Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Anooshirvan Shayeganpour"'
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31ea9a6540dc461eb6ffc542e6fb099c
https://doi.org/10.2139/ssrn.4172934
https://doi.org/10.2139/ssrn.4172934
Autor:
Anooshirvan Shayeganpour, Sergei I. Ochkur, John D. Kim, Nutan Srivastava, Lian Willetts, Miguel C. Seabra, Redwan Moqbel, Rudolf Hamburg, Paige Lacy, James J. Lee
Publikováno v:
Journal of Leukocyte Biology. 94:1265-1274
Eosinophil degranulation has been implicated in inflammatory processes associated with allergic asthma. Rab27a, a Rab-related GTPase, is a regulatory intracellular signaling molecule expressed in human eosinophils. We postulated that Rab27a regulates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8e9bd6e9e856f285a804bed1b6b6712
https://doi.org/10.1189/jlb.0812431
https://doi.org/10.1189/jlb.0812431
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 81:142-148
Co-administration of P-glycoprotein (P-gp) inhibitors such as cyclosporine A (CyA) and its analogue valspodar with doxorubicin (DOX) can result in diminished clearance of DOX, leading to accentuated toxicity. The purpose of this study was to evaluate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d8dd6dd409a3e179153540f0c8a1a68
https://doi.org/10.1016/j.ejpb.2012.02.003
https://doi.org/10.1016/j.ejpb.2012.02.003
Autor:
Yunfang Zhang, Anooshirvan Shayeganpour, John M. Seubert, Darryl C. Zeldin, Julie F. Foley, Taibeh Orujy Jukar, Page Myers, Abraham Nyska, J. Alyce Bradbury, Ketul R Chaudhary, Joan P. Graves, Douglas C. Rouse, Sri N. Batchu, Haitham El-Sikhry, Laura M. DeGraff
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 297:H37-H46
Human cytochrome P-450 (CYP)2J2 is abundant in heart and active in biosynthesis of epoxyeicosatrienoic acids (EETs). Recently, we demonstrated that these eicosanoid products protect myocardium from ischemia-reperfusion injury. The present study utili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6d5f8efa3f2cd780c99d7b0bd5b0d11
https://doi.org/10.1152/ajpheart.00983.2008
https://doi.org/10.1152/ajpheart.00983.2008
Publikováno v:
Journal of Pharmacy and Pharmacology. 60:1625-1632
To model the impact of intestinal components associated with a high fat meal on metabolism of amiodarone, rat everted intestinal sacs were evaluated for their ability to metabolize the drug to its active metabolite (desethylamiodarone) under a variet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::beae4b1bd5fc30d512a18e7b8bb30bce
https://doi.org/10.1211/jpp.60.12.0008
https://doi.org/10.1211/jpp.60.12.0008
Publikováno v:
Biopharmaceutics & Drug Disposition. 29:159-166
The pharmacokinetics of desethylamiodarone (DEA), the active metabolite of amiodarone (AM), were studied in the rat after administration of AM or preformed metabolite. Rats received 10 mg/kg of either intravenous or oral AM HCl or DEA base. Blood sam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47256dfb128082182411f45305ad1d25
https://doi.org/10.1002/bdd.599
https://doi.org/10.1002/bdd.599
Publikováno v:
Pharmaceutical Research. 24:672-678
To study the effect of hyperlipoproteinemia on in vitro distribution of amiodarone (AM) and its prevalent metabolite desethylamiodarone (DEA) in human and rat plasma. Human and rat normolipidemic (NL) and hyperlipidemic (HL) plasma were spiked with A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9502ffffd26b5889f40ea71a4d50360
https://doi.org/10.1007/s11095-006-9186-z
https://doi.org/10.1007/s11095-006-9186-z
Publikováno v:
Biomedical Chromatography. 21:546-552
A simple, rapid and reliable high-performance liquid chromatographic (HPLC) method was developed and validated for the determination of curcumin in rat plasma. Plasma was precipitated with acetonitrile after addition of the internal standard (IS), 4-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b4376b53adeccabcb3734b1f4d3955f
https://doi.org/10.1002/bmc.795
https://doi.org/10.1002/bmc.795
Autor:
Michael Logan, S.O. Odemuyiwa, Ramses Ilarraza, Anooshirvan Shayeganpour, Francis Davoine, Redwan Moqbel, Paige Lacy, Darryl J. Adamko, Carina Majaesic, Yingqi Wu
Degranulation from eosinophils in response to secretagogue stimulation is a regulated process that involves exocytosis of granule proteins through specific signalling pathways. One potential pathway is dependent on cyclin-dependent kinase 5 (Cdk5) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b685deaba05c0f74a4bb9e3146efb1f
https://europepmc.org/articles/PMC4368170/
https://europepmc.org/articles/PMC4368170/
Publikováno v:
Chirality. 19:22-33
The pharmacokinetics of the antimalarial drug (+/-)-halofantrine are stereoselective in humans and rats. To better understand the stereoselective metabolism of the drug to its primary metabolite, desbutylhalofantrine (DHF), a series of in vitro and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b528b7aadddccb659e26a7b89fc64b3
https://doi.org/10.1002/chir.20334
https://doi.org/10.1002/chir.20334