Výsledky vyhledávání - "Anouk Van Nuffel"

Akademický článek

HIV Triggers a cGAS-Dependent, Vpu- and Vpr-Regulated Type I Interferon Response in CD4+ T Cells

Autor: Jolien Vermeire, Ferdinand Roesch, Daniel Sauter, Réjane Rua, Dominik Hotter, Anouk Van Nuffel, Hanne Vanderstraeten, Evelien Naessens, Veronica Iannucci, Alessia Landi, Wojciech Witkowski, Ann Baeyens, Frank Kirchhoff, Bruno Verhasselt

Publikováno v: Cell Reports, Vol 17, Iss 2, Pp 413-424 (2016)

Several pattern-recognition receptors sense HIV-1 replication products and induce type I interferon (IFN-I) production under specific experimental conditions. However, it is thought that viral sensing and IFN induction are virtually absent in the mai

Externí odkaz: https://doaj.org/article/28681999f7c64ed3858dee947ca2ac9f

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Akademický článek

Virion encapsidated HIV-1 Vpr induces NFAT to prime non-activated T cells for productive infection

Autor: Kristin Höhne, Ramona Businger, Anouk van Nuffel, Sebastian Bolduan, Herwig Koppensteiner, Ann Baeyens, Jolien Vermeire, Eva Malatinkova, Bruno Verhasselt, Michael Schindler

Publikováno v: Open Biology, Vol 6, Iss 7 (2016)

The majority of T cells encountered by HIV-1 are non-activated and do not readily allow productive infection. HIV-1 Vpr is highly abundant in progeny virions, and induces signalling and HIV-1 LTR transcription. We hence hypothesized that Vpr might be

Externí odkaz: https://doaj.org/article/df062d398dec47ddad6f4958223fd15a

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Akademický článek

Quantification of reverse transcriptase activity by real-time PCR as a fast and accurate method for titration of HIV, lenti- and retroviral vectors.

Autor: Jolien Vermeire, Evelien Naessens, Hanne Vanderstraeten, Alessia Landi, Veronica Iannucci, Anouk Van Nuffel, Tom Taghon, Massimo Pizzato, Bruno Verhasselt

Publikováno v: PLoS ONE, Vol 7, Iss 12, p e50859 (2012)

Quantification of retroviruses in cell culture supernatants and other biological preparations is required in a diverse spectrum of laboratories and applications. Methods based on antigen detection, such as p24 for HIV, or on genome detection are viru

Externí odkaz: https://doaj.org/article/bf70130907834298a42cbc81ef5420e4

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HIV Triggers a cGAS-Dependent, Vpu- and Vpr-Regulated Type I Interferon Response in CD4+ T Cells

Autor: Daniel Sauter, Anouk Van Nuffel, Bruno Verhasselt, Ann Baeyens, Alessia Landi, Evelien Naessens, Ferdinand Roesch, Wojciech Witkowski, Dominik Hotter, Hanne Vanderstraeten, Veronica Iannucci, Frank Kirchhoff, Jolien Vermeire, Réjane Rua

Publikováno v: Cell Reports, Vol 17, Iss 2, Pp 413-424 (2016)
CELL REPORTS

SummarySeveral pattern-recognition receptors sense HIV-1 replication products and induce type I interferon (IFN-I) production under specific experimental conditions. However, it is thought that viral sensing and IFN induction are virtually absent in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32b965cab1227951254591fbd7aff7ad
http://www.sciencedirect.com/science/article/pii/S2211124716312451

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HIV-1 Vpr N-terminal tagging affects alternative splicing of the viral genome

Autor: Karin Weening, Linos Vandekerckhove, Evelien Naessens, Kris Gevaert, Sven Eyckerman, Eva Claeys, Wim Trypsteen, Bruno Verhasselt, Ann Baeyens, Anne-Marie Reilly, Anouk Van Nuffel

