Cadherin-13 is a critical regulator of GABAergic modulation in human stem-cell-derived neuronal networks

Autor: Teun M. Klein Gunnewiek, Maria Rosaria Vitale, Brooke L. Latour, Sophie Jansen, Nael Nadif Kasri, Jon-Ruben van Rhijn, Dirk Schubert, Eline J.H. van Hugte, Martijn Selten, Jitske Bak, Anouk H.A. Verboven, Alessia Anania, Ilse M. van der Werf, Katrin Linda, Klaus-Peter Lesch, Johanna E. M. Zöller, Hans van Bokhoven, Chantal Schoenmaker, Moritz Negwer, Britt Mossink, Monica Frega, Jason M. Keller, Shan Wang, Astrid R. Oudakker

Publikováno v: Molecular Psychiatry, 27, 1-18
Molecular Psychiatry, 27, 1-18. Nature Publishing Group
Mol Psychiatry
Molecular Psychiatry, 27, 1, pp. 1-18
Molecular Psychiatry, 27(1), 1-18. Nature Publishing Group

Activity in the healthy brain relies on a concerted interplay of excitation (E) and inhibition (I) via balanced synaptic communication between glutamatergic and GABAergic neurons. A growing number of studies imply that disruption of this E/I balance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bcf03da1f0e21468baa3ed5c5d714df
https://hdl.handle.net/2066/248849

Imbalanced autophagy causes synaptic deficits in a human model for neurodevelopmental disorders

Autor: Marina P Hommersom, Chantal Schoenmaker, Astrid R. Oudakker, Katrin Linda, Lynn Devilee, Elly Lewerissa, Nael Nadif Kasri, Anouk H.A. Verboven, Bert B.A. de Vries, Michele Gabriele, Giuseppe Testa, David A. Koolen, Hans van Bokhoven, Monica Frega, Teun M. Klein Gunnewiek, Edda Ulferts, Dirk Schubert

Publikováno v: Autophagy, 18, 2, pp. 423-442
Autophagy, 18(2), 423-442. Landes Bioscience
Autophagy, 18, 423-442

Contains fulltext : 248864.pdf (Publisher’s version ) (Open Access) Macroautophagy (hereafter referred to as autophagy) is a finely tuned process of programmed degradation and recycling of proteins and cellular components, which is crucial in neuro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eef0853aed0d4bd89a0459755da98920
https://repository.ubn.ru.nl/handle/2066/248864

Sonlicromanol improves neuronal network dysfunction and transcriptome changes linked to m.3243A>G heteroplasmy in iPSC-derived neurons

Autor: Teun M. Klein Gunnewiek, Jan A.M. Smeitink, Chantal Schoenmaker, Herma Renkema, Bert B.A. de Vries, Nael Nadif Kasri, Julien Beyrath, Iris Pelgrim, Peter-Bram A.C. ’t Hoen, Anouk H.A. Verboven, Tamas Kozicz, Mark Hogeweg

Publikováno v: Stem Cell Reports, 16, 9, pp. 2197-2212
ISSCR
Stem Cell Reports, 16, 2197-2212
Stem Cell Reports

Summary Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) is often caused by an adenine to guanine variant at m.3243 (m.3243A>G) of the MT-TL1 gene. To understand how this pathogenic variant affects the nervous system

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8c47ff44bd8a9bf01c1436acfdc0986
https://repository.ubn.ru.nl/handle/2066/237505

KANSL1 Deficiency Causes Neuronal Dysfunction by Oxidative Stress-Induced Autophagy

Autor: Lynn Devilee, Giuseppe Testa, Dirk Schubert, EIly I. Lewerissa, Nael Nadif Kasri, Monica Frega, Edda Ulferts, Michele Gabriele, Hans van Bokhoven, Katrin Linda, Chantal Schoenmaker, Teun M. Klein Gunnewiek, Anouk H.A. Verboven, Bert B.A. de Vries, David A. Koolen, Astrid R. Oudakker

Autophagy is a finely tuned process of programmed degradation and recycling of proteins and cellular components, which is crucial in neuronal function and synaptic integrity. Mounting evidence implicates chromatin remodelling in fine-tuning autophagy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f45fdd8d57d13640905758701b93e5c9
https://doi.org/10.1101/2020.08.07.241257

