in Toxicology, 25(11), 2352-2367
The present study describes physiologically based kinetic (PBK) models for the alkenylbenzene elemicin (3,4,5-trimethoxyallylbenzene) in rat and human, based on the PBK models previously developed for the structurally related alkenylbenzenes estragol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5069133251069e9fdc5b6b3b0ab683b
https://doi.org/10.1021/tx300239z
https://doi.org/10.1021/tx300239z
Autor:
Jacques Vervoort, Albertinka J. Murk, Ivonne M.C.M. Rietjens, Tamas Griff, Tingting Du, Elton Zvinavashe, Hans H. J. van den Berg, Ans E. M. F. Soffers
Publikováno v:
Chemosphere, 75(11), 1531-1538
Chemosphere 75 (2009) 11
Chemosphere 75 (2009) 11
Within the REACH regulatory framework in the EU, quantitative structure-activity relationships (QSAR) models are expected to help reduce the number of animals used for experimental testing. The objective of this study was to develop QSAR models to de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fd16cb9098b916252c2f65d17ae16df
https://doi.org/10.1016/j.chemosphere.2009.01.081
https://doi.org/10.1016/j.chemosphere.2009.01.081
Publikováno v:
Chemical Research in Toxicology, 11, 503-512
Chemical Research in Toxicology 11 (1998)
Chemical Research in Toxicology 11 (1998)
The in vivo cytochrome P450-catalyzed aromatic hydroxylation of a series of fluorobenzenes was investigated with special emphasis on the importance of the fluorine NIH shift. The results obtained demonstrate a minor role for the NIH shift in the meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6514a630cade36558c5ed018df5739b4
https://doi.org/10.1021/tx980053i
https://doi.org/10.1021/tx980053i
Autor:
Ivonne M.C.M. Rietjens, Jacques Vervoort, Ans E. M. F. Soffers, Martine M. C. Velraeds, Janneke Koerts
Publikováno v:
Chemical Research in Toxicology. 10:279-288
In a previous study, the in vivo cytochrome P450-catalyzed regioselectivity of aromatic ring hydroxylation for a series of (poly)fluorobenzenes could be quantitatively predicted by the calculated frontier orbital density distribution in the aromatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad674a50330a14ad8859def7318d1a0
https://doi.org/10.1021/tx960048j
https://doi.org/10.1021/tx960048j
Autor:
M.J.H. van Haandel, Ivonne M.C.M. Rietjens, P.K. Patel, Ans E. M. F. Soffers, Cees Veeger, M.S. Mondal, J.J.M. Vervoort, Digambar V. Behere, Sandeep Modi
Publikováno v:
Scopus-Elsevier
The second-order rate constants for the oxidation of a series of phenol derivatives by horseradish peroxidase compound II were compared to computer-calculated chemical parameters characteristic for this reaction step. The phenol derivatives studied w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad3aea47a84034a0a0c4300f02a9ee98
https://doi.org/10.1007/s007750050079
https://doi.org/10.1007/s007750050079