Publikováno v: SCIENTIFIC REPORTS
Scientific Reports

To facilitate studies on Vpr function in replicating HIV-1, we aimed to tag the protein in an infectious virus. First we showed that N-, but not C-terminal HA/FLAG tagging of Vpr protein preserves Vpr cytopathicity. Cloning the tags into proviral DNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa43781064350f285728484a9d7d71ac
https://biblio.ugent.be/publication/8159575/file/8159588

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One Protein to Rule them All: Modulation of Cell Surface Receptors and Molecules by HIV Nef

Autor: Veronica Iannucci, Anouk Van Nuffel, Pieter Meuwissen, Alessia Landi, Bruno Verhasselt

Publikováno v: Current HIV Research; Vol 9
Current HIV Research
Ghent University Academic Bibliography
CURRENT HIV RESEARCH

The HIV-1, HIV-2 and SIV Nef protein are known to modulate the expression of several cell surface receptors and molecules to escape the immune system, to alter T cell activation, to enhance viral replication, infectivity and transmission and overall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d3460369811c15650b5729d2f63ba3

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Replication competent virus as an important source of bias in HIV latency models utilizing single round viral constructs

Autor: Ward De Spiegelaere, Pawel Bonczkowski, Cory H. White, Laura J. Martins, Linos Vandekerckhove, Christopher H. Woelk, Vicente Planelles, Jolien Vermeire, Wojciech Witkowski, Maja Kiselinova, Alberto Bosque, Wim Trypsteen, Eva Malatinkova, Anouk Van Nuffel, Bruno Verhasselt

Publikováno v: RETROVIROLOGY
Retrovirology

The central memory T cell (TCM) model forms a unique HIV-1 latency model based on primary cells that closely resemble in vivo TCM. The virus employed in this model is based on an engineered vector incapable of replication after initial infection. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30b42431b881798cd0371e02b9aec5d0
https://hdl.handle.net/1854/LU-5704738

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Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms

Autor: Anouk Van Nuffel, Tom Taghon, Bruno Verhasselt, Inge Van de Walle, Evelien Naessens, Kevin K. Ariën, Veronique Stove, Kati Pulkkinen, Oliver T. Fackler, Jan Schmökel, Eduardo O’Neill, J. Victor Garcia, Kathleen Van Landeghem, Kalle Saksela, Hanne Vanderstraeten, Frank Kirchhoff, Michael Schindler

Publikováno v: Retrovirology
RETROVIROLOGY

Background A nef gene is present in all primate lentiviral genomes and is important for high viral loads and progression to AIDS in human or experimental macaque hosts of HIV or SIV, respectively. In these hosts, infection of the thymus results in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::579b25db1ae34cc11d3337c90755a06a
http://hdl.handle.net/10138/162613

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Quantification of Reverse Transcriptase Activity by Real-Time PCR as a Fast and Accurate Method for Titration of HIV, Lenti- and Retroviral Vectors

Autor: Massimo Pizzato, Veronica Iannucci, Evelien Naessens, Tom Taghon, Alessia Landi, Bruno Verhasselt, Hanne Vanderstraeten, Anouk Van Nuffel, Jolien Vermeire

Publikováno v: PLoS ONE
PLoS ONE, Vol 7, Iss 12, p e50859 (2012)
PLOS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9037a7d2d67ab05fc0b464c382887510
http://europepmc.org/articles/PMC3515444

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Vpr content of HIV-1 virions determines infection of resting peripheral blood CD4+ lymphocytes

Autor: Elien Vandermarliere, Kathleen Moens, Hanne Vanderstraeten, Sophie Vermaut, Stijn Vanhee, Petra Van Damme, Ann Baeyens, Wojciech Witkowski, Bruno Verhasselt, Francis Impens, Anouk Van Nuffel, Kathleen Vanlandeghem, Evelien Naessens, Kris Gevaert

Publikováno v: Retrovirology
RETROVIROLOGY

Background The HIV-1 Vpr protein is a 14 kDa accessory protein, required for efficient replication in macrophages. Vpr is incorporated into HIV virions, believed to participate in the docking of the HIV-1 pre-integration complex to the nucleus and to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b52f6b7e4fd48751d4f1525454973d20
http://europepmc.org/articles/PMC3848172

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