Contributors

Autor: Ryan Abbott, Ahmed T. Ahmed, Martin Alda, Ananda B. Amstadter, Ole A. Andreassen, Victoria K. Arnet, Cedric Bardy, Csaba Barta, Bernhard T. Baune, Elisabeth R.B. Becker, Bettina H. Bewernick, Joanna M. Biernacka, Stefan Bleich, Marissa S. Blumenthal, Cristian Bonvicini, Chad A. Bousman, Lisa C. Brown, Christie L. Burton, Han Cao, Joanne S. Carpenter, Danielle Cath, Micah Cearns, Donald D. Chang, Alexander Charney, Christopher R.K. Ching, Kate M. Chitty, Liliana G. Ciobanu, Scott R. Clark, A.M. Cole, Jane L. Collinson, Lucía Colodro-Conde, A. Corvin, David R. Cotter, Shane P.M. Cross, Jacob J. Crouse, John F Cryan, Darina Czamara, Shareefa Dalvie, Franziska Degenhardt, Douglas L. Delahanty, Timothy G Dinan, Valsamma Eapen, Harris A. Eyre, Andreas J. Forstner, Helge Frieling, Mark A. Frye, Lillian J. Gehue, Daniel Geller, Nicholas Glozier, Beata R. Godlewska, Andrea N. Goldstein-Piekarski, Ilona Gorbovskaya, Hans Jörgen Grabe, Iria Grande, Paul Grant, Zarina Greenberg, Edna Grünblatt, Adam J. Guastella, Anand Gururajan, Tim Hahn, Alisha S.M. Hall, Blake A. Hamilton, Alfons O. Hamm, Catherine J. Harmer, Jessica Hartmann, Michael A. Hauser, Daniel F. Hermens, Ian B. Hickie, Frank Iorfino, Neda Jahanshad, Iris E. Jansen, Angela G. Junglen, Helmet T. Karim, Manreena Kaur, Nastassja Koen, Dagmar Koethe, Jim Lagopoulos, Rico S.Z. Lee, Sophie E. Legge, Douglas F. Levinson, F. Markus Leweke, Julio Licinio, David E.J. Linden, Jonathan C.W. Liu, Anita Lo, Falk W. Lohoff, Adriana Lori, Ulrike Lueken, Carlo Maj, Patrick D. McGorry, Roger S. McIntyre, Agnes B. McMahon, Divya Mehta, Cristina Mei, Rajendra A. Morey, Daniel J. Müller, Sharon L. Naismith, Barnaby Nelson, Alexandra Neyazi, Alissa Nichles, Caroline M. Nievergelt, Nicole R. Nugent, C. Ormond, Antonio F. Pardiñas, Seth W. Perry, Claudia Pisanu, Danielle Posthuma, Renee-Marie Ragguett, Cyrus Raji, Margarita Raygada, Owen M. Rennert, Charles F. Reynolds, Sophie Sabherwal, Estela Salagre, Pamela H. Saunders, Catia Scassellati, Thomas E. Schlaepfer, Lianne Schmaal, Klaus Oliver Schubert, Emanuel Schwarz, Elizabeth M. Scott, Jan Scott, Jonathan Sebat, Giovanni Severino, Christina Sheerin, Ajeet B. Singh, Balwinder Singh, Stephen F. Smagula, Olav B. Smeland, Alicia K. Smith, Jill L. Sorcher, Rachael Spooner, Alessio Squassina, Eli A. Stahl, Dan J. Stein, Fabian Streit, Patrick F. Sullivan, Jennifer A. Sumner, Paul M. Thompson, Ashleigh M. Tickell, Catherine Toben, Monica Uddin, Arshya Vahabzadeh, Linh K. Van, Margot P. van de Weijer, Odile A. van den Heuvel, Sandra Van der Auwera, Anouk H.A. Verboven, Eduard Vieta, Zoe Wainer, James T.R. Walters, Hunna J. Watson, Django White, Leanne M. Williams, Stephanie H. Witt, Yin Yao, Zeynep Yilmaz, Gwyneth Zai, Natalia Zmicerevska

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::514eb9380e87992f5fb7588eaacecc89
https://doi.org/10.1016/b978-0-12-813176-3.09992-2