Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Ans De Beuckelaer"'
Autor:
Muriel Smet, Monique Willart, Jan-Ake Gustafsson, Ans De Beuckelaer, Johan Grooten, Thomas Naessens, Karl Vergote, Seppe Vander Beken, Lien Van Hoecke, Knut R. Steffensen, Bart N. Lambrecht
Publikováno v:
Immunity, Inflammation and Disease. 4:350-361
Introduction Liver X receptors (LXRs) are nuclear receptors that function as cholesterol sensors and regulate cholesterol homeostasis. High cholesterol has been recognized as a risk factor in asthma; however, the mechanism of this linkage is not know
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c13538b72cb7fa021f244f43c734c2e8
https://doi.org/10.1002/iid3.118
https://doi.org/10.1002/iid3.118
Autor:
Bruno G. De Geest, Lorenzo Albertazzi, Hui Li, Thomas De Beer, Riet De Rycke, Nane Vanparijs, Stefaan De Koker, Ans De Beuckelaer, Kaat Fierens, Katleen Van Steendam, Dieter Deforce, Johan Grooten, Zhiyue Zhang, Bart N. Lambrecht, Martijn J. Schuijs, Natàlia Feiner Gracia
Publikováno v:
ACS Applied Materials & Interfaces, 8(2), 1147-1155. American Chemical Society
Nanomaterials hold potential of altering the interaction between therapeutic molecules and target cells or tissues. High aspect ratio nanomaterials in particular have been reported to possess unprecedented properties and are intensively investigated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::898af06ee4c748d9213135a98c425953
https://doi.org/10.1021/acsami.5b08963
https://doi.org/10.1021/acsami.5b08963
Autor:
Bart N. Lambrecht, Ans De Beuckelaer, Kim Deswarte, Yupeng Li, Bruno G. De Geest, Euna Yoo, Sunil A. David, Stefan Lienenklaus, Nikunj M. Shukla, Michael J. H. Brush, Kathryn L. Trautman, Alex C. D. Salyer
Publikováno v:
Bioconjugate chemistry. 29(8)
Immunogens carried in lymphatic fluid drain via afferent vessels into regional lymph nodes and facilitate the efficient induction of appropriate immune responses. The lymphatic system possesses receptors recognizing hyaluronic acid (HA). Covalent con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93d212b72d216be726f1eb49f50950d0
https://pubmed.ncbi.nlm.nih.gov/29969553
https://pubmed.ncbi.nlm.nih.gov/29969553
Publikováno v:
Trends in molecular medicine. 23(3)
mRNA vaccines have emerged as potent tools to elicit antitumor T cell immunity. They are characterized by a strong induction of type I interferons (IFNs), potent inflammatory cytokines affecting T cell differentiation and survival. Recent reports hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::245b946599092f2ea704bdf6bbbd2e80
https://pubmed.ncbi.nlm.nih.gov/28185789
https://pubmed.ncbi.nlm.nih.gov/28185789
Autor:
Stefaan De Koker, Lien Lybaert, Kim Deswarte, Nane Vanparijs, Lutz Nuhn, Bruno G. De Geest, Nikunj M. Shukla, Stefan Lienenklaus, Bart N. Lambrecht, Alex C. D. Salyer, G. Verstraete, Johan Grooten, Ans De Beuckelaer, Sunil A. David
Agonists of Toll-like receptors (TLRs) are potent activators of the innate immune system and hold promise as vaccine adjuvant and for anticancer immunotherapy. Unfortunately, in soluble form they readily enter systemic circulation and cause systemic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe5d58237f9f90ed0bcfafb86a72ba0e
https://hdl.handle.net/10033/618490
https://hdl.handle.net/10033/618490
Autor:
Bernard Ucakar, Niek N. Sanders, Kevin Vanvarenberg, Laure Lambricht, Ans De Beuckelaer, Véronique Préat, Stefan Lienenklaus, Johan Grooten, Lien Van Hoecke, Gaëlle Vandermeulen, Pascale Lipnik
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 24(9)
DNA vaccination holds great promise for the prevention and treatment of cancer and infectious diseases. However, the clinical ability of DNA vaccines is still controversial due to the limited immune response initially observed in humans. We hypothesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1269a8e54c6158b4be2c1feddc67523
https://pubmed.ncbi.nlm.nih.gov/27434590
https://pubmed.ncbi.nlm.nih.gov/27434590
Autor:
Niek N. Sanders, Johan Grooten, Charlotte Pollard, Siegfried Weiss, Guido Vanham, Ans De Beuckelaer, Kenny Roose, Xavier Saelens, Thomas Naessens, Lien Van Hoecke, Muriel Smet, Stefan Lienenklaus, Sandra Van Lint, Vimal Kumar Udhayakumar, Stefaan De Koker
Publikováno v:
Molecular therapy
Given their high potential to evoke cytolytic T cell responses, tumor antigen-encoding messenger RNA (mRNA) vaccines are now being intensively explored as therapeutic cancer vaccines. mRNA vaccines clearly benefit from wrapping the mRNA into nano-siz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb3d292ef0d1091394ea3f68a829b0e
https://pubmed.ncbi.nlm.nih.gov/27506450
https://pubmed.ncbi.nlm.nih.gov/27506450
Autor:
Philip J. Santangelo, Cian M. McCrudden, Kim Deswarte, Ans De Beuckelaer, Kenny Roose, Jonathan L. Kirschman, Bruno G. De Geest, Joanne McCaffrey, Stefan Lienenklaus, Helen O. McCarthy, Lien Van Hoecke, Vimal Kumar Udhayakumar, Daryll Vanover, Stefaan De Koker, Johan Grooten
Publikováno v:
Advanced Healthcare Materials
To date, the mRNA delivery field has been heavily dominated by lipid-based systems. Reports on the use of nonlipid carriers for mRNA delivery in contrast are rare in the context of mRNA vaccination. This paper describes the potential of a cell-penetr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea853516dc92e75106efa7fca4cc8c1a
https://doi.org/10.1002/adhm.201601412
https://doi.org/10.1002/adhm.201601412
Autor:
Johan Grooten, Alain Vanderplasschen, Véronique Préat, Gaëlle Vandermeulen, Kevin Vanvarenberg, Laure Lambricht, Ans De Beuckelaer, Catherine Uyttenhove, Anca Reschner, Stefaan De Koker
Publikováno v:
Vaccine. 33(28)
We investigated the influence of the site of administration of DNA vaccine on the induced immune response. DNA vaccines were administered by electroporation at three different sites: tibial cranial muscle, abdominal skin and ear pinna. Aiming to draw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aa849aa54fde3a92b8079bea416771c
https://pubmed.ncbi.nlm.nih.gov/25980430
https://pubmed.ncbi.nlm.nih.gov/25980430
Autor:
Bart N. Lambrecht, Xavier Saelens, Ans De Beuckelaer, Bert Schepens, Monique Willart, Lien Van Hoecke, Johan Grooten, Stefaan De Koker, Charlotte Pollard, Muriel Smet, Thomas Naessens
Publikováno v:
The Journal of allergy and clinical immunology. 137(3)
Background Human respiratory syncytial virus (RSV) is a frequent cause of asthma exacerbations, yet the susceptibility of asthmatic patients to RSV is poorly understood. Objective We sought to address the contribution of resident alveolar macrophages
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d2f933b8b52342480a8b999e347f29
https://pubmed.ncbi.nlm.nih.gov/26560044
https://pubmed.ncbi.nlm.nih.gov/26560044