Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Anouar Hafiane"'
Publikováno v:
Lipids in Health and Disease, Vol 21, Iss 1, Pp 1-10 (2022)
Abstract Background Calcification of the aortic valve is a common heart valve disorder, in some cases leading to clinically impactful severe aortic stenosis (AS). Sex-specific differences in aortic valve calcification (ACV) exist, with women having a
Externí odkaz:
https://doaj.org/article/0d976988551443b7b28c8236bd70d777
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Externí odkaz:
https://doaj.org/article/d68762785a154e04838ee7b10834c294
Autor:
Anouar Hafiane, MSc, PhD, Alessandro Pisaturo, MSc, Annalisa Ronca, Matteo Incerti, PhD, Robert S. Kiss, PhD, Elda Favari, PhD
Publikováno v:
BBA Advances, Vol 1, Iss , Pp 100003- (2021)
Objective: Probucol is a cholesterol-lowering agent whose ability to prevent atherosclerosis is currently under study. Herein, we investigate the putative mechanism of probucol by observation of changes in cellular cholesterol efflux and lipid drople
Externí odkaz:
https://doaj.org/article/a130ee3ca1b94334aad0d0cdcba56a5c
Autor:
Bin Yu, PhD, Anouar Hafiane, PhD, George Thanassoulis, MD, Leah Ott, BS, Nial Filwood, MD, Marta Cerruti, PhD, Ophélie Gourgas, MS, Dominique Shum-Tim, MD, Hamood Al Kindi, MD, Benoit de Varennes, MD, Alawi Alsheikh-Ali, MD, PhD, Jacques Genest, MD, Adel Schwertani, DM, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 2, Iss 4, Pp 358-371 (2017)
Lipoprotein(a), or Lp(a), significantly increased alkaline phosphatase activity, release of phosphate, calcium deposition, hydroxyapatite, cell apoptosis, matrix vesicle formation, and phosphorylation of signal transduction proteins; increased expres
Externí odkaz:
https://doaj.org/article/b14075748f2349b1b7679c98085a3718
Autor:
Anouar Hafiane
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 6, Iss 3, p 26 (2019)
Plaque development and rupture are hallmarks of atherosclerotic vascular disease. Despite current therapeutic developments, there is an unmet necessity in the prevention of atherosclerotic vascular disease. It remains a challenge to determine at an e
Externí odkaz:
https://doaj.org/article/adf50ed9b8d54563b2babeb7da089785
Autor:
Iulia Iatan, Dana Bailey, Isabelle Ruel, Anouar Hafiane, Steven Campbell, Larbi Krimbou, Jacques Genest
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 11, Pp 2043-2055 (2011)
Recent studies have identified an ABCA1-dependent, phosphatidylcholine-rich microdomain, called the “high-capacity binding site” (HCBS), that binds apoA-I and plays a pivotal role in apoA-I lipidation. Here, using sucrose gradient fractionation,
Externí odkaz:
https://doaj.org/article/5dbaa5ec3f174966bf7e76de938b6c6d
Autor:
Paul M.M. Weers, Arti B. Patel, Leon C-P. Wan, Emmanuel Guigard, Cyril M. Kay, Anouar Hafiane, Ruth McPherson, Yves L. Marcel, Robert S. Kiss
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 1, Pp 35-44 (2011)
We have identified a novel mutation in apoA-I (serine 36 to alanine; S36A) in a human subject with severe hypoalphalipoproteinemia. The mutation is located in the N-terminal region of the protein, which has been implicated in several functions, inclu
Externí odkaz:
https://doaj.org/article/44ab4a210c6547b9836718c49b5fd09d
Autor:
Dana Bailey, Isabelle Ruel, Anouar Hafiane, Haley Cochrane, Iulia Iatan, Matti Jauhiainen, Christian Ehnholm, Larbi Krimbou, Jacques Genest
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 4, Pp 785-797 (2010)
The specifics of nascent HDL remodeling within the plasma compartment remain poorly understood. We developed an in vitro assay to monitor the lipid transfer between model nascent HDL (LpA-I) and plasma lipoproteins. Incubation of α-125I-LpA-I with p
Externí odkaz:
https://doaj.org/article/678f2e7782d646f78abdaef28dd86e7a
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0131997 (2015)
Apolipoprotein (apo) mimetic peptides replicate some aspects of HDL function. We have previously reported the effects of compound ATI-5261 on its ability to replicate many functions of native apo A-I in the process of HDL biogenesis. ATI-5261 induced
Externí odkaz:
https://doaj.org/article/80cbe5e6e367472abe0295fa1983b439
Autor:
Karina, Gasbarrino, Anouar, Hafiane, Ioanna, Gianopoulos, Huaien, Zheng, Christos S, Mantzoros, Stella S, Daskalopoulou
Publikováno v:
Metabolism. 140:155381
Cholesterol efflux capacity (CEC) as a measure of high-density lipoprotein functionality is independently and inversely associated with increased risk of cardiovascular events and mortality, and advanced plaque morphology. Adipokines, adipose tissue-